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899 results for “diffusion in cells”
Research data supporting "Online quantitative monitoring of live cell engineered cartilage growth using diffuse fiber-optic Raman spectroscopy"
<p>Research data supporting the publication:</p> <p>M. Bergholt, 2017, Online quantitative monitoring of live cell engineered cartilage growth using diffuse fiber-optic Raman spectroscopy, Biomaterials, Volume 140, September 2017, Pages 128–137, DOI: 10.1016/j.biomaterials.2017.06.015</p>
Aquaporins Embedded in a Cell Membrane with O2 Diffusion
<p>This is an illustration of an aquaporin embedded in a cell membrane with O2 diffusion as well. </p>
Text-fig. 10. Platanoxylon cf. haydenii, a, e, h: UF 279-34470; b, c, d, f g: UF 279-34469. a, b: Diffuse porous wood with vessels solitary and in small multiples, which are mostly tangential or oblique, diffuse and diffuse-in-aggregates axial parenchyma., TS. c–e: Scalariform perforation plates. f, g: Opposite intervessel pits, TLS. h: Two size classes of rays, TLS. Platanus sp., UF 279- 24552. i: Predominantly solitary vessels, diffuse and diffuse-in-aggregates parenchyma, growth ring boundary distinct, noded rays, TS. j: Simple perforation plates (PP), RLS. k: Body of ray with procumbent ray cells, RLS. l: Scalariform perforation plate, RLS. m: Rays of two sizes, wide rays>10-seriate, TLS. Scale bars: 200 µm in a, b, h, i, m; 100 µm in j, k: 50 µm in c, d, e, f, l. in A Diverse Assemblage Of Late Eocene Woods From Oregon, Western Usa
Text-fig. 10. Platanoxylon cf. haydenii, a, e, h: UF 279-34470; b, c, d, f g: UF 279-34469. a, b: Diffuse porous wood with vessels solitary and in small multiples, which are mostly tangential or oblique, diffuse and diffuse-in-aggregates axial parenchyma., TS. c–e: Scalariform perforation plates. f, g: Opposite intervessel pits, TLS. h: Two size classes of rays, TLS. Platanus sp., UF 279- 24552. i: Predominantly solitary vessels, diffuse and diffuse-in-aggregates parenchyma, growth ring boundary distinct, noded rays, TS. j: Simple perforation plates (PP), RLS. k: Body of ray with procumbent ray cells, RLS. l: Scalariform perforation plate, RLS. m: Rays of two sizes, wide rays>10-seriate, TLS. Scale bars: 200 µm in a, b, h, i, m; 100 µm in j, k: 50 µm in c, d, e, f, l.
Text-fig. 9. Wataria kvacekii sp. nov., UF 279-24556. a: Wood ring-porous, earlywood with 2–3 rows of wide pores, vessels solitary and in radial multiples of 2, axial parenchyma scanty vasicentric and some apotracheal diffuse-in-aggregates, TS. b: Series of vessel elements with simple perforations, axial parenchyma strands adjacent to vessels, RLS. c: Alternate intervessel pitting, vessel element end walls horizontal, RLS. d: Vessel-axial parenchyma pitting similar to intervessel pitting, RLS. e, f: Rays with tile cells, storied axial parenchyma, some strands chambered crystalliferous, TLS. g: Detail of ray, TLS. h: Storied imperforate elements. Scale bars: 200 µm in a; 100 µm in b, e; 50 µm in c, d, f, h; 20 µm in g. in A Diverse Assemblage Of Late Eocene Woods From Oregon, Western Usa
Text-fig. 9. Wataria kvacekii sp. nov., UF 279-24556. a: Wood ring-porous, earlywood with 2–3 rows of wide pores, vessels solitary and in radial multiples of 2, axial parenchyma scanty vasicentric and some apotracheal diffuse-in-aggregates, TS. b: Series of vessel elements with simple perforations, axial parenchyma strands adjacent to vessels, RLS. c: Alternate intervessel pitting, vessel element end walls horizontal, RLS. d: Vessel-axial parenchyma pitting similar to intervessel pitting, RLS. e, f: Rays with tile cells, storied axial parenchyma, some strands chambered crystalliferous, TLS. g: Detail of ray, TLS. h: Storied imperforate elements. Scale bars: 200 µm in a; 100 µm in b, e; 50 µm in c, d, f, h; 20 µm in g.
Text-fig. 7. Hamamelidoxylon crystalliferum sp. nov., UF 279-34464. a: Diffuse porous wood with exclusively solitary vessels, tending to be angular in outline, TS. b: Growth ring boundary, marked by radially narrowed fibers, latewood vessels narrower than earlywood vessels of the next ring, fibers thick-walled, no axial parenchyma visible, TS. c: Scalariform intervessel pits in narrow vessel (left), fibers with distinctly bordered pits, TLS. d: Scalariform perforation plate, tyloses (T) formation from marginal ray cell, TLS. e: Scalariform perforation plates with fewer than 15 bars (PP), RLS. f: Vessel-ray parenchyma pits with in A Diverse Assemblage Of Late Eocene Woods From Oregon, Western Usa
Text-fig. 7. Hamamelidoxylon crystalliferum sp. nov., UF 279-34464. a: Diffuse porous wood with exclusively solitary vessels, tending to be angular in outline, TS. b: Growth ring boundary, marked by radially narrowed fibers, latewood vessels narrower than earlywood vessels of the next ring, fibers thick-walled, no axial parenchyma visible, TS. c: Scalariform intervessel pits in narrow vessel (left), fibers with distinctly bordered pits, TLS. d: Scalariform perforation plate, tyloses (T) formation from marginal ray cell, TLS. e: Scalariform perforation plates with fewer than 15 bars (PP), RLS. f: Vessel-ray parenchyma pits with
Text-fig. 5. Lithocarpoxylon ashwillii sp. nov., UF 279-24544. a, b: Semi-ring porous wood, exclusively solitary vessels in a radial/ diagonal arrangement, diffuse axial parenchyma, TS. c: Homocellular rays composed of procumbent cells; vasicentric tracheids; vessel elements with simple perforation plates (PP), TLS. d: Vessel-ray parenchyma pits (VRP) with reduced borders, vertical, RLS. e: Crystalliferous axial parenchyma strand (C) with a single crystal per chamber; ray with procumbent cells, RLS. f: Aggregate ray (right) composed of loosely associated 1–2-seriate rays, TLS. g: Uniseriate rays, thin-walled tyloses in vessels, vasicentric tracheids (VT). Lithocarpoxylon sp., UF 279-84864. h, i: Semi-ring porous wood, exclusively solitary vessels in radial arrangement. j: Aggregate ray and uniseriate rays. k: Scalariform perforation plate with fewer than 10 bars. l: Vessel-ray parenchyma pits with reduced borders to simple, vertical. Scale bars: 200 µm in a, b, f, h, j; 100 µm in c, i; 50 µm in d. e; 20 µm in k, l. in A Diverse Assemblage Of Late Eocene Woods From Oregon, Western Usa
Text-fig. 5. Lithocarpoxylon ashwillii sp. nov., UF 279-24544. a, b: Semi-ring porous wood, exclusively solitary vessels in a radial/ diagonal arrangement, diffuse axial parenchyma, TS. c: Homocellular rays composed of procumbent cells; vasicentric tracheids; vessel elements with simple perforation plates (PP), TLS. d: Vessel-ray parenchyma pits (VRP) with reduced borders, vertical, RLS. e: Crystalliferous axial parenchyma strand (C) with a single crystal per chamber; ray with procumbent cells, RLS. f: Aggregate ray (right) composed of loosely associated 1–2-seriate rays, TLS. g: Uniseriate rays, thin-walled tyloses in vessels, vasicentric tracheids (VT). Lithocarpoxylon sp., UF 279-84864. h, i: Semi-ring porous wood, exclusively solitary vessels in radial arrangement. j: Aggregate ray and uniseriate rays. k: Scalariform perforation plate with fewer than 10 bars. l: Vessel-ray parenchyma pits with reduced borders to simple, vertical. Scale bars: 200 µm in a, b, f, h, j; 100 µm in c, i; 50 µm in d. e; 20 µm in k, l.
Text-fig. 3. Cercidiphyllum cf. alalongum R.A.SCOTT et E.A.WHEELER, UF 279-24543. a, b: Diffuse-porous wood, exclusively solitary vessels, axial parenchyma rare, thick-walled fibers, TS. c: Scalariform perforation plate with more than 30 bars, RLS. d: Helical thickenings (HT) in vessel element tip, RLS. e: Opposite to scalariform intervessel pits, RLS. f, g: Heterocellular rays 1–2 cells wide, occasionally uniseriate and biseriate portions of similar width, TLS. h: Ray with alternating rows of procumbent and upright (-square) cells, RLS. Scale bars: 200 µm in a; 100 µm in b, f; 50 µm in c, g, h; 20 µm in d, e. in A Diverse Assemblage Of Late Eocene Woods From Oregon, Western Usa
Text-fig. 3. Cercidiphyllum cf. alalongum R.A.SCOTT et E.A.WHEELER, UF 279-24543. a, b: Diffuse-porous wood, exclusively solitary vessels, axial parenchyma rare, thick-walled fibers, TS. c: Scalariform perforation plate with more than 30 bars, RLS. d: Helical thickenings (HT) in vessel element tip, RLS. e: Opposite to scalariform intervessel pits, RLS. f, g: Heterocellular rays 1–2 cells wide, occasionally uniseriate and biseriate portions of similar width, TLS. h: Ray with alternating rows of procumbent and upright (-square) cells, RLS. Scale bars: 200 µm in a; 100 µm in b, f; 50 µm in c, g, h; 20 µm in d, e.
Text-fig. 16. Photomicrographs of thin sections of specimen BP/16/1734, Terminalioxylon mozambicense sp. nov. from Mhengere Hill, Gorongosa, Mozambique. a: TS with round vessels, scanty paratracheal to vasicentric parenchyma, diffuse and narrow terminal or initial bands; b: TS at higher magnification, note the very narrow rays; c: TLS, vessels with small alternate pits, and partly tylosed; d–g: TLS with crystals (small white arrows) in the parenchyma cells, medium to thick-walled fibres and uniseriate, low rays; h: TLS, rays up to 20 cells high; i: RLS rays with procumbent body cells and 1–2 rows of marginal upright cells. in Stratigraphy, Chronology And Palaeontology Of The Tertiary Rocks Of The Cheringoma Plateau, Mozambique
Text-fig. 16. Photomicrographs of thin sections of specimen BP/16/1734, Terminalioxylon mozambicense sp. nov. from Mhengere Hill, Gorongosa, Mozambique. a: TS with round vessels, scanty paratracheal to vasicentric parenchyma, diffuse and narrow terminal or initial bands; b: TS at higher magnification, note the very narrow rays; c: TLS, vessels with small alternate pits, and partly tylosed; d–g: TLS with crystals (small white arrows) in the parenchyma cells, medium to thick-walled fibres and uniseriate, low rays; h: TLS, rays up to 20 cells high; i: RLS rays with procumbent body cells and 1–2 rows of marginal upright cells.
Lattice Boltzmann simulation of liquid water transport in gas diffusion layers of proton exchange membrane fuel cells: Impact of gas diffusion layer and microporous layer degradation on effective transport properties
<p><span>Underlying data to publication Sarkezi-Selsky et al., <em>J. Pow. Sour.</em> 556 (2023) 232415,<span> https://doi.org/10.1016/j.jpowsour.2022.232415</span> <br><br>Polymer Electrolyte Membrane Fuel Cells (PEMFCs) represent a promising technology for clean drivetrain solutions, in particular for heavy-duty applications. However, lifetime requirements demand high durability of each cell component.<br></span><span>In this work, transport of liquid water through pristine and degraded gas diffusion layers (GDL) was simulated with a 3D Color-Gradient Lattice Boltzmann model. The GDL microstructure was reconstructed </span><span>from high-resolution X-ray micro-computed tomography (</span><span>μ</span><span>-CT) of an impregnated Freudenberg H14. The </span><span>effect of a microporous layer (MPL) was considered by reconstruction of an impregnated and MPL-coated H14. Aged microstructures were generated artificially, assuming loss of polytetrafluoroethylene (PTFE) within the GDL and increase of MPL macroporosity as main degradation mechanisms. Liquid water transport within aged microstructures was simulated by imposing a liquid phase flow rate until breakthrough was reached. Subsequently, the GDL microstructures were analyzed for their breakthrough characteristics by means of saturation and effective gas transport properties. When the MPL was pristine, no distinct GDL degradation effect was observable, this was attributed to the MPL dominating capillary transport. MPL aging, however, led to increased saturations and thus to a deterioration of the effective gas transport. With a partially degraded MPL, aging of the GDL then appeared to affect the breakthrough characteristics.</span></p>
spindle cell variant diffuse large B-cell lymphoma (NGS annotation file; high confidence calls) hematolrep-2136295
<p>Diffuse large B-cell lymphoma with spindle cell morphology is a rare variant. We present the case of a 74-year-old male who initially presented with a right supraclavicular (lymph) node enlargement. Histological analysis showed a proliferation of spindle-shaped cells with narrow cytoplasms. An immunohistochemical panel was used to exclude other tumors, such as melanoma, carcinoma, and sarcoma. The lymphoma was characterized by a cell-of-origin subtype of germinal center B-cell-like (GCB) based on Hans’ classifier (CD10-negative, BCL6-positive, and MUM1-negative); EBER negativity, and the absence of BCL2, BCL6, and MYC rearrangements. Mutational profiling using a custom panel of 168 genes associated with aggressive B-cell lymphomas confirmed mutations in ACTB, ARID1B, DUSP2, DTX1, HLA-B, PTEN, and TNFRSF14. Based on the LymphGen 1.0 classification tool, this case had an ST2 subtype prediction. The immune microenvironment was characterized by moderate infiltration of M2-like tumor-associated macrophages (TMAs) with positivity of CD163, CSF1R, CD85A (LILRB3), and PD-L1; moderate PD-1 positive T cells, and low FOXP3 regulatory T lymphocytes (Tregs). Immunohistochemical expression of PTX3 and TNFRSF14 was absent. Interestingly, the lymphoma cells were positive for HLA-DP-DR, IL-10, and RGS1, which are markers associated with poor prognosis in DLBCL. The patient was treated with R-CHOP therapy, and achieved a metabolically complete response.</p> <p>Carreras J, Kikuti YY, Miyaoka M, Hiraiwa S, Tomita S, Ikoma H, Kondo Y, Ito A, Nagase S, Miura H, Roncador G, Colomo L, Hamoudi R, Campo E, Nakamura N. Mutational Profile and Pathological Features of a Case of Interleukin-10 and RGS1-Positive Spindle Cell Variant Diffuse Large B-Cell Lymphoma. <em>Hematology Reports</em>. 2023; 15(1):188-200. https://doi.org/10.3390/hematolrep15010020</p>
spindle cell variant diffuse large B-cell lymphoma (hematolrep-2136295)
<p>Diffuse large B-cell lymphoma with spindle cell morphology is a rare variant. We present the case of a 74-year-old male who initially presented with a right supraclavicular (lymph) node enlargement. Histological analysis showed a proliferation of spindle-shaped cells with narrow cytoplasms. An immunohistochemical panel was used to exclude other tumors, such as melanoma, carcinoma, and sarcoma. The lymphoma was characterized by a cell-of-origin subtype of germinal center B-cell-like (GCB) based on Hans’ classifier (CD10-negative, BCL6-positive, and MUM1-negative); EBER negativity, and the absence of BCL2, BCL6, and MYC rearrangements. Mutational profiling using a custom panel of 168 genes associated with aggressive B-cell lymphomas confirmed mutations in ACTB, ARID1B, DUSP2, DTX1, HLA-B, PTEN, and TNFRSF14. Based on the LymphGen 1.0 classification tool, this case had an ST2 subtype prediction. The immune microenvironment was characterized by moderate infiltration of M2-like tumor-associated macrophages (TMAs) with positivity of CD163, CSF1R, CD85A (LILRB3), and PD-L1; moderate PD-1 positive T cells, and low FOXP3 regulatory T lymphocytes (Tregs). Immunohistochemical expression of PTX3 and TNFRSF14 was absent. Interestingly, the lymphoma cells were positive for HLA-DP-DR, IL-10, and RGS1, which are markers associated with poor prognosis in DLBCL. The patient was treated with R-CHOP therapy, and achieved a metabolically complete response.</p> <p>Carreras J, Kikuti YY, Miyaoka M, Hiraiwa S, Tomita S, Ikoma H, Kondo Y, Ito A, Nagase S, Miura H, Roncador G, Colomo L, Hamoudi R, Campo E, Nakamura N. Mutational Profile and Pathological Features of a Case of Interleukin-10 and RGS1-Positive Spindle Cell Variant Diffuse Large B-Cell Lymphoma. <em>Hematology Reports</em>. 2023; 15(1):188-200. https://doi.org/10.3390/hematolrep15010020</p>
Zanubrutinib, in Combination With Lenalidomide, With or Without Rituximab in Participants With Relapsed/Refractory Diffuse Large B-Cell Lymphoma
ClinicalTrials.gov study NCT04436107. IPD Sharing: YES. Countries: 1. Publications: 0.
Treatment of CD79B Mutant Relapsed/Refractory Diffuse Large B-Cell Lymphoma With Bruton Tyrosine Kinase Inhibitor Zanubrutinib
ClinicalTrials.gov study NCT05068440. IPD Sharing: YES. Countries: 1. Publications: 0.
Phase III Study of RAD001 Adjuvant Therapy in Poor Risk Patients With Diffuse Large B-Cell Lymphoma (DLBCL) of RAD001 Versus Matching Placebo After Patients Have Achieved Complete Response With First-
ClinicalTrials.gov study NCT00790036. IPD Sharing: UNDECIDED. Countries: 34. Publications: 1.
Mapping of nanoparticles diffusion in cells
<p>We mapped the diffusion of particles in the cytoplasm. To do so, we electroporated QDs-SB particles in cells as shown in Debayle et al 2019. Here we were using RPE1 cells. We present the recording of three cells and the scripts that we used to generate some maps of diffusion in the cell.</p> <p>The scripts were made to use the output tracks from Slimfast 1.103e but can be adapted by changeing the beginning of the script.</p> <p>Some functions were found in Matlab Central and their corresponding license is in their respective folders.</p>
Diffusion of nanoparticles in the cell cytoplasm
<p>In Etoc 2018, we presented the diffusive behavior inside the cytosol of living cells for different kind of nanometric sized nanoparticles. We showed that the passivation of the particles is the main parameter that regulate the diffusion properties of particles smaller than 70nm not only in Hela cells but also in RPE1 and MSC cells.</p> <p>Here we open the data for the MSC cells.</p> <p>Experiments consists in the recording of small subregions of the cytoplasm located at the periphery of the cell.</p> <p>A README file is included in the archive with the recording parameters.</p> <p>DATA were recorded by Elie BALLOUL</p> <p>Scripts were written by Mathieu COPPEY, Fred ETOC and modified by Elie BALLOUL.(to use polyfit instead of ezyfit)</p> <p>We also make available the scripts that we used to generate the maps.</p> <p>Some functions were found in Matlab Central and their corresponding license is in their respective folders.</p>
Single Cell Phenotypic Profiling to Identify a Set of Immune Cell Protein Biomarkers for Relapsed and Refractory Diffuse Large B Cell Lymphoma: A Single-Center Study
<p>Diffuse large B-cell lymphoma (DLBCL) is the most common invasive type of non-Hodgkin lymphoma. Cell-of-origin (COO) classification is related to patients’ prognoses. Primary drug resistance in treatment for DLBCL has been observed. The specific serum biomarkers in these patients who suffer from relapsed and refractory (R/R)-DLBCL remains unclear. In the current study, using single-cell RNA sequencing (scRNA-seq) and mass cytometry (CyTOF), we determined and verified immune cell biomarkers at the mRNA and protein levels in single-cell resolution from 18 diagnostic peripheral blood mononuclear cell (PBMC) specimens collected from patients with R/R DLBCL. As controls, five PBMC specimens from healthy volunteers were obtained. We identified a panel of 35 surface marker genes for the features of R/R DLBCL unique cell cluster by scRNA-seq of eight R/R DLBCL patient samples and validated its efficiency in an external cohort consisting of 10 R/R DLBCL patients by CyTOF. The cell clustering and dimension reduction were compared among R/R DLBCL samples in CyTOF Space with COO as well as the C-MYC expression designation. Immune cells from each patient occupied unique regions in the 32-dimensional phenotypic space with no apparent clustering of samples into discrete subtypes. Significant heterogeneity observed in subgroups was mainly attributed to individual differences among samples and not to expression differences in a single, homogeneous immune cell subpopulation. The marker panel showed reliability in labeling R/R DLBCL without any influence from COO stratification and C-MYC expression designation. Furthermore, we compared all the markers between R/R DLBCL and normal samples. A total of 12 biomarkers were significantly overexpressed in R/R DLBCL relative to the normal samples. Therefore, we further optimized the diagnostic biomarker panel of R/R DLBCL comprising CD82, CD55, CD36, CD63, CD59, IKZF1, CD69, CD163, CD14, CD226, CD84, and CD31. In summary, we developed a novel set of biomarkers for the diagnoses of patients with R/R DLBCL. Detections procedures at single-cell resolution provide precise biomarkers which may substantially overcome intertumoral and intratumoral heterogeneity among primary samples. The findings confirmed that each case was unique and may comprise multiple, genetically distinct subclones.</p> <p>Here we uploaded the dataset of CyTOF for external validation. For more detailed information, please contact Dr zheng (zenki_zheng@163.com)</p> <p> </p>
Diffusive Dynamics of Bacterial Proteome as a Proxy of Cell Death
<p>This dataset accompanies the article entitled <em>Diffusive Dynamics of Bacterial Proteome as a Proxy of Cell Death</em>, published in ACS Cent. Sci. (<a href="https://doi.org/10.1021/acscentsci.2c01078">https://doi.org/10.1021/acscentsci.2c01078</a>).</p> <p><strong>subboxes_overview.xlsx: </strong>This spreadsheet contains information about the protein composition of each sub-box.</p> <p><strong>BOX_GEOMETRIES.zip: </strong>Starting structures (saved in Gromos87 .gro format) used for the production runs of the all-atom sub-boxes.</p> <p><strong>PROTEIN_COM_MSD.zip: </strong>Text files containing the mean square displacements (MSDs) of the centers of mass (COMs) of individual proteins, as obtained from the production runs of the all-atom sub-boxes. The time is shown in picoseconds while the MSD values are given in nm<sup>2</sup>. For each sub-box, the protein numbering corresponds to the subboxes_overview.xlsx spreadsheet.</p> <p><strong>CHAIN_COM_MSD.zip: </strong>Text files containing the mean square displacements (MSDs) of the centers of mass (COMs) of individual polypeptide chains, as obtained from the production runs of the all-atom sub-boxes. The time is shown in picoseconds while the MSD values are given in nm<sup>2</sup>. For each sub-box, the chain numbering corresponds to the subboxes_overview.xlsx spreadsheet.</p> <p><strong>CHAIN_ROTACF.zip: </strong>Text files containing the rotational autocorrelation functions for individual polypeptide chains, as obtained from the production runs of the all-atom sub-boxes. The time is shown in picoseconds; the autocorrelation functions were calculated using a second-order Legendre polynomial. For each sub-box, the chain numbering corresponds to the subboxes_overview.xlsx spreadsheet.</p>
Ibrutinib in Combination With Lenalidomide and Rituximab in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma
ClinicalTrials.gov study NCT02077166. IPD Sharing: YES. Countries: 4. Publications: 2.
A Trial in Patients With Diffuse Large-B-cell Lymphoma Comparing Pixantrone Against Doxorubicin
ClinicalTrials.gov study NCT00268853. IPD Sharing: Not stated. Countries: 5. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.