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80 results for “dipg”
Growth kinetics of the HSJD-DIPG-07 cell line in non-adherent culture
<p>The growth kinetics of the HSJD-DIPG-07 cell line when grown as neurospheres in non-adherent culture conditions.</p>
Optimisation of viability assay for DIPG patient-derived cell lines
<p>Evaluation of the efficacy of M4K compounds in DIPG patient-derived cell lines is essential before any promising compounds can be further tested in mouse xenograft models. This approach can aid in narrowing down clinical compound candidates and reduce the time, resources and animal sacrifice needed downstream.</p> <p>A robust and efficient readout for the changes in the viability of the DIPG cells needs to be established before it can be used to evaluate the M4K compounds. In addition, the amount of cells to be seeded at the beginning of the experiment has to be optimised to avoid overcrowding and starvation of the cells after extended culture times. Overcrowding and starvation will lead to increased cell death and prevent accurate estimation of the potency of M4K compounds (EC50).</p>
Different methods to evaluate the effects of M4K compounds on DIPG patient-derived cell lines
<p>Aside from determining the optimal numbers of DIPG cells to be seeded for viability assay, it is also important to validate that measurements using CellTiter Glo are in agreement with other methods of determining cell viability.</p> <p>For my blog post about this experiment, please visit my opennotebook page.</p> <p>https://openlabnotebooks.org/different-methods-to-evaluate-the-effects-of-m4k-compounds-on-dipg-patient-derived-cell-lines/</p>
Evaluating the effect of 8 M4K compounds on the viability of DIPG patient-derived cells (SU-DIPG-VI, HSJD-DIPG-007 and SU-DIPG-IV)
<p>Viability assay using Celltiter Glo kit has been chosen as the main method for evaluating the efficacy of ALK2 inhibitors on DIPG patient-derived cells due to its robustness. As a pilot experiment, 8 ALK2 inhibitors with differing potencies were chosen and evaluated in 3 DIPG patient-derived cell lines (one with wild-type ALK2 and two with mutant ALK2).</p>
H3.3K27M Peptide Vaccine With Nivolumab for Children With Newly Diagnosed DIPG and Other Gliomas
ClinicalTrials.gov study NCT02960230. IPD Sharing: NO. Countries: 2. Publications: 1.
Hypofractionated Radiotherapy for Recurrent DIPG
ClinicalTrials.gov study NCT03841435. IPD Sharing: NO. Countries: 1. Publications: 16.
Molecularly Determined Treatment of Diffuse Intrinsic Pontine Gliomas (DIPG)
ClinicalTrials.gov study NCT01182350. IPD Sharing: NO. Countries: 1. Publications: 1.
Study of the Combination of Crizotinib and Dasatinib in Pediatric Research Participants With Diffuse Pontine Glioma (DIPG) and High-Grade Glioma (HGG)
ClinicalTrials.gov study NCT01644773. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication
ClinicalTrials.gov study NCT02233049. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Abemaciclib in Children With DIPG or Recurrent/Refractory Solid Tumors
ClinicalTrials.gov study NCT02644460. IPD Sharing: NO. Countries: 1. Publications: 1.
Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG
ClinicalTrials.gov study NCT04049669. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Evaluating the inhibition of ALK2 phosphorylation of SMAD1/5 by M4K lead compounds in DIPG patient-derived cells (SU-DIPG-IV, HSJD-DIPG-007, HSJD-DIPG-018 and SU-DIPG-XXI)
<p>The binding potency of M4K compounds to ALK2 has been assayed in biochemical assay and cellular assays in HEK293 or C2C12 myoblast cell lines. However, the potency of ALK2 inhibition by M4K compounds has not determined directly in DIPG patient-derived cell lines. While no major deviation from existing assay data is expected, direct experimental evidence is essential.</p> <p>DIPG cells will be trypsinized and resuspended in TSM-base medium without any growth factor for one-hour starvation. Subsequently, equal volume of TSM-base with 2X Activin A (200ng/mL) and M4K compounds or DMSO vehicle control will be added. After one-hour treatment, the cells will be pelleted and lysed in buffer with protease and phosphatase inhibitors for Western Blot analysis.</p> <p>For other related studies, please refer to my opennotebook blog.</p> <p><a href="https://openlabnotebooks.org/evaluating-the-inhibition-of-alk2-phosphorylation-of-smad1-5-by-m4k-lead-compounds-in-dipg-patient-derived-cells-su-dipg-iv-hsjd-dipg-007-hsjd-dipg-018-and-su-dipg-xxi/">https://openlabnotebooks.org/evaluating-the-inhibition-of-alk2-phosphorylation-of-smad1-5-by-m4k-lead-compounds-in-dipg-patient-derived-cells-su-dipg-iv-hsjd-dipg-007-hsjd-dipg-018-and-su-dipg-xxi/</a></p>
International Diffuse Intrinsic Pontine Glioma (DIPG)/Diffuse Midline Glioma (DMG) Registry and Repository
ClinicalTrials.gov study NCT03101813. IPD Sharing: YES. Countries: 1. Publications: 0.
A Study of Ad-RTS-hIL-12 + Veledimex in Pediatric Subjects With Brain Tumors Including DIPG
ClinicalTrials.gov study NCT03330197. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Phase I Study of Marizomib + Panobinostat for Children With DIPG
ClinicalTrials.gov study NCT04341311. IPD Sharing: YES. Countries: 1. Publications: 0.
Non-inflammatory tumor microenvironment of Diffuse Intrinsic Pontine Glioma (DIPG)
GEO Series GSE115397. Homo sapiens. 13 samples. Type: Expression profiling by high throughput sequencing.
Re-programing chromatin with a bifunctional LSD1/HDAC inhibitor induces therapeutic differentiation in DIPG
GEO Series GSE110572. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Epigenetic changes in human DIPG cells with histone H3K27M mutations [ATAC-seq]
GEO Series GSE135418. Homo sapiens. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Inhibition of SP/KLF transcription regulatory network and histone deacetylases acts synergistically against H3K27M-DIPG
GEO Series GSE255013. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
3D Tumor Tissue Analogs: Tumor Microenvironment and Therapeutic Implications in DIPG
GEO Series GSE222891. Homo sapiens. 11 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.