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837
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ShareScore release 0.9.0
Dataset results
837 results for “endometrial cancer”
ZW25 in Women With Endometrial Cancers
ClinicalTrials.gov study NCT04513665. IPD Sharing: YES. Countries: 1. Publications: 1.
Endometrial Cancer (All histologies) bGWAS results
<p>Output from multi-trait GWAS analysis of endometrial cancer and risk factors using bGWAS software. This includes results from Bayes Factor analysis, and assessment of posterior and direct effects.</p>
Proteomic characterization of intra-tumor heterogeneity in human endometrial cancer.
<p>Endometrial cancer (EC) is one of the most frequently diagnosed gynecological cancers worldwide, and its prevalence has increased by more than 50% over the last two decades. Despite the understanding of the major signaling pathways driving the growth and metastasis of EC cells, clinical trials targeting these signaling pathways in human patients have reported poor outcomes. Heterogeneous nature of EC is suspected to be one of the key reasons for the failure of targeted therapies. However, no study so far has explored EC heterogeneity within the same patient at the proteomic level. In this study, we isolated proteins from tumor tissue samples obtained from different sites of EC from individual patients (~2-4 samples/patient). We then performed a SWATH-based comparative proteomic analysis, using liquid chromatography-tandem mass spectrometry (LC-MS/MS), to profile the protein content of different areas within EC tissue. Our results highlighted an average of 1424 unique proteins in 20 patient-derived EC tissues with a confidence corresponding to a false discovery rate below 1%. We have identified protein biomarkers that differentiate between premenopausal vs postmenopausal cancer, macroscopic vs microscopic tumor, more vs less invasive cancer, and DNA mismatch repair defective vs intact tumor. Furthermore, the data revealed a list of unique proteins that, for the same patient, exist only in a single EC location but are not present in other locations within the same tumor. Overall, our proteomic analysis highlighted that tumor tissue samples collected from different sites of EC within the same patient can harbor diverse protein profiles. Importantly, this study sets the foundation for further investigations into the mechanisms of endometrial heterogeneity and some of the proteins identified here may represent potential novel EC drug targets.</p>
Proteome association studies of breast, prostate, ovarian, and endometrial cancers implicate plasma protein regulation in cancer susceptibility
<p>Full results datasets for Proteome association studies of breast, prostate, ovarian, and endometrial cancers implicate plasma protein regulation in cancer susceptibility:</p> <p>ALL*all_pheno.csv are TOPMed-MESA combined-ancestry models, discovery and replication cohorts</p> <p>ARIC_EA_all_pheno.csv is ARIC European-American ancestry models, discovery cohort</p> <p>ARIC*meta_all.txt is ARIC European-American ancestry models, discovery and replication cohorts, with meta-analysis of disc+rep</p>
Observational Study of Women With Endometrial Cancer Who Receive the Standard Treatment for Their Disease
ClinicalTrials.gov study NCT04291612. IPD Sharing: YES. Countries: 4. Publications: 1.
ONC201 in Recurrent/Refractory Metastatic Breast Cancer and Advanced Endometrial Carcinoma
ClinicalTrials.gov study NCT03394027. IPD Sharing: YES. Countries: 1. Publications: 4.
Refining Adjuvant Treatment in Endometrial Cancer Based on Molecular Features
ClinicalTrials.gov study NCT05255653. IPD Sharing: YES. Countries: 4. Publications: 2.
A Study of Durvalumab With or Without Tremelimumab in Endometrial Cancer
ClinicalTrials.gov study NCT03015129. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Real-time Lymphatic Channel Visualization Improves Bilateral Sentinel Lymph Node Detection in Endometrial Cancer
ClinicalTrials.gov study NCT05191212. IPD Sharing: NO. Countries: 1. Publications: 3.
Letrozole and RAD001 With Advanced or Recurrent Endometrial Cancer
ClinicalTrials.gov study NCT01068249. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Intensity-Modulated Radiation Therapy, Cisplatin, and Bevacizumab Followed by Carboplatin and Paclitaxel in Treating Patients Who Have Undergone Surgery for Endometrial Cancer
ClinicalTrials.gov study NCT01005329. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Testing the Addition of the Immunotherapy Drug Pembrolizumab to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) in Stage III-IV or Recurrent Endometrial Cancer
ClinicalTrials.gov study NCT03914612. IPD Sharing: YES. Countries: 5. Publications: 3.
Pelvic Radiation Therapy or Vaginal Implant Radiation Therapy, Paclitaxel, and Carboplatin in Treating Patients With High-Risk Stage I or Stage II Endometrial Cancer
ClinicalTrials.gov study NCT00807768. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Carboplatin and Paclitaxel With or Without Cisplatin and Radiation Therapy in Treating Patients With Stage I, Stage II, Stage III, or Stage IVA Endometrial Cancer
ClinicalTrials.gov study NCT00942357. IPD Sharing: Not stated. Countries: 3. Publications: 3.
Adipocytokines in Endometrial Cancer
ClinicalTrials.gov study NCT04697264. IPD Sharing: NO. Countries: 1. Publications: 10.
Concurrent Use Lymphoseek & Indocyanine Green in Sentinel Lymph Node Detection in Endometrial Cancer
ClinicalTrials.gov study NCT04511026. IPD Sharing: NO. Countries: 1. Publications: 1.
Levonorgestrel-Releasing Intrauterine System in Treating Patients With Complex Atypical Hyperplasia or Grade I Endometrial Cancer
ClinicalTrials.gov study NCT00788671. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Zoptarelin Doxorubicin (AEZS 108) as Second Line Therapy for Endometrial Cancer
ClinicalTrials.gov study NCT01767155. IPD Sharing: Not stated. Countries: 22. Publications: 1.
Pembrolizumab in Ultramutated and Hypermutated Endometrial Cancer
ClinicalTrials.gov study NCT02899793. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Standard Versus Intensity-Modulated Pelvic Radiation Therapy in Treating Patients With Endometrial or Cervical Cancer
ClinicalTrials.gov study NCT01672892. IPD Sharing: Not stated. Countries: 4. Publications: 4.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.