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298 results for “doxycycline”
Data from: Transgenerational effects of doxycycline and anhydrotetracycline on the microbiome of the Australian sheep blowfly, Lucilia cuprina
<p>Tetracyclines are a family of broad-spectrum antibiotics commonly used in agriculture, medicine, and research. However, exposure to tetracyclines is associated with a wide range of negative health outcomes. In some cases, these negative effects are transgenerational: when individuals are treated with tetracyclines, their untreated offspring exhibit phenotypic abnormalities. The causes of such transgenerational effects are not well-understood, but disruption of the microbiome and/or mitochondria may play an important role. Transgenerational effects from tetracyclines may threaten the success of an environmentally-friendly form of pest control, the release of transgenic males carrying a tetracycline-repressible female lethal gene. In this study, we investigated the direct and transgenerational effects of two tetracycline-class antibiotics, doxycycline (DOX) and anhydrotetracycline (ATC), on the blowfly<em> Lucilia cuprina</em>, a facultative parasite of sheep. To simulate the rearing conditions used in a male-only release program, blowflies were reared on diet alone, or diet plus DOX or ATC, for three generations, then reared for an additional fourth generation off tetracyclines. We used 16S amplicon sequencing and qPCR to examine whole-body microbiome composition and bacterial and mitochondrial DNA abundance in third and fourth generation flies. The microbiomes of third generation flies reared on DOX or ATC were similar in composition and diversity to the microbiomes of flies reared exclusively on the control diet. However, we found that the untreated fourth generation offspring of DOX- or ATC-treated flies displayed major shifts in microbiome composition relative to both their treated parents and untreated control groups. Our study supports a growing body of evidence that tetracyclines exert both direct and transgenerational effects on arthropods, and highlights the need to address these impacts in the context of insect pest management.</p>
Statistical analysis of data determining minimal selective concentration of Amoxicillin, doxycycline and enrofloxacin
<p>This repository is containing the datasets with statistical analysis of the paper: "Selection for amoxicillin, doxycycline and enrofloxacin resistant Escherichia coli at concentrations lower tha nthe ECOFF in rich media and in broiler-derived fecal fermenations."</p> <p><em>The phenotypic analysis</em></p> <ul> <li>Phenotypic amoxicillin <ul> <li>R-file: Phenotypic Amox mixed models, CSV-file: Phenotypic data Amox</li> </ul> </li> <li>Phenotypic doxycycline <ul> <li>R-file: Phenotypic Dox mixed models, CSV-file: Phenotypic data Dox</li> </ul> </li> <li>Phenotypic enrofloxacin <ul> <li>R-file: Phenotypic Enro mixed models, CSV-file: Phenotypic data Enro</li> </ul> </li> </ul> <p><em>The resistome analysis </em></p> <ul> <li>two CSV-files: Resistoom workfile and resistome_reference_file</li> <li>one R-file: Resistome_analysis_antimicrobial_classes</li> </ul> <p><em>Microbiome analysis<br></em></p> <ul> <li>Alpha- and beta-diversity analysis<br> <ul> <li>R-file Biom analysis, CSV-file: metadata2, biom-file: reads_fermentation</li> </ul> </li> <li>Microbial abundance analysis <ul> <li>R-file: Abundance plot, CSV-file: metadata2. biom-file: reads_fermentation2.biom</li> </ul> </li> </ul>
Protection of the Heart With Doxycycline During Coronary Artery Bypass Grafting
ClinicalTrials.gov study NCT00246740. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Doxycycline Treatment to Prevent Progressive Coronary Artery Dilation in Children With Kawasaki Disease
ClinicalTrials.gov study NCT01917721. IPD Sharing: NO. Countries: 1. Publications: 1.
NGU: Doxycycline (Plus or Minus Tinidazole) Versus Azithromycin (Plus or Minus Tinidazole)
ClinicalTrials.gov study NCT00322465. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Evaluation of Doxycycline Verses Placebo for the Treatment of Severe Nonproliferative or Mild or Moderate Proliferative Diabetic Retinopathy
ClinicalTrials.gov study NCT00511875. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users and HIV-infected Men Who Have Sex With Men
ClinicalTrials.gov study NCT03980223. IPD Sharing: NO. Countries: 1. Publications: 13.
Evaluation of Effect of Doxycycline Verses Placebo on Retinal Function and Diabetic Retinopathy
ClinicalTrials.gov study NCT00917553. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Efficacy of Doxycycline Post Exposure Prophylaxis for Preventing STIs Among MSM in Bangkok, Thailand.
ClinicalTrials.gov study NCT07397403. IPD Sharing: NO. Countries: 1. Publications: 12.
Daily Doxycycline to Inform Sexually Transmitted Infection Prophylaxis Regimens
ClinicalTrials.gov study NCT06545656. IPD Sharing: YES. Countries: 1. Publications: 0.
Clinical Trial of Ivermectin Plus Doxycycline for the Treatment of Confirmed Covid-19 Infection
ClinicalTrials.gov study NCT04523831. IPD Sharing: YES. Countries: 1. Publications: 1.
Effect of Postsurgical Systemic Doxycycline After Regenerative Periodontal Therapy
ClinicalTrials.gov study NCT01030666. IPD Sharing: NO. Countries: 1. Publications: 2.
Trial of Doxycycline to Reduce Sputum MMP-9 Activity in Adult Cystic Fibrosis (CF) Patients
ClinicalTrials.gov study NCT01112059. IPD Sharing: NO. Countries: 1. Publications: 1.
Safety and Efficacy Study of Doxycycline in Combination With Interferon-B-1a to Treat Multiple Sclerosis
ClinicalTrials.gov study NCT00246324. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Intra-articular Doxycycline: A Novel Treatment of Adhesive Capsulitis
ClinicalTrials.gov study NCT03479502. IPD Sharing: UNDECIDED. Countries: 1. Publications: 16.
A Study of Continuous Oral Contraceptives and Doxycycline
ClinicalTrials.gov study NCT00480532. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Trial of Azithromycin vs. Doxycycline for the Treatment of Rectal Chlamydia in MSM
ClinicalTrials.gov study NCT03608774. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Doxycycline PEP for Prevention of Sexually Transmitted Infections Among Kenyan Women Using HIV PrEP
ClinicalTrials.gov study NCT04050540. IPD Sharing: NO. Countries: 1. Publications: 3.
Safety and Effect of Doxycycline in Patients With Amyloidosis
ClinicalTrials.gov study NCT01677286. IPD Sharing: UNDECIDED. Countries: 1. Publications: 7.
Efficacy & Safety Comparison of Epiduo With Doxycycline Versus Vehicle With Isotretinoin in the Treatment of Severe Acne
ClinicalTrials.gov study NCT01474590. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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