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5 results for “endogenous plasticity”
High-resolution imaging and manipulation of endogenous AMPA receptor surface mobility during synaptic plasticity and learning
<p><span>Data set for the MS</span></p>
Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors
<p>Elucidating how synaptic molecules such as AMPA receptors mediate neuronal communication and tracking their dynamic expression during behavior is crucial to understand cognition and disease, but current technological barriers preclude large-scale exploration of molecular dynamics in vivo. We have developed a suite of innovative methodologies that break through these barriers: a new knockin mouse line with fluorescently tagged endogenous AMPA receptors, two-photon imaging of hundreds of thousands of labeled synapses in behaving mice, and computer vision-based automatic synapse detection. Using these tools, we can longitudinally track how the strength of populations of synapses changes during behavior. We used this approach to generate an unprecedentedly detailed spatiotemporal map of synapses undergoing changes in strength following sensory experience. More generally, these tools can be used as an optical probe capable of measuring functional synapse strength across entire brain areas during any behavioral paradigm, describing complex system-wide changes with molecular precision.</p>
Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors
Open the record for dataset details and reuse information.
Plasticity of Neonatal Neuronal Networks Temporal Theta Activity, the First Endogenous
ClinicalTrials.gov study NCT03677908. IPD Sharing: NO. Countries: 0. Publications: 0.
Endothelial Extracellular Vesicles Contribute to the Malignant Plasticity of Prostate Cancer cells in Concert with Endogenous Twist1
GEO Series GSE208209. Homo sapiens. 46 samples. Type: Expression profiling by array; Non-coding RNA profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.