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4 results for “delayed benefits”
Clinical Benefit of Rigourous AV Delay Optimization in Patients With a Dual Chamber Pacemaker
ClinicalTrials.gov study NCT01998256. IPD Sharing: Not stated. Countries: 1. Publications: 19.
Data from: Delayed dispersal and the costs and benefits of different routes to independent breeding in a cooperatively breeding bird
Why sexually mature individuals stay in groups as nonreproductive subordinates is central to the evolution of sociality and cooperative breeding. To understand such delayed dispersal, its costs and benefits need to be compared with those of permanently leaving to float through the population. However, comprehensive comparisons, especially regarding differences in future breeding opportunities, are rare. Moreover, extraterritorial prospecting by philopatric individuals has generally been ignored, even though the factors underlying this route to independent breeding may differ from those of strict philopatry or floating. We use a comprehensive predictive framework to explore how various costs, benefits and intrinsic, environmental and social factors explain philopatry, prospecting, and floating in Seychelles warblers (Acrocephalus sechellensis). Not only floaters more likely obtained an independent breeding position before the next season than strictly philopatric individuals, but also suffered higher mortality. Prospecting yielded similar benefits to floating but lower mortality costs, suggesting that it is overall more beneficial than floating and strict philopatry. While prospecting is probably individual-driven, although limited by resource availability, floating likely results from eviction by unrelated breeders. Such differences in proximate and ultimate factors underlying each route to independent breeding highlight the need for simultaneous consideration when studying the evolution of delayed dispersal.
Clinical benefits of sex steroids given as a priming prior to GH provocative test or as a growth-promoting therapy in peripubertal growth delays: Results of a retrospective study among ENDO-ERN centres
<p>Objectives: Sex steroids, administered as a priming before GH stimulation tests<br> (GHST) to differentiate between growth hormone deficiency (GHD) and constitutional<br> delay of growth and puberty (CDGP) or as growth-promoting therapy using<br> low-dose sex steroids (LDSS) in CDGP, are much debated. We aimed to compare auxological<br> outcomes of CDGP or GHD children undergoing primed or unprimed GHST<br> and to evaluate LDSS treatment in CDGP.<br> Design: Retrospective study among three paediatric University Hospitals in Italy and<br> UK.<br> Methods: 184 children (72 females) aged 12.4 ± 2.08 years underwent primed (/P+)<br> or unprimed (/P−) GHST and were followed up until final height (FH). CDGP patients<br> were untreated (CDG P−) or received LDSS (CDGP+). The cohort included 34 CDG<br> P−/P+, 12 CDGP+/P+, 51 GHD/P+, 29 CDG P−/P−, 2 CDGP+/P− and 56 GHD/P−. FH<br> standard deviation score (SDS), Δ SDS FH-target height (TH) and degree of success<br> (−1 ≤ Δ SDS FH-SDS TH ≤ +1) were outcomes of interest.<br> Results: GHD/P+ had better FH-SDS (−0.87 vs −1.49; P = .023) and ΔSDS FH-TH<br> (−0.35 vs −0.77; P = .002) than CDGP−/P+. Overall, GHD/P+ showed the highest degree<br> of success (90%, P = .006). Regardless of priming, both rhGH and LDSS improved<br> degree of success compared to no treatment (89% and 86% vs 63%, P = .0009).<br> GHD/P+ showed a trend towards a higher proportion of permanent GHD compared<br> to GHD/P- (30.43% vs 15.09%; P = .067).<br> Conclusion: In peripubertal children, priming before GHST improves diagnostic accuracy<br> of GHST for idiopathic GHD. LDSS treatment improves auxological outcomes<br> in CDGP</p>
Data from: Delayed dispersal and the costs and benefits of different routes to independent breeding in a cooperatively breeding bird
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