Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
21
datasets available to search
ShareScore release 0.9.0
Dataset results
21 results for “elastin”
Elastin-like polypeptide-based bioink for human skin dermal compartment reconstruction
<p>Raw data from the article</p>
Data from: Flow imaging microscopy as a novel tool for high-throughput evaluation of elastin-like polymer coacervates
Biological and bioinspired polymer microparticles have broad biomedical and industrial applications, including drug delivery, tissue engineering, surface modification, environmental remediation, imaging, and sensing. Full realization of the potential of biopolymer microparticles will require methods for rigorous characterization of particle sizes, morphologies, and dynamics, so that researchers may correlate particle characteristics with synthesis methods and desired functions. Toward this end, we evaluated biopolymer microparticles using flow imaging microscopy. This technology is widely used in the biopharmaceutical industry but is not yet well-known among the materials community. Our polymer, a genetically engineered elastin-like polypeptide (ELP), self-assembles into micron-scale coacervates. We performed flow imaging of ELP coacervates using two different instruments, one with a lower size limit of approximately 2 microns, the other with a lower size limit of approximately 300 nanometers. We validated flow imaging results by comparison with dynamic light scattering and atomic force microscopy analyses. We explored the effects of various solvent conditions on ELP coacervate size, morphology, and behavior, such as the dispersion of single particles versus aggregates. We found that flow imaging is a superior tool for rapid and thorough particle analysis of ELP coacervates in solution. We anticipate that researchers studying many types of microscale protein or polymer assemblies will be interested in flow imaging as a tool for quantitative, solution-based characterization.
The Effects of Discontinuation of Vitamin K Antagonists on the Rate of Elastin Degradation
ClinicalTrials.gov study NCT03285100. IPD Sharing: UNDECIDED. Countries: 1. Publications: 11.
Impact of Elastin Mediated Vascular Stiffness on End Organs
ClinicalTrials.gov study NCT02840448. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Fragmentation of Elastin as a Biological Marker of Frailty and Impact in Tumor Progression in Elderly Patients With Cancer
ClinicalTrials.gov study NCT02807129. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Flow imaging microscopy as a novel tool for high-throughput evaluation of elastin-like polymer coacervates
Open the record for dataset details and reuse information.
Effect of elastin insufficiency on gene expression in cultured human aortic smooth muscle cells
GEO Series GSE270681. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Effect of elastin-deficiency on gene expression in murine aortic smooth muscle cells at embryonic day 15.5
GEO Series GSE270682. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Removal of elastin from the cell surface of primary human hepatocytes
GEO Series GSE299848. Homo sapiens. 12 samples. Type: Expression profiling by array.
Ecto-5’-Nucleotidase (Nt5e/CD73)-Mediated Adenosine Signaling Attenuates TGFβ-2 Induced Elastin and Cellular Contraction
GEO Series GSE216727. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Data Set for Manuscript: Citrullination, a novel post-translational modification of elastin, is involved in COPD Pathogenesis
<p>Elastin is an extracellular matrix protein (ECM) that supports elasticity of the lung, and in patients with chronic obstructive pulmonary disease (COPD) and emphysema, the structural changes that reduce the amount of elastic recoil, lead to loss of pulmonary function. We recently demonstrated that elastin is a target of peptidyl arginine deiminase (PAD) enzyme-induced citrullination, thereby leading to enhanced susceptibility of this ECM protein to proteolysis. The current study aimed to investigate the impact of PAD activity in vivo and furthermore assessed whether pharmacological inhibition of PAD activity protects against pulmonary emphysema. </p>
Bipolar RF Microneedling for Improved Laxity and Lift of the Submental and Neck Tissue and Effect on Elastin
ClinicalTrials.gov study NCT04245696. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Efficacy of Collagen-elastin Dermal Substitute in the Treatment of Loss of Cutaneous Substances With Skin Grafts
ClinicalTrials.gov study NCT02090361. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluating Genetic Factors That May Contribute to Elastin Function and the Development of Chronic Obstructive Pulmonary Disease
ClinicalTrials.gov study NCT00725309. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Quantification of Elastin Markers Synthesis in Williams-Beuren Syndrome and 7q11.23 Micro-duplication Syndrome
ClinicalTrials.gov study NCT04051086. IPD Sharing: NO. Countries: 1. Publications: 0.
Role of Elastin Metabolites in Aortic Remodelling in AS
ClinicalTrials.gov study NCT03883490. IPD Sharing: NO. Countries: 1. Publications: 0.
Dynamic Changes in the Expressions of Elastogenesis- and Elastinolysis-Associated Genes and Remodeling of the Elastin Network in Volume-Overloaded Heart
GEO Series GSE97044. Rattus norvegicus. 16 samples. Type: Expression profiling by array.
Single cell RNA sequencing of ascending aorta in smooth muscle-targeted elastin deletion
GEO Series GSE193262. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profiling of Elastin (ELN) knock-down in human fibroblast MRC5
GEO Series GSE268042. Homo sapiens. 9 samples. Type: Expression profiling by array.
Crosslinked elastin-like polypeptides mediate direct cardiac differentiation of mouse embryonic and induced pluripotent stem cells without use of cardiac differentiation factors
GEO Series GSE145623. Mus musculus. 12 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.