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ShareScore release 0.9.0
Dataset results
94 results for “diastolic dysfunction”
Noninvasive Neuromodulation to Reserve Diastolic Dysfunction
ClinicalTrials.gov study NCT02983448. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Improving Metabolic Health in Patients With Diastolic Dysfunction
ClinicalTrials.gov study NCT03448185. IPD Sharing: NO. Countries: 1. Publications: 1.
The Effects of Systolic Blood Pressure Lowering on Diastolic Function Using Valsartan + Amlodipine in Patients With Hypertension and Diastolic Dysfunction
ClinicalTrials.gov study NCT00523549. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Ubiquitin Ligase Wwp1 Gene Deletion Attenuates Diastolic Dysfunction in Pressure Overload Hypertrophy
<p><strong><em>Background.</em></strong> Heart failure with a preserved left ventricular (LV) ejection fraction (HFpEF) often arises from a prolonged LV pressure overload (LVPO) and accompanied by abnormal extracellular matrix (ECM) accumulation. The E3 ubiquitin ligase WWP1 is a fundamental determinant ECM turnover. We tested the hypothesis that genetic ablation of<em> Wwp1</em> would alter the progression of LVPO induced HFpEF.</p> <p><strong><em>Methods/Results</em></strong><em>.</em> LV echocardiography in mice with global <em>Wwp1</em> deletion (n=41; <em>Wwp1<sup>-/-</sup></em>) was performed at 12 weeks of age (Baseline) and then at 2 and 4 weeks following LVPO (transverse aortic banding) or surgery without LVPO induction. Age-matched wild type mice (<em>Wwp1<sup>+/+</sup></em>; n=33) underwent identical protocols. LV EF remained constant and unchanged with LVPO and LV mass increased in both groups but was lower in the <em>Wwp1<sup>-/-</sup></em> mice. With LVPO, the E/A ratio, an index of LV filling, was 3.97 + 0.46 in <em>Wwp1<sup>+/+</sup></em> but was 1.73 + 0.19 in the <em>Wwp1<sup>-/-</sup></em> group (p<0.05). At the transcriptional level, mRNA for fibrillar collagens (types I and III) decreased by approximately 50% in <em>Wwp1<sup>-/-</sup></em> compared to the <em>Wwp1<sup>+/+</sup></em> group at 4 weeks post-LVPO (p<0.05) and was paralleled by a similar difference in LV fibrillar collagen content as measured by histochemistry. Moreover, mRNA levels for determinants favoring ECM accumulation, such as transforming growth factor (TGF) increased with LVPO, but were lower in the <em>Wwp1<sup>-/-</sup></em> group.</p> <p><strong><em>Summary.</em></strong> The absence of <em>Wwp1</em> reduced the development of LVH and subsequent progression to HFpEF. Modulating the WWP1 pathway could be a therapeutic target to alter the natural history of HFpEF.</p>
Effects of Remifentanil on Cardiac Function in Patients With Diastolic Dysfunction
ClinicalTrials.gov study NCT04117009. IPD Sharing: NO. Countries: 1. Publications: 2.
Diastolic dYsfunctioN AssessMent in critICally Ill Patients
ClinicalTrials.gov study NCT04584203. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
SIDAMI - Sildenafil and Diastolic Dysfunction After Acute Myocardial Infarction (AMI)
ClinicalTrials.gov study NCT01046838. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Diastolic Dysfunction in Morbidly Obese Patients Undergo Bariatric Surgery
ClinicalTrials.gov study NCT04128735. IPD Sharing: NO. Countries: 1. Publications: 3.
Exercise Study on Cardiac Function in Patients With Diabetes Mellitus Type 2 and Diastolic Dysfunction
ClinicalTrials.gov study NCT01206725. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Personalized Pacing: A New Paradigm for Patients With Diastolic Dysfunction or Heart Failure With Preserved Ejection Fraction
ClinicalTrials.gov study NCT04721314. IPD Sharing: NO. Countries: 1. Publications: 2.
Characterizing HIV-related Diastolic Dysfunction
ClinicalTrials.gov study NCT02860156. IPD Sharing: NO. Countries: 1. Publications: 1.
Effect of Diastolic Dysfunction on Dynamic Cardiac Monitors
ClinicalTrials.gov study NCT04177225. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Diastolic Dysfunction 2025
ClinicalTrials.gov study NCT07190846. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Simvastatin and Diastolic Dysfunction
ClinicalTrials.gov study NCT01061450. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Screening of Diastolic Dysfunction With Impedance Cardiography in Hypertensive Patients
ClinicalTrials.gov study NCT03209141. IPD Sharing: NO. Countries: 1. Publications: 20.
Effect of Liraglutide on Diastolic Dysfunction on Cardiac MRI in Type 2 Diabetes Patients
ClinicalTrials.gov study NCT02655770. IPD Sharing: Not stated. Countries: 1. Publications: 10.
Analysis of Incidence and Risk Factors of Severe Cardiovascular Events in Patients With Diastolic Dysfunction
ClinicalTrials.gov study NCT03138109. IPD Sharing: NO. Countries: 1. Publications: 6.
A Study to Test the Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Left Ventricular Diastolic Dysfunction
ClinicalTrials.gov study NCT01172756. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Aerobic Versus Combined Exercise and Diastolic Dysfunction
ClinicalTrials.gov study NCT04916184. IPD Sharing: NO. Countries: 1. Publications: 3.
Sleep Apnea Diagnosis Using a Novel Pacemaker Algorithm and Link With Aldosterone Plasma Level in Patients Presenting With Diastolic Dysfunction
ClinicalTrials.gov study NCT02751021. IPD Sharing: NO. Countries: 1. Publications: 1.
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OpenNeuro
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