Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
768
datasets available to search
ShareScore release 0.9.0
Dataset results
768 results for “disease control”
Smartphone sensor data (accelerometer, virtual keyboard) collected in-the-wild by Parkinson's Disease patients and Healthy Controls
<p>For detailed description of the dataset see the relevant <a href="https://www.nature.com/articles/s41598-020-78418-8">journal article</a>.</p> <p>Python code for model inference and training is available <a href="https://github.com/alpapado/deep_pd">here</a>.</p> <p> </p> <p><strong>DESCRIPTION</strong></p> <p>The dataset contains accelerometer recodings and keyboard typing data contributed by Parkinson's Disease patients and Healthy Controls. Accelerometer data consists of acceleration values recorded during phone calls and typing data consist of virtual keyboard press and release timestamps. The dataset is divided into two parts: the first part, called SData, contains data from a small, medically evaluated, set of users, while the second part, called GData, contains recordings from a large body of users with self-reported PD labels.</p> <p>The dataset is organized into 5 pickle files:</p> <p>1. <strong>imu_sdata.pickle</strong>: Contains the tri-axial accelerometer recordings for the SData part of the dataset in the form of a list of python dictionaries, one for each participating subject. Accelerometer data have been pre-processed to a sampling frequency of 100Hz and come segmented into non-overlapping 5 second windows. Hence, a segment's dimension will be 500 x 3 samples.</p> <p>Sample Python code for accessing the acceleration data of a subject</p> <pre><code class="language-python">sdata = pickle.load(open('imu_sdata.pickle', 'rb')) subject_list = list(sdata.keys()) ## Data for first subject subject_data = sdata[subject_list[0]] # subject_data is a list of length 4 ## The actual data is in the last element of the list acc_segments = subject_data[-1] num_acc_sessions_for_subject = len(acc_segments) acc_segments_for_first_session = acc_segments[0] acc_segments_for_second_session = acc_segments[1] # ..etc In: print(acc_segments_for_first_session.shape) Out: (3, 500, 3) ## The first accelerometer session for this subject consists of 3 five-second segments. In: print(acc_segments_for_second_session.shape) Out: (8, 500, 3) ## The second accelerometer session for this subject consists of 8 five-second segments.</code></pre> <p>2. <strong>imu_gdata.pickle</strong>: Same layout as imu_sdata.pickle but with data ffrom GData subjects.</p> <p>3. <strong>typing_sdata.pickle</strong>: This files contains the typing data originating from the SData part of the dataset. It is a list of dictionaries with one entry per subject. The typing data are given in the form of concatenated hold time (the time elapsed between press and release of the virtual key) and flight time (the time between releasing a key and press the next) histograms, computed over 10ms bins in the range of [0, 1]s for hold time and [0, 4]s for flight time (an additional bin that contains the values in the (1, +oo) and (4, +oo) intervals is also used). So, the total length of the concatenated histogram is 1000/10 + 1 + 4000/10 + 1 = 502.</p> <p>Sample Python code for accessing the typing data of a subject:</p> <pre><code class="language-python">sdata = pickle.load(open('typing_sdata.pickle', 'rb')) subject_list = list(sdata.keys()) ## Data for first subject subject_data = sdata[subject_list[0]] ## The actual data is in the first element of the list typing_histograms = subject_data[0] num_typing_sessions_for_subject = len(typing_histograms) typing_hist_for_first_session = typing_histograms[0] typing_hist_for_second_session = typing_histograms[1] # ..etc In: print(typing_hist_for_first_session.shape) Out: (502, ) ht_hist = typing_hist_for_first_session[:101] # Hold time histogram of the session ft_hist = typing_hist_for_first_session[101:] # Flight time histogram of the session</code></pre> <p>4. <strong>typing_gdata.pickle</strong>: Same layout as typing_sdata.pickle but with data from GData subjects.</p> <p>5. <strong>subject_metadata.pickle</strong>: A list of dictionaries with one entry per subject containing demographic information. The relevant demographic fields have the following interpretation:<br> 'age': Year of birth,<br> 'gender_id': 0 indicates male, 1 indicates female<br> 'healthstatus_id': 0 indicates PD patient, 1 indicates Healthy with PD family history, 2 indicates Healthy without PD family history</p> <p>In the case of SData subjects, there is also symptom UPDRS scores from one or two medical examinations. These are ncoded in the fields med_eval_1 and med_eval_2.</p> <p> </p> <p><strong>ETHICS & FUNDING</strong></p> <p>The study during which the present dataset was collected is a multi-center study approved in each country available (for more info visit: <a href="http://www.i-prognosis.eu/?page_id=3606">http://www.i-prognosis.eu/?page_id=3606</a>). Informed consent, including permission for third-party access to pseudo-anonymised data, was obtained from all subjects prior to their engagement with the study. The work has received funding from the European Union's Horizon 2020 research and innovation programme under Grant Agreement No 690494 - i-PROGNOSIS: Intelligent Parkinson early detection guiding novel supportive interventions (<a href="http://www.i-prognosis.eu/">i-prognosis.eu</a>).</p> <p> </p> <p><strong>CORRESPONDANCE</strong></p> <p>Any inquiries regarding this dataset should be adressed to:</p> <p>Mr. Alexandros Papadopoulos (Electrical & Computer Engineer, PhD candidate)</p> <p>Multimedia Understanding Groupmug<br> Department of Electrical & Computer Engineering<br> Aristotle University of Thessaloniki<br> University Campus, Building C, 3rd floor<br> Thessaloniki, Greece, GR54124</p> <p>Tel: +30 2310 996359, 996365 <br> Fax: +30 2310 996398<br> E-mail: alpapado@mug.ee.auth.gr</p> <p> </p> <p><br> </p> <p> </p>
IMU data captured unobtrusively and in-the-wild by Parkinson's disease patients and healthy controls
<p><strong>DATASET</strong></p> <p>The dataset contains IMU signals captured in-the-wild via the accelerometer sensor embedded in modern smartphones, for the purpose of detecting tremorous episodes, related to Parkinson's Disease (PD). A group of 31 PD patients and 14 Healthy controls contributed accelerometer data using their personal smartphones, for a period spanning many months.Tri-axial acceleration values were recorded automatically whenevera phone call was realized. The recording lasted for 75 seconds at the most. Each phone call thus resulted in one recorded accelerometer signal, also referred to as session. Each subject contributed a different amount of sessions depending on the number of phone calls they realized during the data collection period as well as their participation time (they were free to drop-out at any time). A detailed description of the capturing process as well as analysis results, can be found in the related research article.</p> <p>The data is presented as a list of python dictionaries, stored in a pickle file. Each dictionary in the list, corresponds to one subject and containes the following fields:</p> <p>1. subject_id: scalar<br> A numerical value that uniquely identifies the subject.</p> <p>2. subject_sessions: list of numpy.array<br> A list of numpy arrays of shape (N, 4) that contains the tri-axial accelerometer sessions that the subject contributed. N denotes the total length of the session in samples (which varies from session to session) Column 0 of the array contains the timestamps of the accelerometer samples. Columns 1-3 contain the acceleration values across the x,y,z directions.</p> <p>3. session_datetimes: list of datetime objects <br> A list of datetime objects that denote the capturing date and time of the corresponding entries in the subject_sessions field.</p> <p>4. annotation: dict<br> A dictionary containing the following tremor-related annotation values:<br> * updrs16: scalar int<br> The value related to tremor as described in item 16 of the part II of the MDS-UPDRS scale, as reported by the subject.</p> <p>* updrs20_right: scalar int in range [0, 4]<br> The value related to rest tremor in the right hand as described in item 20 of the part III of the MDS-UPDRS scale, as reported by the attending neurologist.</p> <p>* updrs20_left: scalar int in range [0, 4]<br> Same as above but for left hand.</p> <p>* updrs21_right: scalar int in range [0, 4]<br> The value related to action/postural tremor in the right hand as described in item 21 of the part III of the MDS-UPDRS scale, as reported by the attending neurologist.</p> <p>* updrs21_left: scalar int in range [0, 4]<br> Same as above but for left hand.</p> <p>* sp_expert: scalar int in range [0, 1]<br> A binary tremor annotation created by a group of signal processing experts, upon visually examining the contributed signals in both time and frequency domain and taking into consideration the UDPRS scores of each subject. This was necessary due to the intermittent nature of tremor, as well as a number of considerations related to the in-the-wild nature of the data capturing process. For more details, we refer the reader to the dataset description in the related research article.<br> A '1' value indicates that the subject has tremor.<br> A '0' value indicates that the subject doesn't have tremor.</p> <p>* pd_status: scalar int in range [0, 1]<br> A '1' value indicates that the subject is a PD patient.<br> A '0' value indicates that the subject is a Healthy Control</p> <p>Note: Each annotation value refers to the subject as a whole, and not in any one session.<br> </p> <p><strong>ETHICS & FUNDING</strong></p> <p>The study during which the present dataset was collected is a multi-center study approved in each country available (for more info visit: <a href="http://www.i-prognosis.eu/?page_id=3606">http://www.i-prognosis.eu/?page_id=3606</a>). Informed consent, including permission for third-party access to pseudo-anonymised data, was obtained from all subjects prior to their engagement with the study. The work has received funding from the European Union's Horizon 2020 research and innovation programme under Grant Agreement No 690494 - i-PROGNOSIS: Intelligent Parkinson early detection guiding novel supportive interventions (<a href="http://www.i-prognosis.eu/">i-prognosis.eu</a>).</p> <p> </p> <p><strong>CORRESPONDANCE</strong></p> <p>Any inquiries regarding this dataset should be adressed to:</p> <p>Mr. Alexandros Papadopoulos (Electrical & Computer Engineer, PhD candidate)</p> <p>Multimedia Understanding Groupmug<br> Department of Electrical & Computer Engineering<br> Aristotle University of Thessaloniki<br> University Campus, Building C, 3rd floor<br> Thessaloniki, Greece, GR54124</p> <p>Tel: +30 2310 996359, 996365 <br> Fax: +30 2310 996398<br> E-mail: alpapado@mug.ee.auth.gr</p> <p> </p> <p><strong>LICENSE</strong></p> <p>This is an open access dataset, licensed under Creative Commons Attribution 4.0 International (<a href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</a>).</p> <p> </p> <p><strong>WARRANTY</strong></p> <p>This dataset comes without any warranty. Administrators of this dataset can not be held accountable for any damage (physical, financial or otherwise) caused by the use of this dataset. </p>
Dataset: Co-composting rose waste as a sustainable waste management strategy: Nutrient availability and disease control
<p>This dataset and these scripts supports the article 'Assessing the potential of co-composting rose waste as a sustainable waste management strategy: Nutrient availability and disease control' as published in Journal of Cleaner production. https://doi.org/10.1016/j.jclepro.2023.136685</p> <p>Roses are an important crop for the floricultural sector of Kenya and roses are a perennial crop and under continuous production for six to ten years. The cultivation produces large quantities of green waste, up to 50 kg per hectare per day. In this experiment we investigated the potential of co-composting rose waste on a small scale. The objective was to increase the understanding of composting lignocellulosic rose waste, which will help with the implementation of composting practices within Kenyan rose production and thereby reduce its negative ecological impact.</p> <p>In a small-scale composting system (30L) the evolution of five mixtures was closely monitored in terms of their physico-chemical parameters. Furthermore, the in-vitro disease suppressive capacity of mature rose waste was assessed. </p>
SFB1451 - key mechanisms of motor control in health and disease
<p>Note: this dataset has been deprecated in favour of <a href="https://github.com/sfb1451/all-datasets" target="_blank" rel="noopener">sfb1451/all-datasets</a>; see <a href="https://doi.org/10.5281/zenodo.11119424">10.5281/zenodo.11119424</a><br><br>This dataset indexes projects of the Collaborative Research Centre 1451 (CRC1451; dt: Sonderforschungsbereich, SFB1451). This collaborative research centre brings together neuroscientists investigating genetic factors, cellular, and synaptic as well as systems/neural network processes underlying motor control in animals and humans, in both health and neuropsychiatric diseases. All investigators are committed to the CRC's multi-faceted, iterative, and integrative agenda with the long-term goal of identifying the essential mechanisms underlying normal and pathological motor control.</p>
SFB1451 - key mechanisms of motor control in health and disease
This is a collection of datasets created within the Collaborative Research Center 1451. The "superdataset" contains information about datasets stored in various locations. This information can be used to obtain programmatic, fine-grained data access to the level of individual files, depending on the level of detail provided by dataset authors, storage location, and access restrictions. The Collaborative Research Center 1451 (CRC1451; dt: Sonderforschungsbereich, SFB1451) brings together neuroscientists investigating genetic factors, cellular, and synaptic as well as systems/neural network processes underlying motor control in animals and humans, in both health and neuropsychiatric diseases. All investigators are committed to the CRC's multi-faceted, iterative, and integrative agenda with the long-term goal of identifying the essential mechanisms underlying normal and pathological motor control.
Dataset Natural plant disease suppressiveness in soils extends to insect pest control
<p>This dataset is related to the study "<strong>Natural plant disease suppressiveness in soils extends to insect pest control</strong>" (Harmsen et al., 2024) and contains the raw data described therein. </p> <p>Sequencing data used in this study has been deposited in the NCBI Sequence Read Archive under the BioProject number <a href="https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1075215/">PRJNA1075215</a>.</p> <p>The scripts used to analyze the data generated in the study are available at <a href="https://github.com/nhrmsn/SuppressSoil-Data">GitHub</a>. </p>
Keystroke timing and pressure data captured during touchscreen typing by early Parkinson's disease patients and healthy controls
<p><strong>DATASET</strong></p> <p>The present dataset comprises keystroke timing and pressure data that correspond to short text excerpts typed by early Parkinson’s disease (PD) patients (n=18) and healthy controls (n=15) on a common touchscreen-equipped smartphone (LG Nexus 5X with a screen of 5.2 inches in diagonal and a resolution of 1080 × 1920 pixels, running native Android 7.0). Subjects were asked to transcribe up to 11 short text excerpts, with the initial one being 200 characters-long and common for all subjects, while the rest were 40-115 characters-long, pseudorandomly drawn from the fairy tale 'The Little Prince'. Data were recorded using a custom Android Operating System input method (keyboard), developed for the purposes of the study. Additional details on exepriment design, material and methods can be found in the related research article mentioned below. </p> <p>Data consist of sequences of raw press and release timestamps (in milliseconds), as well as of values of normalized pressure (0.000-1.000) applied to initiate keystrokes, corresponding to the consecutive keys tapped during the transcription of each text excerpt. Data included in the 'Data' folder are organised in sub-folders per subject. Each sub-folder contains a number of .txt files with each one corresponding to a text excerpt typed by the particular subject. Files are named using the format S##_TEX##.txt, with S## denoting the subject's coded ID and TEX## the serial number of the transcribed text excerpt. For all subjects, file S##_TEX01.txt corresponds to the initial and common 200 characters-long text excerpt. Each file contains the sequences of raw key press/release timestamps (Tp#, Tp#) and normalized pressure (NP#), applied to initiate each keystroke, in the following format:</p> <p>{<br> Press, Tp1, Release, Tr1, NP1<br> Press, Tp2, Release, Tr2, NP2<br> .<br> .<br> . <br> Press, Tpn, Release, Trn, NPn<br> }</p> <p>where 1,2,...,n denote the serial index of the key tapped during typing.</p> <p><em>Note:</em> Out of 33 subjects, 32 managed to transcribe 8 to 11 text excerpts, while the remaining one (Subject ID: 16) typed only 5. Ten subjects (Subject IDs: 6, 14, 16, 17, 25, 27, 29, 31, 32, 33) did not manage to type the initial 200 characters-long excerpt in its entirety.</p> <p>The dataset also includes a record, in Microsoft Excel format (Demographics_Clinical_Characteristics.xlsx), of the demographic and clinical characteristics (with respect to PD) of subjects. Entries of the Excel file are linked to subjects' sub-folders and individual keystroke data text files via the coded ID of the subject.</p> <p>Demographic characteristics included:</p> <p>Age; Gender; Education level; Years of smartphone usage; Dominant hand<sup>1</sup></p> <p>Clinical characteristics included:</p> <p>Group (PD, Control); Years from diagnosis; Hoehn-Yahr disease stage; Most affected side<sup>2</sup>; Levodopa Equivalent Daily Dose; UPDRS_III<sup>3</sup> total score; UPDRS_III Item 21 Tremor-Right hand; UPDRS_III Item 21 Tremor-Left hand; UPDRS_III Item 22 Rigidity-Right hand; UPDRS_III Item 22 Rigidity-Left hand; UPDRS_III Item 23 Finger taps-Right hand; UPDRS_III Item 23 Finger taps-Left hand; UPDRS_III Item 31 Body bradykinesia/ Hypokinesia</p> <p><sup>1</sup>Dominant hand: (Relating to handedness) the operant hand generally used for performing fine motor-skills tasks.<br> <sup>2</sup>Most affected body side by Parkinson's disease<br> <sup>3</sup>UPDRS_III: Unified Parkinson's Disease Rating Scale Part III (Motor section)</p> <p> </p> <p><strong>RELATED RESEARCH</strong></p> <p>This dataset was originally used and described in the OPEN ACCESS publication: </p> <p>[1] Iakovakis, D., Hadjidimitriou, S., Charisis, V., Bostantzopoulou, S., Katsarou, Z., & Hadjileontiadis, L. J. (2018). Touchscreen typing-pattern analysis for detecting fine motor skills decline in early-stage Parkinson’s disease. Scientific reports, 8(1), 7663. <a href="http://doi.org/10.1038/s41598-018-25999-0">https://doi.org/10.1038/s41598-018-25999-0</a> </p> <p>All documents and papers that report on research that uses this dataset will acknowledge this by citing the above publication.</p> <p> </p> <p><strong>ETHICS & FUNDING</strong></p> <p>The study during which the present dataset was collected was approved by the Aristotle University of Thessaloniki Bioethics Committee of Medical School (approval no. 359/3.4.17), Thessaloniki, Greece. Informed consent, including permission for third-party access to pseudo-anonymised data, was obtained from all subjects prior to their engagement with the study. The work has received funding from the European Union's Horizon 2020 research and innovation programme under Grant Agreement No 690494 - i-PROGNOSIS: Intelligent Parkinson early detection guiding novel supportive interventions (<a href="http://www.i-prognosis.eu">i-prognosis.eu</a>).</p> <p> </p> <p><strong>CORRESPONDANCE</strong></p> <p>Any inquiries regarding this dataset should be adressed to:</p> <p>Mr. Dimitrios Iakovakis (Electrical & Computer Engineer, PhD candidate)</p> <p>Signal Processing & Biomedical Technology Unit<br> Department of Electrical & Computer Engineering<br> Aristotle University of Thessaloniki<br> University Campus, Building D, 6th floor<br> Thessaloniki, Greece, GR54124</p> <p>Tel: +30 2310 996319<br> Fax: +30 2310 996312<br> E-mail: dimiiako12@gmail.com</p> <p> </p> <p><strong>LICENSE</strong></p> <p>This is an open access dataset, licensed under Creative Commons Attribution 4.0 International (<a href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</a>).</p> <p> </p> <p><strong>WARRANTY</strong></p> <p>This dataset comes without any warranty. Administrators of this dataset can not be held accountable for any damage (physical, financial or otherwise) caused by the use of this dataset. </p>
Video Series: Integrated Pest Management focusing on disease control in cereals
<p>Welcome to this video series on IPM, focusing on disease control in cereals. </p> <p>The challenge of IPM is to make the control methods we use appropriate to the circumstances, and to balance between the productivity of the crop and minimising the impact on the environment. The control decisions we make on one field or in one season may not be appropriate in another set of circumstances – there is no ‘blue print’. In these videos we delve into the physiology of the crop, the epidemiology of the diseases and how different control methods work. By understanding the biology of the systems we're trying to control, we're better equipped to make appropriate decisions. Going into depth means we can’t cover all aspects of IPM. In practice, decisions about disease control are being made alongside decisions about invertebrate pests and weeds, and in the wider context of integrated crop management. In the UK, information on those topics is available from organisations such as LEAF, AHDB and the Voluntary Initiative. Nevertheless, disease control is still a big topic, so we have broken it down into bite size chunks - although each video is still a pretty substantial bite and will need some digesting.</p> <p>The videos can be viewed in any order that interests you, but they'll make most logical sense viewed in the order in the menu.</p> <p>Links to the videos can be found in the summary document. </p> <p>PDF versions of the video presentations are provided. </p>
Visual perturbation of balance suggests impaired motor control but intact visuomotor processing in Parkinson's disease, J Neurophysiol (2021): Data
<p>Data set accompanying the publication:</p> <p>Engel, D., Student, J., Schwenk, J., Morris, A. P., Waldthaler, J., Timmermann, L., & Bremmer, F. (2021). Visual perturbation of balance suggests impaired motor control but intact visuomotor processing in Parkinson's disease. <em>Journal of neurophysiology</em>, <em>126</em>(4), 1076–1089. https://doi.org/10.1152/jn.00183.2021</p>
Data from Comparative effectiveness of common therapies for Wilson disease: A systematic review and meta‐analysis of controlled studies
<p>This dataset contains three text files in RIS format. They represent the screening process during study selection for "Comparative effectiveness of common therapies for Wilson disease: A systematic review and meta‐analysis of controlled studies" (<a href="https://doi.org/10.1111/liv.14179">https://doi.org/10.1111/liv.14179</a>). The file DOKU_All TiAb-Screening_20200116_cap contains all 3453 records (merged from original and update search) that were subjected to title-abstract screening. The file DOKU_All FT-Screening_20200116_cap contains all 174 records that were subjected to full-text screening. The file DOKU_All Included_20200116_cap contains all 26 records that were included into the final review.</p> <p>In addition, a PRISMA flow diagram (Fig. 1 in the paper) is available in TIF format.</p>
Data from: Fluorescent biomarkers demonstrate prospects for spreadable vaccines to control disease transmission in wild bats
Vaccines that autonomously transfer among individuals have been proposed as a strategy to control infectious diseases within wildlife populations. However, understanding rates of spread and epidemiological efficacy in real world systems remain elusive. Here, we investigated whether topical vaccines that transfer among bats through social contacts can control vampire bat rabies, a medically and economically important zoonosis in Latin America. Field experiments in 3 Peruvian bat colonies which used fluorescent biomarkers as a proxy for the bat-to-bat transfer and ingestion of an oral vaccine revealed that vaccine transfer would increase population-level immunity up to 2.6 times beyond the same effort using conventional, non-spreadable vaccines. Mathematical models demonstrated that observed levels of vaccine transfer would reduce the probability, size, and duration of rabies outbreaks, even at low, but realistically achievable levels of vaccine application. Models further predicted that existing vaccines provide substantial advantages over culling bats, the policy currently implemented in North, Central, and South America. Linking field studies with biomarkers to mathematical models can inform how spreadable vaccines may combat pathogens of health and conservation concern prior to costly investments in vaccine design and testing.
Mobile Device Voice Recordings at King's College London (MDVR-KCL) from both early and advanced Parkinson's disease patients and healthy controls
<p><strong>Dataset description</strong></p> <p>The dataset description will start with describing the local conditions and other metadata, then will continue with describing the recording procedure and annotation methodology. Finally, a brief description of the dataset deployment and publication will be given.</p> <p><strong>Meta Information</strong></p> <p>The dataset was recorded at King's College London (KCL) Hospital, Denmark Hill, Brixton, London SE5 9RS in the period from 26 to 29 September 2017. We used a typical examination room with about ten square meters area and a typical reverberation tome of approx. 500ms to perform the voice recordings. Due to the fact, that the voice recordings are performed in the realistic situation of doing a phone call (i.e. participant holds the phone to the preferred ear and microphone is in direct proximity to the mouth), one can assume that all recordings were performed within the reverberation radius and thus can be considered as “clean”.</p> <p><strong>Recording Procedure</strong></p> <p>We used a Motorola Moto G4 Smartphone as recording device. To perform the voice recordings on the device, we developed a “Toggle Recording App”, which uses the same functionalities as the voice recording module used within the i-PROGNOSIS Smartphone application, but deployed as a standalone android application. This means, that the voice capturing service runs as a standalone background service on the recording device and triggers voice recordings via on- and off-hook signals of the Smartphone. Due to the fact, that we directly record the microphone signal, and not the GSM (“Global System for Mobile Communications”) compressed stream, we end up with high quality recordings with a sample rate of 44.1 kHz and a bit depth of 16 Bit (audio CD quality). The raw, uncompressed data is directly written to the external storage of the Smartphone (SD-card) using the well-known WAVE file format (.wav). We used the following workflow to perform a voice recording:</p> <ul> <li>Ask the participant to relax a bit and then to make a phone call to the test executor (off-hook signal triggered).}</li> <li>Ask the participant to read out “The North Wind and the Sun”</li> <li>Depending on the constitution of the participant either ask to read out “Tech. Engin. Computer applications in geography snippet”</li> <li>Start a spontaneous dialog with the participant, the test executor starts asking random questions about places of interest, local traffic, or personal interests if acceptable.</li> <li>Test executor ends call by farewell (on-hook signal triggered).</li> </ul> <p><strong>Annotation Scheme</strong></p> <p>For each HC and PD participant, we labeled the data regarding scores on the Hoehn & Yahr (H&Y), as well as the UPDRS II part 5 and UPDRS III part 18 scale. The voice recordings are labeled in the following scheme:</p> <p>SI_ HS_ HYR_ UPDRS II-5_UPDRS III-18</p> <p>with</p> <ul> <li>SI as subject identification in the form ID<em>NN</em>, <em>N</em> in [0, 9]</li> <li>HS as the health status label (hc or pd accordingly)</li> <li>HYR as the expert assessed H&Y scale rating</li> <li>UPDRS II-5 as the according expert peer-reviewed score</li> <li>UPDRS III-18 as the according expert assessed score</li> </ul> <p>For example, an audio recording with the file name “ID02_pd_1_2_1.wav” represents a recording of the third participant (First participant was anonymized as ID00), which has PD and a H&Y rating of 1, a UPDRS II-5 score of 2 and a UPDRS III-18 score of 1. At this point, it should be noted, that also all healthy controls were evaluated with regard to the introduced scales, because Parkinson's disease and voice degradation correlate, but don't match exactly. This means, that the data set includes one HC participant (ID31) with UPDRS II-5 and III-18 rating of 1, and also includes PD patients with UPDRS II-5 and III-18 ratings of 0. It should be emphasized, that this does not mean the data set includes ambiguous information, but that an expert was not able to hear voice degradation that would end up in a UPDRS rating greater than zero. Machine learning approaches may be able to nevertheless classify correctly, or at least learn to correlate, but not match PD and voice degradation at any time.</p> <p><strong>Appendix</strong></p> <p>North Wind and the Sun (Orthographic Version):</p> <p>“The North Wind and the Sun were disputing which was the stronger, when a traveler came along wrapped in a warm cloak. They agreed that the one who first succeeded in making the traveler take his cloak off should be considered stronger than the other. Then the North Wind blew as hard as he could, but the more he blew the more closely did the traveler fold his cloak around him; and at last the North Wind gave up the attempt. Then the Sun shone out warmly, and immediately the traveler took off his cloak. And so the North Wind was obliged to confess that the Sun was the stronger of the two.”</p> <p>BNC – Tech. Engin. Computer applications in geography snippet:</p> <p>“[...] This is because there is less scattering of blue light as the atmospheric path length and consequently the degree of scattering of the incoming radiation is reduced. For the same reason, the sun appears to be whiter and less orange-coloured as the observer's altitude increases; this is because a greater proportion of the sunlight comes directly to the observer's eye. Figure 5.7 is a schematic representation of the path of electromagnetic energy in the visible spectrum as it travels from the sun to the Earth and back again towards a sensor mounted on an orbiting satellite. The paths of waves representing energy prone to scattering (that is, the shorter wavelengths) as it travels from sun to Earth are shown. To the sensor it appears that all the energy has been reflected from point P on the ground whereas, in fact, it has not, because some has been scattered within the atmosphere and has never reached the ground at all. [...]”</p>
All data for the preprint Population genetics of Glossina palpalis gambiensis in the sleeping sickness focus of Boffa (Guinea) before and after eight years of vector control: no effect of control despite a significant decrease of human exposure to the disease
<p>Data set for the paper titled "Population genetics of <em>Glossina palpalis gambiensis</em> in the sleeping sickness focus of Boffa (Guinea) before and after eight years of vector control: no effect of control despite a significant decrease of human exposure to the disease"</p>
Assessment of Glycemic Control in Patients With Type 2 Diabetes Mellitus and Late Stage Chronic Kidney Disease
ClinicalTrials.gov study NCT03383627. IPD Sharing: NO. Countries: 1. Publications: 4.
Randomized, Controlled, Open-label, Multicenter, Safety and Efficacy Study of rhHNS Administration Via an IDDD in Pediatric Patients With Early Stage MPS IIIA Disease
ClinicalTrials.gov study NCT02060526. IPD Sharing: YES. Countries: 8. Publications: 1.
Fluorescent biomarkers demonstrate prospects for spreadable vaccines to control disease transmission in wild bats
Open the record for dataset details and reuse information.
Host controls of within-host disease dynamics: insight from an invertebrate system
Open the record for dataset details and reuse information.
Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course
Open the record for dataset details and reuse information.
Alzheimer's Disease versus Bipolar Disorder versus Health Control MRI data and processed results
<p><strong>README</strong></p> <p>The data is structured as follows:</p> <p>Clinical_data folder contains the .csv that can be read by spreadsheet software, as well as from Python, Matlab or R. There are separate files for each biomarker. The file "clinical_data_id_age_gender.csv" contains the numerical random key of the patient for anonymity, diagnostic key, age and gender for each entry in the other files. The file "clinical_data_corrected.csv" can be ignored.</p> <p>Diagnostic keywords: "crl" == healthy control, "tb" == bipolar disorder, "ea" == Alheimer's disease</p> <p>Imaging data is nifti encoded. The name of the file starts with the diagnostic key followed by the numerical random key and some nemotechnic for the contents. For instance: "crl_132_diff_dti_FA_FA_to_target.nii.gz" is the spatially normalized FA data of healthy control 132. Imaging data can be read with FSL, SPM, and any other nifti reading soft.</p> <p>Imaging folders contain the following data<br> DWI_origin - > the original diffusion weighted MRI data and their corresponding b-vector values</p> <p>FA - > the FA coefficients computed using FSL</p> <p>FA_to_target - > the FA volumes registered to MNI template using FSL tools</p> <p>T1_preprocessed - > the T1-weighted volumes at 1mm resolution registered to the MNI template using FSL no-linear registration tools</p> <p>T1_VBM_SPM_1mm - > the results of applying SPM implementation of voxel based morphometry (VBM) on the T1-weighted data, including results of the correlation between biomarkers and the detected clusters . Results can be checked using SPM (https://www.fil.ion.ucl.ac.uk/spm/)</p> <p>TBSS_results -> contains track based spatial statistics (TBSS) results obtained with FSL software (https://fsl.fmrib.ox.ac.uk/fsl/fslwiki/TBSS)</p> <p> </p> <p><strong>Publications using this dataset</strong></p> <p>M. Graña, M. Termenon, A. Savio, A. Gonzalez-Pinto, J. Echeveste, J. M. Pérez, A. Besga, Computer Aided Diagnosis system for Alzheimer Disease using brain Diffusion Tensor Imaging features selected by Pearson’s correlation, Neuroscience letters,Volume 502, Issue 3, 20 September 2011, Pages 225-229</p> <p>A. Besga, M. Termenon, M. Graña, J. Echeveste, J. M. Perez, A. Gonzalez-Pinto "Discovering Alzheimer's disease and bipolar disorder white matter effects building computer aided diagnostic systems on brain diffusion tensor imaging features, <strong>Neuroscience Letters</strong>, Volume 520, Issue 1, 27 June 2012, Pages 71–76.</p> <p>M. Termenon, M. Graña, A. Besga, J. Echeveste, A. Gonzalez-Pinto, Lattice Independent Component Analysis feature selection on Diffusion Weighted Imaging for Alzheimer’s Disease Classification, Neurocomputing (2013) Volume 114, 19 August 2013, Pages 132–141</p> <p>Ariadna Besga, Itxaso González-Ortega, Enrique Echeburúa, Alexandre Savio, Borja Ayerdi, Darya Chyzhyk, Jose LM Madrigal, Juan C. Leza, Manuel Graña, Ana González-Pinto, "Discrimination between Alzheimer’s Disease and Late Onset Bipolar Disorder using multivariate analysis" Frontiers in Aging Neuroscience, 7:231</p> <p>Ariadna Besga-Basterra, Darya Chyzhyk, Itxaso González-Ortega, Alexandre Savio, Borja Ayerdi, Jon Echeveste, Manuel Graña, Ana González-Pinto, Eigenanatomy on fractional anisotropy imaging provides white matter anatomical features discriminating between Alzheimer’s Disease and Late Onset Bipolar Disorder, Current Alzheimer Research, 13(5): 557 - 565 (2016)</p> <p>Ariadna Besga, Darya Chyzhyk, Itxaso Gonzalez Ortega, Jon Echeveste, Marina Grana-Lecuona, Manuel Grana, Ana González-Pinto, White Matter Tract Integrity in Alzheimer’s Disease versus Late Onset Bipolar Disorder and its Correlation with Systemic Inflammation and Oxidative Stress Biomarkers, Frontiers in Aging Neuroscience, 9:179 (2017)</p>
A blinded, controlled trial of objective measurement in Parkinson's disease
<p>Medical conditions with effective therapies are usually managed with objective measurement and therapeutic targets. Parkinson's disease has effective therapies, but continuous objective measurement has only recently become available. This blinded, controlled study examined whether management of Parkinson's disease was improved when clinical assessment and therapeutic decisions were aided by objective measurement. The primary endpoint was improvement in the Movement Disorder Society-United Parkinson's Disease Rating Scale's (MDS-UPDRS) Total Score. In one arm, objective measurement assisted doctors to alter therapy over successive visits until objective measurement scores were in target. Patients in the other arm were conventionally assessed and therapies were changed until judged optimal. There were 75 subjects in the objective measurement arm and 79 in the arm with conventional assessment and treatment. There were statistically significant improvements in the moderate clinically meaningful range in the MDS-UPDRS Total, III, IV scales in the arm using objective measurement, but not in the conventionally treated arm. These findings show that global motor and non-motor disability is improved when the management of Parkinson's disease is assisted by objective measurement.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.