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39 results for “developmental toxicity”
CompTox Zebrafish developmental toxicity processed data
<p>Please cite the published paper and original data source.</p> <p>A classification data set for 19 endpoints of Zebrafish developmental toxicity for QSAR modelling.</p> <p>The original data was downloaded from <a href="https://comptox.epa.gov/dashboard">https://comptox.epa.gov/dashboard</a></p> <p>See also references below.</p> <ul> <li>20201230_tx_zf.csv -- Endpoint data</li> <li>20201230_tx_zf_smiles.txt -- SMILES of the structures</li> <li>20201230_tx_zf_descriptors_rdkit.csv -- Descriptors</li> <li>20201230_tx_zf_fp_r3_v5120.csv -- Fingerprints</li> </ul>
Systematic Scoping Literature Review of Embryonic Stem Cells In Vitro Developmental Toxicity Tests: Included publications library
<p>The publications included in the systematic scoping review conducted according to the protocol:<a href="https://zenodo.org/record/2528920">https://zenodo.org/record/2528920</a></p> <p> </p>
An advancement in developmental and reproductive toxicity (DART) risk assessment: evaluation of a bioactivity and exposure-based NAM toolbox
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Data from: Automated morphological feature assessment for zebrafish embryo developmental toxicity screens
Detection of developmental phenotypes in zebrafish embryos typically involves a visual assessment and scoring of morphological features by an individual researcher. Subjective scoring could impact results and be of particular concern when phenotypic effect patterns are also used as a diagnostic tool to classify compounds. Here we introduce a quantitative morphometric approach based on image analysis of zebrafish embryos. A software called FishInspector was developed to detect morphological features from images collected using an automated system to position zebrafish embryos. The analysis was verified and compared with visual assessments of three participating laboratories using three known developmental toxicants (methotrexate, dexamethasone and topiramate) and two negative compounds (loratadine and glibenclamide). The quantitative approach exhibited higher sensitivity and made it possible to compare patterns of effects with the potential to establish a grouping and classification of developmental toxicants. Our approach improves the robustness of phenotype scoring and reliability of assay performance and, hence, is anticipated to improve the predictivity of developmental toxicity screening using the zebrafish embryo.
Figure 1 in Toxicity of spiromesifen on different developmental stages of two-spotted spider mite, Tetranychus urticae Koch (Acari: Tetranychidae)
Figure 1. The effectiveness (%) of spiromesifen on different stages of Tetranychus urticae – A. Eggs hatching ratio (2011); B. Eggs hatching ratio (2012); C. Immature stages (2011); D. Immature stages (2012); E. Adult (females,
Data from: Automated morphological feature assessment for zebrafish embryo developmental toxicity screens
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Role of AHR in cardiac developmental toxicity of PAHs
GEO Series GSE57946. Danio rerio. 109 samples. Type: Expression profiling by array.
Developmental toxicity of tire wear particle (TWP) leachates produced in the presence or absence of simulated natural light
GEO Series GSE233518. Danio rerio. 16 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic responses to Deepwater Horizon oil in mahi-mahi (Coryphaena hippurus) embryos reveals time and oil-dependent linkages between molecular initiating events and developmental toxicity
GEO Series GSE79675. Coryphaena hippurus. 32 samples. Type: Expression profiling by high throughput sequencing.
Toxicogenomic signatures associated with methylmercury induced developmental toxicity in the zebrafish embryos.
GEO Series GSE206531. Danio rerio. 12 samples. Type: Expression profiling by high throughput sequencing.
Assessment of unique behavioral, morphological, and molecular alterations in the comparative developmental toxicity profiles of PFHxA using the zebrafish model system
GEO Series GSE211171. Danio rerio. 16 samples. Type: Expression profiling by array.
Exploring maternal and developmental toxicity of perfluoroalkyl ether acids PFO4DA and PFO5DoA using hepatic transcriptomics and serum metabolomics
GEO Series GSE266378. Rattus norvegicus. 111 samples. Type: Expression profiling by high throughput sequencing.
Developmental toxicity of Nafion byproduct 2 (NBP2) in the Sprague-Dawley rat
GEO Series GSE192589. Rattus norvegicus. 90 samples. Type: Expression profiling by high throughput sequencing.
DNA Damage Response Is Involved in the Developmental Toxicity of Mebendazole in Zebrafish Retina
GEO Series GSE75245. Danio rerio. 24 samples. Type: Expression profiling by array.
Developmental toxicity of the fungicide Boscalid and primary metabolite M510F01 in zebrafish embryos
GEO Series GSE232317. Danio rerio. 14 samples. Type: Expression profiling by high throughput sequencing.
Assessment of unique behavioral, morphological, and molecular alterations in the comparative developmental toxicity profiles of PFOA using the zebrafish model system
GEO Series GSE211169. Danio rerio. 16 samples. Type: Expression profiling by array.
Lurasidone Induces Developmental Toxicity and Behavioral Impairments in Zebrafish Embryos
GEO Series GSE299985. Danio rerio. 6 samples. Type: Expression profiling by high throughput sequencing.
Elucidating The Role Of ∆9-Tetrahydrocannabinol (Thc) And Cannabidiol (Cbd) In Developmental Toxicity
GEO Series GSE164128. Danio rerio. 24 samples. Type: Expression profiling by high throughput sequencing.
Analysis of MicroRNA Expression in Embryonic Developmental Toxicity Induced by microcystin arginine arginine (MC-RR).
GEO Series GSE29329. Danio rerio. 8 samples. Type: Non-coding RNA profiling by array.
Epigenetic and Developmental Effects of In Utero Exposure to Environmental Toxicants
ClinicalTrials.gov study NCT01815385. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.