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ShareScore release 0.9.0
Dataset results
18 results for “developmental robustness”
Developmental timing of Drosophila pachea pupae is robust to temperature changes
<p>Rearing temperature is correlated with the timing and speed of development in a wide range of poikiloterm animals that do not regulate their body temperature. However, exceptions exist, especially in species that live in environments with high temperature extremes or oscillations. <em>Drosophila pachea</em> is endemic to the Sonoran desert in Mexico, in which temperatures and temperature variations are extreme. We wondered if the developmental timing in <em>D. pachea</em> may be sensitive to differing rearing temperatures or if it remains constant. We determined the overall timing of the <em>Drosophila pachea</em> life-cycle at different temperatures. The duration of pupal development was similar at 25 °C, 29 °C and 32 °C, although the relative progress differed at particular stages. Thus, <em>D. pachea</em> may have evolved mechanisms to buffer temperature effects on developmental speed, potentially to ensure proper development and individual's fitness in desert climate conditions.</p>
Drosophila suzukii wing spot size is robust to developmental temperature
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Developmental timing of Drosophila pachea pupae is robust to temperature changes
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Data from: The impact of gene expression variation on robustness and evolvability of a developmental gene regulatory network
Regulatory interactions buffer development against genetic and environmental perturbations, but adaptation requires phenotypes to change. We investigated the relationship between robustness and evolvability within the gene regulatory network underlying development of the larval skeleton in the sea urchin Strongylocentrotus purpuratus. We find extensive variation in gene expression in this network throughout development in a natural population, some of which has a heritable genetic basis. Switch-like regulatory interactions predominate during early development, buffer expression variation, and may promote the accumulation of cryptic genetic variation affecting early stages. Regulatory interactions during later development are typically more sensitive (linear), allowing variation in expression to affect downstream target genes. Variation in skeletal morphology is associated primarily with expression variation of a few, primarily structural, genes at terminal positions within the network. These results indicate that the position and properties of gene interactions within a network can have important evolutionary consequences independent of their immediate regulatory role.
Data from: The impact of gene expression variation on robustness and evolvability of a developmental gene regulatory network
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Data from: Making a queen: an epigenetic analysis of the robustness of the honey bee (Apis mellifera) queen developmental pathway
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Data from: Coordination of wing and whole body development at developmental milestones ensures robustness against environmental and physiological perturbations
Development produces correctly patterned tissues under a wide range of conditions that alter the rate of development in the whole body. We propose two hypotheses through which tissue patterning could be coordinated with whole body development to generate this robustness. Our first hypothesis states that tissue patterning is tightly coordinated with whole body development over time. The second hypothesis is that tissue patterning aligns at developmental milestones. To distinguish between our two hypotheses, we developed a staging scheme for the wing imaginal discs of Drosophila larvae using the expression of canonical patterning genes, linking our scheme to three whole body developmental events, moulting, larval wandering and pupariation. We used our scheme to explore how the progression of pattern changes when developmental time is altered either by changing temperature or by altering the timing of hormone synthesis that drives developmental progression. We found the expression pattern in the wing disc always aligned at moulting and pupariation, indicating that these key developmental events represent milestones. Between these milestones, the progression of pattern showed greater variability in response to changes in temperature and alterations in physiology. Furthermore, our data showed that discs from wandering larvae had greater variability in their patterning stage. Thus, for wing disc patterning wandering does not appear to be a developmental milestone. Our findings reveal that tissue patterning remains robust against environmental and physiological perturbations by aligning at developmental milestones. Furthermore, our work provides an important glimpse into how the development of individual tissues is coordinated with the body as a whole.
Data from: Coordination of wing and whole body development at developmental milestones ensures robustness against environmental and physiological perturbations
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Developmentally regulated Shh expression is robust to TAD perturbations
GEO Series GSE135840. Mus musculus. 23 samples. Type: Other.
Drosophila Modulo is Essential for Transposon Silencing and Developmental Robustness.
GEO Series GSE240478. Drosophila melanogaster. 31 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Prerequisite Barcoding of Cell-Type-Restricted Enhancers by ESC Transcription Factors in ESCs Licenses Their Robust Developmental Activation
GEO Series GSE81681. Mus musculus. 26 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other; Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Thyroid progenitors are robustly derived from embryonic stem cells through transient, developmental stage-specific overexpression of Nkx2-1
GEO Series GSE92572. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Prerequisite Barcoding of Cell-Type-Restricted Enhancers by ESC Transcription Factors in ESCs Licenses Their Robust Developmental Activation [4C-Seq]
GEO Series GSE81678. Mus musculus. 4 samples. Type: Other.
Prerequisite Barcoding of Cell-Type-Rpecific Enhancers by ESC Transcription Factors in ESCs Licenses Their Robust Developmental Activation [RNA-seq]
GEO Series GSE96903. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
Prerequisite Barcoding of Cell-Type-Restricted Enhancers by ESC Transcription Factors in ESCs Licenses Their Robust Developmental Activation [Pro-cap]
GEO Series GSE81677. Mus musculus. 2 samples. Type: Other.
Prerequisite Barcoding of Cell-Type-Restricted Enhancers by ESC Transcription Factors in ESCs Licenses Their Robust Developmental Activation [ATAC-Seq]
GEO Series GSE81679. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Prerequisite Barcoding of Cell-Type-Restricted Enhancers by ESC Transcription Factors in ESCs Licenses Their Robust Developmental Activation [ChIP-Seq]
GEO Series GSE81676. Mus musculus. 9 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Prerequisite Barcoding of Cell-Type-Restricted Enhancers by ESC Transcription Factors in ESCs Licenses Their Robust Developmental Activation [MeDIP-Seq]
GEO Series GSE81680. Mus musculus. 2 samples. Type: Methylation profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.