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9 results for “doublecortin”
Doublecortin and JIP3 are neural-specific counteracting regulators of dynein-mediated retrograde trafficking
Mutations in the microtubule (MT)-binding protein doublecortin (DCX) or in the MT-based molecular motor dynein result in lissencephaly. However, a functional link between DCX and dynein has not been defined. Here, we demonstrate that DCX negatively regulates dynein-mediated retrograde transport by reducing dynein's association with MTs and by disrupting the composition of the dynein motor complex. Previous work showed an increased binding of the adaptor protein C-Jun-amino-terminal kinase-interacting protein 3 (JIP3) to dynein in the absence of DCX. Using purified components, we demonstrate that JIP3 forms an active motor complex with dynein and its cofactor dynactin with two dyneins per complex. DCX competes with the binding of the second dynein, resulting in a velocity reduction of the complex. We conclude that DCX negatively regulates dynein-mediated retrograde transport through two critical interactions by regulating dynein binding to MTs and by regulating the association of JIP3 to the dynein motor complex.
Data for: Doublecortin reinforces microtubules to promote growth cone advance in soft environments
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Doublecortin and JIP3 are neural-specific counteracting regulators of dynein-mediated retrograde trafficking
Open the record for dataset details and reuse information.
Tumor necrosis factor promotes doublecortin-like kinase 1 expression and cellular reprogramming in intestinal epithelial cells leading to neoplastic transformation
GEO Series GSE279531. Rattus norvegicus. 2 samples. Type: Expression profiling by high throughput sequencing.
Discovery of a selective inhibitor of Doublecortin Like Kinase 1
GEO Series GSE140490. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Early born neurons are abnormally positioned in the doublecortin knockout hippocampus
GEO Series GSE87019. Mus musculus. 15 samples. Type: Expression profiling by array.
Targeting doublecortin-like kinase 1 reveals a novel strategy to circumvent chemoresistance and metastasis in ovarian cancer
GEO Series GSE245347. Homo sapiens. 6 samples. Type: Expression profiling by array.
Doublecortin mutation leads to persistent defects in the Golgi apparatus and mitochondria in adult hippocampal pyramidal cells
GEO Series GSE185031. Mus musculus. 14 samples. Type: Expression profiling by array.
Doublecortin-like kinase 1 activates NF-κB to induce inflammatory responses by binding directly to IKKβ
GEO Series GSE224030. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.