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4 results for “diet soda”
Early-life exposures to diet soda and aspartame are associated with autism in males
<p>Since its introduction, aspartame—the leading sweetener in U.S. diet sodas (DS)—has been reported to cause neurological problems in some users. In prospective studies, the offspring of mothers who consumed diet sodas/beverages (DSB) daily during pregnancy experienced increased health problems. We hypothesized that gestational/early-life exposure to ≥1 DS/day (DS<sub>early</sub>) or equivalent aspartame (ASP<sub>early</sub>: ≥177 mg/day) increases autism risk. The case-control Autism Tooth Fairy Study obtained retrospective dietary recalls for DSB and aspartame consumption during pregnancy/breastfeeding from the mothers of 235 offspring with autism spectrum disorder (ASD: cases) and 121 neurotypically developing offspring (controls). The exposure odds ratios (ORs) for DS<sub>early</sub> and ASP<sub>early</sub> were computed for autism, ASD, and the non-regressive conditions of each. Among males, DS<sub>early</sub> odds were tripled among autism (OR = 3.1; 95% CI: 1.02, 9.7) and non-regressive autism (OR = 3.5; 95% CI: 1.1, 11.1) cases; ASP<sub>early</sub> odds were even higher: OR = 3.4 (95% CI: 1.1, 10.4) and 3.7 (95% CI: 1.2, 11.8), respectively, among autism and non-regressive autism cases (p < 0.05 for each). ORs for non-regressive ASD in males were almost tripled but were not statistically significant: DS<sub>early</sub> OR = 2.7 (95% CI: 0.9, 8.4); ASP<sub>early</sub> OR = 2.9 (95% CI: 0.9, 8.8). No statistically significant associations were found in females. Our findings contribute to the growing literature raising concerns about potential offspring harm from maternal DSB/aspartame intake in pregnancy.</p>
Early-life exposures to diet soda and aspartame are associated with autism in males
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Neurological Impacts of Artificial Sweeteners in the Context of Diet Sodas
ClinicalTrials.gov study NCT04048681. IPD Sharing: NO. Countries: 1. Publications: 0.
Effect of Diet Orange Soda on Urinary Lithogenicity
ClinicalTrials.gov study NCT01330940. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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