Find research datasets worth reusing

Study of Lanreotide Autogel 120 mg in Patients With Non-functioning Entero- Pancreatic Endocrine Tumour

ClinicalTrials.gov study NCT00842348. IPD Sharing: YES. Countries: 9. Publications: 2.

Study of Lanreotide Autogel in Non-functioning Entero-pancreatic Endocrine Tumours

ClinicalTrials.gov study NCT00353496. IPD Sharing: YES. Countries: 15. Publications: 3.

Personalized Mobile Intervention to Reduce Exposure to Endocrine Disrupting Chemicals in Adults of Child-Bearing Age

ClinicalTrials.gov study NCT05780047. IPD Sharing: YES. Countries: 1. Publications: 55.

Adjuvant Ribociclib With Endocrine Therapy in Hormone Receptor+/HER2- High Risk Early Breast Cancer

ClinicalTrials.gov study NCT03078751. IPD Sharing: YES. Countries: 1. Publications: 1.

Study Assessing the Efficacy and Safety of Alpelisib Plus Fulvestrant or Letrozole, Based on Prior Endocrine Therapy, in Patients With PIK3CA Mutant, HR+, HER2- Advanced Breast Cancer Who Have Progres

ClinicalTrials.gov study NCT03056755. IPD Sharing: YES. Countries: 19. Publications: 4.

Comparing an Operation to Monitoring, With or Without Endocrine Therapy (COMET) Trial For Low Risk DCIS

ClinicalTrials.gov study NCT02926911. IPD Sharing: YES. Countries: 1. Publications: 8.

opencc-zeroJun 2020View details →

Endocrine disruptors cause multigenerational and transgenerational epigenetic changes in fish exposed during early life

The inland silverside, Menidia beryllina, is a euryhaline fish and a model organism in ecotoxicology. We previously showed that exposure to picomolar (ng/L) levels of endocrine disrupting chemicals (EDCs) can cause a variety of effects in M. beryllina, from changes in gene expression to phenotypic alterations. Here we explore the potential for early life exposure to EDCs to modify the epigenome in silversides, with a focus on multi- and transgenerational effects. EDCs included contaminants of emerging concern (the pyrethroid insecticide bifenthrin and the synthetic progestin levonorgestrel), as well as a commonly detected synthetic estrogen (ethinylestradiol), and a synthetic androgen (trenbolone) at exposure levels ranging from 3 to 10 ng/L. In a multigenerational experiment, we exposed parental silversides to EDCs from fertilization until 21 days post hatch (dph). Then we assessed DNA methylation patterns for three generations (F0, F1, and F2) in whole body larval fish using reduced representation bisulfite sequencing (RRBS). We found significant ( = 0.05) differences in promoter and/or gene body methylation in treatment fish relative to controls for all EDCs and all generations indicating that both multigenerational (F1) and transgenerational (F2) effects that were caused by strict inheritance of DNA methylation alterations and the dysregulation of epigenetic control mechanisms. Using gene ontology and pathway analyses, we found enrichment in biological processes and pathways representative of growth and development, immune function, reproduction, pigmentation, epigenetic regulation, stress response and repair (including pathways important in carcinogenesis). Further, we found that a subset of potentially EDC responsive genes (EDCRGs) were differentially methylated across all treatments and generations and included hormone receptors, genes involved in steroidogenesis, prostaglandin synthesis, sexual development, DNA methylation, protein metabolism and synthesis, cell signaling, and neurodevelopment. The analysis of EDCRGs provided additional evidence that differential methylation is inherited by the offspring of EDC-treated animals, sometimes in the F2 generation that was never exposed. These findings show that low, environmentally relevant levels of EDCs can cause altered methylation in genes that are functionally relevant to impaired phenotypes documented in EDC-exposed animals and EDC exposure has the potential to affect epigenetic regulation in fish that have not been directly exposed.

opencc-zeroJun 2020View details →

Endocrine regulation of egg rejection in an avian brood parasite host

Parasite-host coevolution can lead to novel behavioural adaptations in hosts to resist parasitism. In avian obligate brood parasite and host systems, many hosts species have evolved diverse cognitive and behavioural traits to recognize and reject parasitic eggs. Our understanding of the evolution and ecology of these defences hinges on our understanding of the mechanisms that regulate them. We hypothesized that corticosterone, a hormone linked to the stress-response, vigilance, and the suppression of parental behaviour, stimulates the rejection of foreign eggs by brood parasite hosts. We experimentally reduced circulating glucocorticoid levels with mitotane injections in American robins Turdus migratorius and found that the mitotane-treated birds rejected foreign eggs at a lower frequency compared to the sham-treated subjects. This is the first study to causally identify a potential mechanism of a widespread defence behaviour, and it is consistent with egg rejection being mediated by stress physiology.

opencc-zeroDec 2016View details →

Data from: Heritable variation in circulating glucocorticoids and endocrine flexibility in a free-living songbird

Phenotypic flexibility is a central way that organisms cope with challenging and changing environments. As endocrine signals mediate many phenotypic traits, heritable variation in hormone levels, or their context-dependent flexibility, could present an important target for selection. Several studies have estimated the heritability of circulating glucocorticoid levels under acute stress conditions, but little is known about the potential for either baseline hormone levels or rapid endocrine flexibility to evolve. Here we assessed the potential for selection to operate on the elevation (circulating hormone levels) and flexibility of glucocorticoid reaction norms to acute restraint stress. Multivariate animal models revealed low but significant heritability in baseline (h2=0.13-0.14) and stress-induced glucocorticoids (h2=0.18), and moderate heritability in glucocorticoid flexibility in response to acute stress (h2=0.38) in free-living juvenile tree swallows (Tachycineta bicolor; n=408). Baseline glucocorticoids were not genetically correlated with either stress-induced glucocorticoids or glucocorticoid flexibility. These findings indicate that baseline glucocorticoids and the acute stress response are distinct traits that can be independently shaped by selection. Microevolutionary changes that influence the expression or flexibility of these endocrine mediators of phenotype may be an important way that populations adapt to changing environments and novel threats.

opencc-zeroMar 2022View details →

Does scent attractiveness reveal women's ovulatory timing? Evidence from signal detection analyses and endocrine predictors of odor attractiveness

Odor cues associated with shifts in ovarian hormones indicate ovulatory timing in females of many nonhuman species. Although prior evidence supports women's body odors smelling more attractive on days when conception is possible, that research has left ambiguous how diagnostic of ovulatory timing odor cues are, as well as whether shifts in odor attractiveness are correlated with shifts in ovarian hormones. Here, 46 women each provided 6 overnight scent and corresponding day saliva samples spaced 5 days apart, and completed luteinizing hormone tests to determine ovulatory timing. Scent samples collected near ovulation were rated more attractive, on average, relative to samples from the same women collected on other days. Importantly, however, signal detection analyses showed that rater discrimination of fertile window timing from odor attractiveness ratings was very poor. Within-women shifts in salivary estradiol and progesterone were not significantly associated with within-women shifts in odor attractiveness. Between-women, mean estradiol was positively associated with mean odor attractiveness. Our findings suggest that raters cannot reliably detect women's ovulatory timing from their scent attractiveness. The between-women effect of estradiol raises the possibility that women's scents provide information about overall cycle fecundity, though further research is necessary to rigorously investigate this possibility.

opencc-zeroAug 2022View details →

Data from: Metabolic changes associated with two endocrine abnormalities in dogs: elevated fructosamine and low thyroxine

Metabolomics studies in canine endocrine abnormalities are sparse and basic information on these abnormalities must be generated. This dataset includes the 1H NMR metabolic profiling results of 151 dog serum samples. The samples have been collected in an ethical way, being leftovers of clinical diagnostic samples. The sample set includes 25 control samples based on unremarkable routine clinical chemistry and hematology, 79 samples exhibiting high fructosamine which reflects poor glycemic control, and 47 samples with low thyroxine, a metabolically important thyroid hormone. The metabolite data and metadata were utilized in the study: Ottka et al. Metabolic changes associated with two endocrine abnormalities in dogs: elevated fructosamine and low thyroxine. The control group results were utilized also in: Ottka et al. Serum NMR metabolomics uncovers multiple metabolic changes in phenobarbital-treated dogs.