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31 results for “early life adversity”
The behavioral phenotype of early life adversity
<p>In this dataset, we categorized studies investigating the effects of early life adversity on behavior in mice and rats. The dataset is ideal for meta-analyses. For more information about the dataset and the project, see https://osf.io/ra947/</p>
Early life adversity has sex-dependent effects on survival across the lifespan in rhesus macaques
<p>Data for: Early life adversity has sex-dependent effects on survival across the lifespan in rhesus macaques</p> <p>Patterson, S.K., Andonov, E., Arre, A.M., Martinez, M.I., Negron-Del Valle, J.E., Petersen, R.M, Phillips, D., Rahman, A., Ruiz-Lambides, A., Villanueva, I., Lea, A.J., Snyder-Mackler, N., Brent, L.J., Higham, J.P. "Early life adversity has sex-dependent effects on survival across the lifespan in rhesus macaques." 2024. <em>Philosophical Transactions B. </em></p> <p> </p>
The many faces of early life adversity - Content overlap in validated assessment instruments as well as in fear and reward learning research
<p>The precise assessment of childhood adversity is crucial for understanding the impact of aversive events on mental and physical development. However, the plethora of assessment tools currently used in the literature with unknown overlap in childhood adversity types covered hamper comparability and cumulative knowledge generation. In this study, we conducted two separate item-level content analyses of in total 35 questionnaires aiming to assess childhood adversity. These include 13 questionnaires that were recently recommended based on strong psychometric properties as well as additional 25 questionnaires that were identified through a systematic literature search. The latter provides important insights into the actual use of childhood adversity questionnaires in a specific, exemplary research field (i.e., the association between childhood adversity and threat and reward learning). Of note, only 3 of the recommended questionnaires were employed in this research field. Both item-wise content analysis illustrate substantial heterogeneity in the adversity types assessed across these questionnaires and hence highlight limited overlap in content (i.e., adversity types) covered by different questionnaires. Furthermore, we observed considerable differences in structural properties across all included questionnaires such as the number of items, age ranges assessed as well as the specific response formats (e.g., binary vs. continuous assessments, self vs. caregiver). We discuss implications for the interpretation, comparability and integration of the results from the existing literature and derive specific recommendations for future research. In sum, the substantial heterogeneity in the assessment and operationalization of childhood adversity emphasizes the urgent need for theoretical and methodological solutions to promote comparability, replicability of childhood adversity assessment and foster cumulative knowledge generation in research on the association of childhood adversity and physical as well as psychological health.</p>
Data from: Differential effects of early life adversity on male and female rhesus macaque lifespan
<p>Early life adversity predicts shorter adult lifespan in several animal taxa. Yet, work on long-lived primate populations suggests the evolution of mechanisms that contribute to resiliency and long lives despite early life insults. Here, we tested associations between individual and cumulative early life adversity and lifespan on rhesus macaques at the Cayo Santiago Biological Field Station using 50 years of demographic data. We performed sex-specific survival analyses at different life stages to contrast short-term effects of adversity (i.e., infant survival) with long-term effects (i.e., adult survival). Female infants showed vulnerability to multiple adversities at birth, but affected females who survived to adulthood experienced a reduced risk later in life. In contrast, male infants showed vulnerability to a lower number of adversities at birth, but those who survived to adulthood were negatively affected by both early life individual and cumulative adversity. Our study shows profound immediate effects of insults at birth on female infant cohorts and suggests that affected female adults are more robust. In contrast, adult males who experienced harsh conditions early in life showed an increased mortality risk at older ages as expected from hypotheses within the life course perspective. Our analysis suggests sex-specific selection pressures on life histories and highlights the need for studies addressing the effects of early life adversity across multiple life stages.</p>
Data from: Differential effects of early life adversity on male and female rhesus macaque lifespan
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Accelerated reproduction is not an adaptive response to early life adversity in wild baboons
<p><span><span><span><span><span><span><span><span><span><span><span>In humans and other long-lived species, harsh conditions in early life often lead to profound differences in adult life expectancy. In response, natural selection is expected to accelerate the timing and pace of reproduction in individuals who experience some forms of early life adversity. However, the adaptive benefits of reproductive acceleration following early adversity remain untested. Here we test a recent version of this theory, the internal predictive adaptive response (iPAR) model, by assessing for the first time whether accelerating reproduction following early life adversity leads to higher lifetime reproductive success. We do so by leveraging 48 years of continuous, individual-based data from wild female baboons in the Amboseli ecosystem in Kenya, including prospective, longitudinal data on early life adversity, reproductive pace, and lifetime reproductive success.We find that while adversity in early life led to dramatically shorter lifespans, individuals who experiencedearly adversity didnot accelerate their reproduction compared to those who did not experience early adversity. Further, while accelerated reproduction predicted increased lifetime reproductive success overall, these benefits were not specific to females who experienced early life adversity. Instead, females only benefited from reproductive acceleration if they also led long lives. Our results call into question the theory that accelerated reproduction is an adaptive response to early life adversityin baboons and other long-lived species.</span></span></span></span></span></span></span></span></span></span></span></p>
Data from: Cumulative early life adversity predicts longevity in wild baboons
In humans and other animals, harsh circumstances in early life predict morbidity and mortality in adulthood. Multiple adverse conditions are thought to be especially toxic, but this hypothesis has rarely been tested in a prospective, longitudinal framework, especially in long-lived mammals. Here we use prospective data on 196 wild female baboons to show that cumulative early adversity predicts natural adult lifespan. Females who experience ≥3 sources of early adversity die a median of 10 years earlier than females who experience ≤1 adverse circumstances (median lifespan is 18.5 years). Females who experience the most adversity are also socially isolated in adulthood, suggesting that social processes partially explain the link between early adversity and adult survival. Our results provide powerful evidence for the developmental origins of health and disease and indicate that close ties between early adversity and survival arise even in the absence of health habit and health care-related explanations.
Rhesus macaques compensate for reproductive delay following ecological adversity early in life
<p>Adversity early in life can shape the reproductive potential of individuals through negative effects on health and life span. However, long-lived populations with multiple reproductive events may present alternative life history strategies to optimize reproductive schedules and compensate for shorter life spans. Here, we quantify the effects of major hurricanes and density dependence as sources of early-life ecological adversity on Cayo Santiago rhesus macaque female reproduction and decompose their effects onto the mean age-specific fertility, reproductive pace, and lifetime reproductive success (LRS). Females experiencing major hurricanes exhibit a delayed reproductive debut but maintain the pace of reproduction past debut and show a higher mean fertility during prime reproductive ages, relative to unaffected females. Increasing density at birth is associated to a decrease in mean fertility and reproductive pace, but such association is absent at intermediate densities. When combined, our study reveals that hurricanes early in life predict a delay-overshoot pattern in mean age-specific fertility that supports the maintenance of LRS. In contrast to predictive adaptive response models of accelerated reproduction, this long-lived population presents a novel reproductive strategy where females who experience major natural disasters early in life ultimately overcome their initial reproductive penalty with no major negative fitness outcomes. Density presents a more complex relation with reproduction that suggests females experiencing a population regulated at intermediate densities early in life will escape density dependence and show optimized reproductive schedules. Our results support hypotheses about life history trade-offs in which adversity-affected females ensure their future reproductive potential by allocating more energy to growth or maintenance processes at younger adult ages.</p>
Probing the Role of Mitochondrial Oxidative Stress in Impaired Vascular Function Among Young Adults With Early Life Adversity
ClinicalTrials.gov study NCT07244809. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Remote Mindfulness Training Following Early Life Adversity
ClinicalTrials.gov study NCT05516108. IPD Sharing: YES. Countries: 1. Publications: 0.
Data from: Organizing effects of adverse early-life condition on body mass, compensatory growth and reproduction: experimental studies in rock pigeons
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Data from: Cumulative early life adversity predicts longevity in wild baboons
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Accelerated reproduction is not an adaptive response to early life adversity in wild baboons
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Data from: Sex-specific effects of early-life adversity on adult fitness in a wild mammal
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Altered corticolimbic connectivity reveals sex-specific adolescent outcomes in a rat model of early life adversity
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Rhesus macaques compensate for reproductive delay following ecological adversity early in life
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An App-based Mindfulness Intervention for Sexual Minority Women With a History of Early Life Adversities (ELA)
ClinicalTrials.gov study NCT05201391. IPD Sharing: YES. Countries: 1. Publications: 0.
Data from: The ecological roots of human susceptibility to social influence: a pre-registered study investigating the impact of early life adversity
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Intra-individual methylomics detects the impact of early-life adversity
GEO Series GSE119640. Rattus norvegicus. 38 samples. Type: Methylation profiling by high throughput sequencing.
The Biological Embedding of Early Life Socioeconomic and Family Adversity in Children’s Genome-wide DNA Methylation
GEO Series GSE94734. Homo sapiens. 178 samples. Type: Methylation profiling by genome tiling array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.