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126 results for “disease emergence”
What do studies in wild mammals tell us about human emerging viral diseases in Mexico? database
<p>The database used in the article "<strong>What do studies in wild mammals tell us about human emerging viral diseases in Mexico?</strong>". It contains all available records of viral zoonotic and potential zoonotic species in Mexican wild mammals.</p> <p>The first file is a .csv file and the second one is .xls</p>
Fig. 7. Box plots comparing average counts per 10 in Trypanosomiasis: An emerging disease in Alpine swift (Tachymarptis melba) nestlings in Switzerland?
Fig. 7. Box plots comparing average counts per 10 HPF of granulocytes, mononuclear cells, and thrombocytes between positive (n = 20) and negative (n = 20) 45- day-old Alpine swift nestlings sampled in 2022.
Fig. 5 in Trypanosomiasis: An emerging disease in Alpine swift (Tachymarptis melba) nestlings in Switzerland?
Fig. 5. Skeletal musculature of a nestling Alpine swift showing infiltrations of mononuclear inflammatory cells (A, B) and presumably extracellular, amastigote-like structures (C). Bursa fabricii of a nestling Alpine swift with depletion of the medullary follicle with lymphocytolysis (asterisk) and a distinct epithelium (arrows) (D).
Fig. 6 in Trypanosomiasis: An emerging disease in Alpine swift (Tachymarptis melba) nestlings in Switzerland?
Fig. 6. Blood smears of nestling Alpine swifts with high (A) and moderate (B) trypomastigote burdens. Close-up of a trypomastigote between erythrocytes (C).
Fig. 4 in Trypanosomiasis: An emerging disease in Alpine swift (Tachymarptis melba) nestlings in Switzerland?
Fig. 4. Distribution of louse flies on an Alpine swift nestling (A) compared with the distribution of bruising on post-mortem examination with plumage removed (B).
Fig. 3 in Trypanosomiasis: An emerging disease in Alpine swift (Tachymarptis melba) nestlings in Switzerland?
Fig. 3. Missing (left wing) and poor quality (right wing) primary feathers on a 45-day-old nestling.
Fig. 1 in Trypanosomiasis: An emerging disease in Alpine swift (Tachymarptis melba) nestlings in Switzerland?
Fig. 1. Map of Switzerland with the locations and appearance of the three evaluated colonies (A, B, C).
Fig. 3 in Molecular characterization of the re-emerging West Nile virus in avian species and equids in Israel, 2018, and pathological description of the disease
Fig. 3 Brain histopathology of WNV-infected horses. Perivascular cuffs composed of lymphocytes and plasma cells in the brain of two horses, characteristic of viral encephalitis (marked by arrows). a Horse no. Eq111 (324085). b Horse no. Eq117 (325903). 100× magnification
Fig. 2 in Molecular characterization of the re-emerging West Nile virus in avian species and equids in Israel, 2018, and pathological description of the disease
Fig. 2 Brain histopathology of WNV-infected long-eared owl (Asio otus) AV156. a A glial nodule in the brain stem (marked by an arrow). 100× magnification. b A glial nodule in the brain stem with few adjacent necrotic neurons, 400× magnification
Fig. 1 in Variable changes in nematode infection prevalence and intensity after Rabbit Haemorrhagic Disease Virus emerged in wild rabbits in Scotland and New Zealand
Fig. 1. Differences in mean intensity of nematode parasite infection in rabbits sampled seasonally from New Zealand and Scotland before the spread of RHDV (a), rabbits sampled seasonally from Sotland before and after RHDV (b), and rabbits sampled in autumn season from New Zealand and Scotland before and after RHDV (c). Nematode parasites included T. retortaeformis (i) G. strigosum (ii) and P. ambiguus (iii) found in rabbits sampled in spring (Spr), summer (Sum), autumn (Aut) and winter (Win).
Fig. 4 in Molecular characterization of the re-emerging West Nile virus in avian species and equids in Israel, 2018, and pathological description of the disease
Fig. 4 Replication of yellow-legged seagull-derived WNV in Vero and C6/36 cells. Cytopathic effect (left) was observed after one passage in both cell lines. The control cells (right) were grown under the same conditions. Scale-bars: 100 µM
Fig. 5 in Molecular characterization of the re-emerging West Nile virus in avian species and equids in Israel, 2018, and pathological description of the disease
Fig. 5 Phylogenetic analysis of West Nile viruses (WNVs) from avian and equine hosts studied in Israel during 2016 and 2018. The analysis was conducted on a nucleotide sequence of the genes encoding the capsid, pre-membrane protein, and membrane protein, using the neighbor-joining method implemented in MEGA X software. The robustness of branching pattern was tested by 1000 bootstrap replications. The rates among sites algorithm used was gamma distribution with invariant sites (G+I). The bar denotes 0.02 nucleotide substitutions per site. Lineage 1 and 2 reference strains are present with country and year of isolation. The GenBank annotated sequences are underlined and the sequences obtained in this study (during 2016 and 2018) are marked with rectangles
Spatial transcriptomics stratifies health and psoriatic disease severity by emergent cellular ecosystems
<p>While human inflammatory skin diseases' cellular and molecular features are well-characterized, their tissue context and systemic impact remain poorly understood. We thus profiled human psoriasis (PsO) as a prototypic immune-mediated condition with a high preference for extra-cutaneous involvement. Spatial transcriptomics (ST) analyses of 25 healthy, active, and clinically uninvolved skin biopsies, and integration with public single-cell transcriptomics data revealed striking differences in immune microniches between healthy and inflamed skin. Tissue scale-cartography further identified core disease features across all active lesions, including the emergence of an inflamed suprabasal epidermal state and the presence of B lymphocytes in lesional skin. Notably, both lesional and distal non-lesional samples were stratified by skin disease severity, and not by the presence of systemic disease. This segregation was driven by macrophage-, fibroblast- and lymphatic-enriched spatial regions with gene signatures associated with metabolic dysfunction. Taken together, these findings suggest that mild and severe forms of PsO have distinct molecular features and that severe PsO may profoundly alter the cellular and metabolic make up of distal unaffected skin sites. Additionally, our study provides an unprecedented resource for the research community to study spatial gene organization of healthy and inflamed human skin. </p>
Indirect pathogen transmission underlies an emerging infectious fungal disease outbreak in a wild reptile population
Open the record for dataset details and reuse information.
Fig. 2 in Trypanosomiasis: An emerging disease in Alpine swift (Tachymarptis melba) nestlings in Switzerland?
Fig. 2. Fledging indexes of 7 Swiss Alpine swift colonies from 2015 to 2022.
Fig. 1 in Molecular characterization of the re-emerging West Nile virus in avian species and equids in Israel, 2018, and pathological description of the disease
Fig. 1 Meningeal and brain tissue hemorrhages in WNV-infected long eared owl (Asio otus) AV156
Emergent Ecological Patterns and Modelling of Gut Microbiomes in Health and in Disease
<p><strong><em>Data associated with the paper "Emergent Ecological Patterns and Modelling of Gut Microbiomes in Health and in Disease".</em></strong></p> <p><strong>Content:</strong></p> <ul> <li><strong>Metagenomic curated data considering healthy and diseased state of the human individuals. Aligned against RefSeq with Kaiju.</strong></li> <li><strong>Curated metadata with anonymised physiological and medical information</strong></li> </ul> <p><strong>Paper authors</strong>: Jacopo Pasqualini, Sonia Facchin, Andrea Rinaldo, Amos Maritan, Edoardo Vincenzo Savarino, Samir Suweis</p> <p><strong>Paper preprint</strong>: https://www.biorxiv.org/content/10.1101/2023.10.19.563037v2</p> <p><strong>Data Curator</strong>: Jacopo Pasqualini.</p> <p><strong>Pipeline used to generate the data</strong>: https://github.com/jacopopasqualini/MetaGym</p> <p><strong>Complete description of data generation</strong>: https://www.biorxiv.org/content/10.1101/2023.10.19.563037v2</p>
Table 2 in Molecular characterization of the re-emerging West Nile virus in avian species and equids in Israel, 2018, and pathological description of the disease
<p><b>Table 2</b> Pathological findings and calculated viral genome copies of WNV-positive avian species</p><table><thead><tr><th>Bird no.</th><th>Species</th><th>Common name</th><th>Sequencing</th><th>Isolation</th><th>Tissues tested and calculated target copies per reaction</th></tr></thead><tbody><tr><th>AV148</th><td><i>Larus michahellis</i></td><td>Yellow legged seagull</td><td>Yes</td><td>Yes</td><td>Cloacal swab: 5.8×10 6; brain: 2.8×10 6; kidney: 1.2×10 7</td></tr><tr><th>AV152</th><td><i>Anser anser</i></td><td>Domesticated goose</td><td>Yes</td><td>Yes</td><td>Cloacal swab:9.7×10 5; brain 3.3× 10 5; kidney: 4700; eye swab: 1.3× 10 6</td></tr><tr><th>AV153</th><td><i>Anser anser</i></td><td>Domesticated goose</td><td>Yes</td><td>Yes</td><td>Cloacal swab: 6.8×10 5; brain: 1.2×10 7; viscera: 6.8× 10 5</td></tr><tr><th>AV156</th><td><i>Asio otus</i></td><td>Long eared owl</td><td>Yes</td><td>No</td><td>Cloacal swab: 6.8×10 5; brain: 2.6×10 4; viscera: 4.9× 10 7</td></tr><tr><th>AV157</th><td><i>Asio otus</i></td><td>Long eared owl</td><td>Yes</td><td>No</td><td>Cloacal swab: 6.8×10 5; brain: 5800; kidney: 360; eye swab: 50</td></tr><tr><th>AV169</th><td><i>Corvus cornix</i></td><td>Hooded crow</td><td>Yes</td><td>No</td><td>Cloacal swab: 4700; blood: 1100</td></tr><tr><th>AV178</th><td><i>Phasianus colchicus</i></td><td>Common pheasant</td><td>No</td><td>No</td><td>Brain: 4700</td></tr><tr><th>1459</th><td><i>Corvus cornix</i></td><td>Hooded crow</td><td>Yes</td><td>No</td><td>Cloacal swab: 2300</td></tr><tr><th>1505</th><td><i>Corvus cornix</i></td><td>Hooded crow</td><td>Yes</td><td>No</td><td>Brain: 4700</td></tr><tr><th>1514</th><td><i>Corvus cornix</i></td><td>Hooded crow</td><td>Yes</td><td>Yes</td><td>Brain: 9.9× 10 7</td></tr></tbody></table>
Table 1 in Molecular characterization of the re-emerging West Nile virus in avian species and equids in Israel, 2018, and pathological description of the disease
<p><b>Table 1</b> Details of the examined WNV-positive avian species</p><table><thead><tr><th>Bird no.</th><th>Species</th><th>Date</th><th>Neurological signs</th><th>Intracranial haemorrhages</th><th>Location</th><th>Comments</th></tr></thead><tbody><tr><th>AV148</th><td><i>Larus michahellis</i>, yellow legged seagull</td><td>18 July 2018</td><td>Unknown</td><td>+</td><td>Tel-Aviv</td><td>Found dead</td></tr><tr><th>AV152</th><td><i>Anser anser domesticus</i>, domesticated goose</td><td>18 July 2018</td><td>+</td><td>+</td><td>Burgata a</td><td>Found dead in petting zoo</td></tr><tr><th>AV153</th><td><i>Anser anser domesticus</i>, domesticated goose</td><td>18 July 2018</td><td>Unknown</td><td>+</td><td>Burgata a</td><td>Found dead in petting zoo</td></tr><tr><th>AV156</th><td><i>Asio otus</i>, long eared owl</td><td>18 July 2018</td><td>Unknown</td><td>+</td><td>Hadid</td><td>Hospitalized and died</td></tr><tr><th>AV157</th><td><i>Asio otus</i>, long eared owl</td><td>18 July 2018</td><td>Unknown</td><td>+</td><td>Ramat Razi’el</td><td>Found dead</td></tr><tr><th>AV169</th><td><i>Corvus cornix</i>, hooded crow</td><td>18 August 2018</td><td>+</td><td>Unknown</td><td>Rishon Letzion</td><td>Found neurological and died within 24 h</td></tr><tr><th>AV178</th><td><i>Phasianus colchicus</i>, common pheasant</td><td>18 August 2018</td><td>Unknown</td><td>+</td><td>Burgata a</td><td>Found dead in petting zoo</td></tr><tr><th>1459</th><td><i>Corvus cornix</i>, hooded crow</td><td>18 October 2018</td><td>−</td><td>Unknown</td><td>Tel-Aviv</td><td>Healthy bird in quarantine</td></tr><tr><th>1505</th><td><i>Corvus cornix</i>, hooded crow</td><td>18 October 2018</td><td>Unknown</td><td>+</td><td>Tel-Aviv</td><td>Found dead</td></tr><tr><th>1514</th><td><i>Corvus cornix</i>, hooded crow</td><td>18 October 2018</td><td>+</td><td>Unknown</td><td>Tel-Aviv</td><td>Found sick, died in hospital</td></tr></tbody></table><p><sup>a</sup> Same petting zoo</p><p><i>KEy</i>: +, characteristic WNF neurological signs observed;−, no characteristic WNF neurological signs observed</p>
Table 3 in Molecular characterization of the re-emerging West Nile virus in avian species and equids in Israel, 2018, and pathological description of the disease
<p><b>Table 3</b> Details and calculated viral genome copies of WNF-positive equids</p><table><thead><tr><th>Animal no.</th><th>Species</th><th>Date</th><th>Location</th><th>Tissues tested and calculated target copies per reaction</th><th>Comments</th></tr></thead><tbody><tr><th>Eq111 324085</th><td>Horse 1 (2-years-old)</td><td>18 June 2018</td><td>Kfar Shmu’el</td><td>Spleen: negative; brain: 2290</td><td>Euthanized</td></tr><tr><th>Eq115 325209</th><td>Donkey 1 (30-years-old)</td><td>18 July 2018</td><td>Gan Yoshyia</td><td>Brain: 550; spinal cord, CSF,spleen: all negative</td><td>Euthanized</td></tr><tr><th>Eq117 325903</th><td>Horse 2 (11-years-old)</td><td>18 July 2018</td><td>Kfar Truman</td><td>Cerebellum: 550; medulla: 4670; cervical spinal cord: 1990; thoracic spinal cord: 310;lumbar spinal cord: 680; spleen: negative; serum: negative</td><td>Euthanized</td></tr><tr><th>Eq142 333326</th><td>Horse 3 (20- years-old)</td><td>18 October 2018</td><td>Kfar Sirkin</td><td>NS2A probe: cerebellum: 4000; medulla: 56,400</td><td>Euthanized</td></tr></tbody></table>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.