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ShareScore release 0.9.0
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7 results for “dormant origins”
Data from: The replication of Frataxin gene is assured by activation of dormant origins in the presence of a GAA-repeat expansion
It is well known that DNA replication affects the stability of several trinucleotide repeats, but whether replication profiles of human loci carrying an expanded repeat differ from those of normal alleles is poorly understood in the endogenous context. We investigated this issue using cell lines from Friedreich's ataxia patients, homozygous for a GAA-repeat expansion in intron 1 of the Frataxin gene. By interphase, FISH we found that in comparison to the normal Frataxin sequence the replication of expanded alleles is slowed or delayed. According to molecular combing, origins never fired within the normal Frataxin allele. In contrast, in mutant alleles dormant origins are recruited within the gene, causing a switch of the prevalent fork direction through the expanded repeat. Furthermore, a global modification of the replication profile, involving origin choice and a differential distribution of unidirectional forks, was observed in the surrounding 850 kb region. These data provide a wide-view of the interplay of events occurring during replication of genes carrying an expanded repeat.
Data from: The replication of Frataxin gene is assured by activation of dormant origins in the presence of a GAA-repeat expansion
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BRCA2 suppresses “head-on” transcription-replication conflicts incurred by dormant origin firing at transcription termination sites [RNA-seq]
GEO Series GSE239857. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
BRCA2 suppresses “head-on” transcription-replication conflicts incurred by dormant origin firing at transcription termination sites [Ok-seq]
GEO Series GSE239856. Homo sapiens. 6 samples. Type: Other.
BRCA2 suppresses “head-on” transcription-replication conflicts incurred by dormant origin firing at transcription termination sites
GEO Series GSE239858. Homo sapiens. 14 samples. Type: Other; Expression profiling by high throughput sequencing.
Selective interactions at pre-replication complexes categorize baseline and dormant origins
GEO Series GSE276856. Homo sapiens. 211 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other.
Dormant origins and fork protection mechanisms rescue sister forks arrested by transcription
GEO Series GSE97046. Saccharomyces cerevisiae. 6 samples. Type: Genome binding/occupancy profiling by genome tiling array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.