Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
56
datasets available to search
ShareScore release 0.9.0
Dataset results
56 results for “dna-seq”
Targeted DNA-seq analysis was performed on sorted population of CD45+/CD34+ HSPCs from control or FLI-1 modified mRNA treated mPB after co-culture with vascular niche cells
<p>Human mPB HSPCs were harvested isolated and transduced with either control or FLI-1 modified mRNA. HSPCs were introduced into co-culture with vascular niche ECs. Cultures were harvested and CD45+/CD34+ HSPCs were resoerted and processed for trageted DNA-seq analysis. Contains raw FASTQ sequencing files, unfiltered VCFs, and curated results in an excel.</p>
Long-read DNA-Seq of SmAP1 knockout strains
<p>Halobacterium salinarum knockout strains (delta-Ura3: control; delta-Ura3/delta-SmAP1: SmAP1 knockout) were cultured in uracil-supplemented (50 μg/mL) complex medium (CM) until mid-exponential phase (OD600nm = 0.5). The cultures were grown at 37C, under light exposure, and with constant agitation (125 RPM). We collected 2 mL samples and submitted them to DNA extraction using the DNeasy Blood & Tissue kit (QIAGEN), according to the manufacturer's instructions for Gram-negative bacteria. We tested DNA samples for purity and quantity using spectrophotometric and fluorimetric methods, respectively. The samples were prepared for long-read sequencing following the 1D native barcoding genomic DNA protocol using SQK-LSK108 and EXP-NBD103 (Oxford Nanopore Technologies). The equimolar pool of barcoded samples was sequenced using a MinION Mk1B instrument (Oxford Nanopore Technologies) in an FLO-MIN106 flow cell for 24 hours. Three biological replicates were sequenced for each one of the strains (control and SmAP1 knockout). This repository stores the partitioned (eleven parts: aa-ak) compressed directory (tar.gz) containing all the raw reads (fast5 format) output by the MinKNOW software.</p> <p><strong>Experimental design:</strong></p> <table> <tbody> <tr> <td><strong>Barcode</strong></td> <td><strong>Description</strong></td> </tr> <tr> <td>Barcode 01</td> <td>Control, biological replicate 1</td> </tr> <tr> <td>Barcode 02</td> <td>Control, biological replicate 2</td> </tr> <tr> <td>Barcode 03</td> <td>Control, biological replicate 3</td> </tr> <tr> <td>Barcode 04</td> <td>SmAP1 knockout, biological replicate 1</td> </tr> <tr> <td>Barcode 05</td> <td>SmAP1 knockout, biological replicate 2</td> </tr> <tr> <td>Barcode 06</td> <td>SmAP1 knockout, biological replicate 3</td> </tr> </tbody> </table> <p><strong>Instructions to merge files and extract:</strong></p> <p>1. Download all the files available in this Zenodo entry (smap1_ko_exp_fast5.tar.gz.part_a*; from aa to ak; eleven files) to your preferred directory;</p> <p>2. Execute the following commands using a Linux or OSX terminal:</p> <pre><code class="language-bash"># concatenate all the files into a single one cat smap1_ko_exp_fast5.tar.gz.part_a* > smap1_ko_exp_fast5.tar.gz # extract the merged file tar zxvf smap1_ko_exp_fast5.tar.gz</code></pre> <p> </p>
Mapping functional to morphological variation reveals the basis of regional extracellular matrix subversion and nerve invasion in pancreatic cancer [DNA-seq]
GEO Series GSE209951. Homo sapiens. 52 samples. Type: Other.
Disruption of deoxynucleotide biosynthesis leads to RASproto-oncogene activation and perturbation of mitochondrial metabolism [DNA-seq]
GEO Series GSE261896. Homo sapiens. 24 samples. Type: Other.
Integrating Next Generation Sequencing with Morphology Improves Prognostic and Biologic Classification of Spitz Neoplasms [DNA-Seq]
GEO Series GSE142442. Homo sapiens. 158 samples. Type: Genome variation profiling by high throughput sequencing.
CRISPR-Cas9-based editing of histone H3 arginine 17 reveals its methylation-dependent regulation of Yap signaling and early mouse embryo development (genomic DNA-seq data set)
GEO Series GSE112539. Mus musculus. 8 samples. Type: Other.
Somatic piRNA pathway prevents transgenerational germline transposition [DNA-seq]
GEO Series GSE112925. Drosophila melanogaster. 14 samples. Type: Other.
Hierarchical Lineage Tracing Reveals Diverse Pathways of AML Treatment Resistance [DNA-seq]
GEO Series GSE289459. Mus musculus. 22 samples. Type: Other.
Role of the SAF-A SAP domain in X inactivation, transcription, splicing, and cell proliferation [DNA-seq]
GEO Series GSE277219. Homo sapiens. 1 samples. Type: Genome variation profiling by high throughput sequencing.
Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations [bulk DNA-Seq]
GEO Series GSE229781. Mus musculus. 10 samples. Type: Other.
The functional enhancer repertoire of human embryonic stem cells [isolated plasmid DNA-seq]
GEO Series GSE99628. Homo sapiens. 10 samples. Type: Other.
DDX3X suppresses neural lineage susceptibility to medulloblastoma [DNA-Seq]
GEO Series GSE147069. Mus musculus. 13 samples. Type: Genome variation profiling by high throughput sequencing.
The functional enhancer repertoire of human embryonic stem cells [plasmid DNA-seq]
GEO Series GSE99629. Homo sapiens. 12 samples. Type: Other.
Histone acetyltransferase p300 induces de novo super-enhancers to drive cellular senescence [DNA-seq]
GEO Series GSE105935. Homo sapiens. 50 samples. Type: Other.
RNA-seq. and DNA-seq. of Pseudomonas aeruginosa PAO1 derived membrane vesicles
GEO Series GSE63388. Pseudomonas aeruginosa PAO1. 3 samples. Type: Expression profiling by high throughput sequencing.
Loss of TET2 results in gene expression represssion in mouse naïve B-cells and lymphoma cells [DNA-Seq]
GEO Series GSE140085. Mus musculus. 5 samples. Type: Other.
The role of ATXR6 expression in modulating genome stability and transposable element repression in Arabidopsis [DNA-seq]
GEO Series GSE166882. Arabidopsis thaliana. 3 samples. Type: Other.
Plasma Multi-omics Nucleic Acid Landscape of Gastrointestinal Cancer [DNA-seq]
GEO Series GSE186573. Homo sapiens. 86 samples. Type: Other.
Fat1 deletion promotes hybrid EMT state with enhanced tumor progression, stemness, and metastasis (DNA-Seq)
GEO Series GSE158505. Homo sapiens. 16 samples. Type: Other.
DNA-seq in male ES cells cultured by either standard ES cell culture or our improved culture conditions [Male DNA-seq]
GEO Series GSE137158. Mus musculus. 10 samples. Type: Other.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.