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3 results for “dissolution profiles”
Quantifying Dissolution Dynamics in Porous Media Using a Spatial Flow Focusing Profile
<p>The diverse range of patterns in porous media formed by dissolution processes depends on the relative magnitude of flow, transport, and chemical reactions at pore surfaces. However, distinguishing between regimes often relies solely on qualitative, visual comparisons of emergent structures. Here, we propose a quantitative measure capable of identifying different regimes using the concept of the spatial flow focusing profile, which segments the medium into cross sections along the flow direction to calculate the flow focusing index for each section. We employ this measure in numerical simulations of a dissolving porous medium using a pore-network model. We obtain a morphological phase diagram of dissolution patterns, which we characterize using the flow focusing profile. In particular, we demonstrate that analyzing the temporal changes in the profile allows one to quantitatively distinguish between wormholing and channeling. The transition between them is shown to be affected by the heterogeneity of the system.</p>
Dataset for Formulation of minitablets with personalised dissolution profile by fluid-bed granulation of drug nanosuspensions
<p>Source data for all graphs in the manuscript titled "Formulation of minitablets with personalised dissolution profile by fluid-bed granulation of drug nanosuspensions" by Mutylo et al., submitted to International Journal of Pharmaceutics. The data sets contains values for particle size distributions, tablet uniformity, drug loading, and dissolution curves.</p>
A Study to Assess the Effects of Dissolution Profile on the Pharmacokinetics of Single Oral Doses of Tafenoquine Tablets and Tafenoquine Stable Isotope Labelled Solution
ClinicalTrials.gov study NCT02751294. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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