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33 results for “early senescence”
Supplementary material - Non-invasive Multimodal Imaging Reveals Early Therapy-Induced Senescence in Human Cancer Cells
<p>The repository features .xls and .txt worksheets including all the data used through this work and reported in the manuscript figures and graphs. More precisely, we included the following: </p> <ul> <li>Figure 2. Raw pixel-wise signals detected in NLO images of TIS cells control cells that were used to perform the colocalization graphs and analyses reported. We describe the average colocalization of SRS and F-CARS signals, and TPEF and E-CARS signals, in both phenotypes.</li> <li>Figure 4. Raw data from image analyses of TPEF and SRS channels of multimodal NLO images, divided in 5 different time points over the therapy follow-up period. The data describe the early rearrangement of mitochondria (TPEF) and lipid vesicles (SRS) in TIS cells, with respect to control counterparts.</li> <li>Figure 6. Raw data from image analyses of QPI images, divided in 4 different time points over the therapy follow-up period. The data describe the early morphological modifications of TIS cells, with respect to control counterparts.</li> </ul>
Data from: Senescence and early-life performance as predictors of lifespan in a solitary bee
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Data from: Sex differences in senescence: the role of intra-sexual competition in early adulthood
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Data from: The impact of reproductive investment and early-life environmental conditions on senescence: support for the disposable soma hypothesis
Several hypotheses have been put forward to explain the evolution of senescence. One of the leading hypotheses, the disposable soma hypothesis, predicts a trade-off, whereby early-life investment in reproduction leads to late-life declines in survival (survival senescence). Testing this hypothesis in natural populations is challenging, but important for understanding the evolution of senescence. We used the long-term data set from a contained, predator-free population of individually marked Seychelles warblers (Acrocephalus sechellensis) to investigate how age-related declines in survival are affected by early-life investment in reproduction and early-life environmental conditions. The disposable soma hypothesis predicts that higher investment in reproduction, or experiencing harsh conditions during early life, will lead to an earlier onset, and an increased rate, of senescence. We found that both sexes showed similar age-related declines in late-life survival consistent with senescence. Individuals that started breeding at a later age showed a delay in survival senescence, but this later onset of breeding did not result in a less rapid decline in late-life survival. Although survival senescence was not directly related to early-life environmental conditions, age of first breeding increased with natal food availability. Therefore, early-life food availability may affect senescence by influencing age of first breeding. The disposable soma hypothesis of senescence is supported by delayed senescence in individuals that started breeding at a later age and therefore invested less in reproduction.
Data from: Early and adult social environments shape sex-specific actuarial senescence patterns in a cooperative breeder
Sociality modulates life history traits through changes in resource allocation to fitness-related traits. However, how social factors at different stages of the life cycle modulate senescence remains poorly understood. To address this question, we assessed the influence of social environment in both early life and adulthood on actuarial senescence in the Alpine marmot, a cooperative breeder. The influence of helpers on actuarial senescence strongly differed depending on when help was provided, and on the sex of the dominant. Being helped when adult slowed down senescence in both sexes. However, the effect of the presence of helpers the year of birth of a dominant was sex-specific. Among dominants helped during adulthood, females born in the presence of helpers senesced slower, whereas males senesced faster. Among dominants without helpers during adulthood, females with helpers at birth senesced faster. Social environment modulates senescence, but acts differently between sexes and life stages.
Data from: The impact of reproductive investment and early-life environmental conditions on senescence: support for the disposable soma hypothesis
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Data from: Early and adult social environments shape sex-specific actuarial senescence patterns in a cooperative breeder
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Data from: Early life expenditure in sexual competition is associated with increased reproductive senescence in male red deer
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Data from: Early reproductive investment, senescence and lifetime reproductive success in female Asian elephants
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Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension
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PDZK1 Protects Against RPE Senescence by Targeting the 14-3-3ε-mTOR Axis to Attenuate Early Diabetic Retinopathy [MG_HG]
GEO Series GSE304690. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
Topological demarcation by HMGB2 is disrupted early upon senescence entry and induces CTCF clustering across cell types
GEO Series GSE98448. Homo sapiens. 53 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Other.
Vascular senescence and leak are features of the early breakdown of the blood-brain barrier in Alzheimer’s disease models.
GEO Series GSE243576. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Adaptation Versus Senescence In Rice: Early Signalling Events Play A Role In Inducing Specificity And Tolerance To Salinity
GEO Series GSE109341. Oryza sativa Japonica Group. 24 samples. Type: Expression profiling by high throughput sequencing.
Circadian Clock Regulation in Soybean Senescence: A Transcriptome Analysis of Early and Late Senescence Types
GEO Series GSE275263. Glycine max. 2 samples. Type: Expression profiling by high throughput sequencing.
PDZK1 Protects Against RPE Senescence by Targeting the 14-3-3ε-mTOR Axis to Attenuate Early Diabetic Retinopathy
GEO Series GSE304545. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Topological demarcation by HMGB2 is disrupted early upon senescence entry and induces CTCF clustering across cell types [ChIP-Seq]
GEO Series GSE98245. Homo sapiens. 7 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Topological demarcation by HMGB2 is disrupted early upon senescence entry and induces CTCF clustering across cell types [RNA-seq]
GEO Series GSE98440. Homo sapiens. 26 samples. Type: Expression profiling by high throughput sequencing.
Topological demarcation by HMGB2 is disrupted early upon senescence entry and induces CTCF clustering across cell types [HiChIP]
GEO Series GSE100856. Homo sapiens. 4 samples. Type: Other.
Topological demarcation by HMGB2 is disrupted early upon senescence entry and induces CTCF clustering across cell types [DROP-seq]
GEO Series GSE102090. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.