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ShareScore release 0.9.0
Dataset results
29 results for “disease resilience”
Data from: Pathways underlying selective neuronal vulnerability in Alzheimer's disease: Contrasting the vulnerable locus coeruleus to the resilient substantia nigra
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Assessing and Promoting Resilience in Patients With Adult Congenital Heart Disease
ClinicalTrials.gov study NCT04738474. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Devastating disease can cause increased breeding effort and success that improves population resilience
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Measuring resilience and resistance in aging and Alzheimer disease using residual methods: A systematic review and meta-analysis
<p>Objective: There is currently a lack of consensus on how to optimally define and measure resistance and resilience in brain and cognitive aging. Residual methods use residuals from regression analysis to quantify the capacity to avoid (resistance) or cope (resilience) "better or worse than expected" given a certain level of risk or cerebral damage. We reviewed the rapidly-growing literature on residual methods in the context of aging and Alzheimer's disease (AD), and performed meta-analyses to investigate associations of residual-method based resilience and resistance measures with longitudinal cognitive and clinical outcomes.</p> <p>Methods: A systematic literature search of PubMed and Web-of-Science databases (consulted until March 2020) and subsequent screening led to 54 studies fulfilling eligibility criteria, including 10 studies suitable for the meta-analyses.</p> <p>Results: We identified articles using residual methods aimed at quantifying resistance (n=33), cognitive resilience (n=23) and brain resilience (n=2). Critical examination of the literature revealed that there is considerable methodological variability in how the residual measures were derived and validated. Despite methodological differences across studies, meta-analytic assessments showed significant associations of levels of resistance (HR[95%CI]=1.12[1.07-1.17], p<0.0001) and levels of resilience (HR[95%CI]=0.46[0.32-0.68], p<0.001) with risk of progression to dementia/AD. Resilience was also associated with rate of cognitive decline (β[95%CI]=0.05[0.01-0.08], p<0.01).</p> <p>Conclusion: This review and meta-analysis supports the usefulness of residual methods as appropriate measures of resilience and resistance, as they capture clinically meaningful information in aging and AD. More rigorous methodological standardization is needed, however, to increase comparability across studies and, ultimately, application in clinical practice.</p>
Psychological Trauma, Post-Traumatic Stress Disorder, and Resilience in Adults With Congenital Heart Disease
ClinicalTrials.gov study NCT06952933. IPD Sharing: NO. Countries: 1. Publications: 4.
Characterising Physiological Resilience in People With Parkinson's Disease
ClinicalTrials.gov study NCT07013513. IPD Sharing: NO. Countries: 1. Publications: 23.
Pulmonary Disease Requiring Ambulatory Oxygen Therapy -Resilience and Quality of Life
ClinicalTrials.gov study NCT04554225. IPD Sharing: NO. Countries: 1. Publications: 2.
Measuring resilience and resistance in aging and Alzheimer disease using residual methods: A systematic review and meta-analysis
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Promoting Stress Management and Resilience Among Individuals With Von Hippel- Lindau Disease
ClinicalTrials.gov study NCT05737602. IPD Sharing: YES. Countries: 1. Publications: 0.
ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimer's disease through BDNF/NGFR signaling
GEO Series GSE244550. Danio rerio. 4 samples. Type: Expression profiling by high throughput sequencing.
Identifying main functional pathways associated with cognitive resilience to Alzheimer ´s Disease
GEO Series GSE180968. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Gene-expression profiling of individuals resilient to Alzheimer's disease reveals higher expression of genes related to metallothionein and mitochondrial processes and no changes in the unfolded prote
GEO Series GSE261817. Homo sapiens. 35 samples. Type: Expression profiling by high throughput sequencing.
Resilience to Endoplasmic Reticulum Stress Mitigates Calcium-Dependent Membrane Hyperexcitability Underlying Late Disease Onset in Spinocerebellar Ataxia Type 6
GEO Series GSE264100. Mus musculus. 40 samples. Type: Expression profiling by high throughput sequencing.
Tracking resilience to infections by mapping disease space
GEO Series GSE61191. Mus musculus. 128 samples. Type: Expression profiling by array.
Pathways underlying selective neuronal vulnerability in Alzheimer's disease: contrasting the vulnerable locus coeruleus to the resilient substantia nigra
GEO Series GSE273787. Homo sapiens. 44 samples. Type: Expression profiling by high throughput sequencing.
Integrating Metabolism, Connectivity, and Mesoscale Imaging at Ultra-high Field to Decipher Mechanisms of Resilience and Neurodegeneration in Neurological Diseases and Healthy Aging
ClinicalTrials.gov study NCT07202494. IPD Sharing: NO. Countries: 1. Publications: 0.
Stress Management and Resiliency Training Program for Parkinson's Disease
ClinicalTrials.gov study NCT04903769. IPD Sharing: NO. Countries: 1. Publications: 0.
Promoting Resilience Among Adolescents and Young Adults With Sickle Cell Disease
ClinicalTrials.gov study NCT06555939. IPD Sharing: YES. Countries: 1. Publications: 0.
Self-management Behaviors and Resilience Among Chronic Obstructive Pulmonary Disease Patients
ClinicalTrials.gov study NCT05459740. IPD Sharing: NO. Countries: 1. Publications: 0.
Resilience and Coping in a Rare Skeletal Disease Population to Face Coronavirus (COVID-19) Outbreak Distress: a Longitudinal Study
ClinicalTrials.gov study NCT04844697. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.