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ShareScore release 0.9.0
Dataset results
68 results for “enhancer deletion”
ASIC2 Deletion in Medial Prefrontal Cortex Enhances Social Dominance in Mice
<p>Social dominance is essential for maintaining a stable social society and has well-established positive and negative impacts on sociable animals, including humans. However, the regulatory mechanisms governing social dominance, as well as the crucial regulators and biomarkers involved, remain poorly understood. We discover that mice lacking acid-sensing ion channel 2 (ASIC2) exhibit a persistent higher social dominance ranking compared to their wild-type cagemates. Conversely, the overexpression of ASIC2 in the medial prefrontal cortex (mPFC) reverses the dominance hierarchy observed in ASIC2 knockout mice. ASIC2 deletion prolongs the inactivation time of ASICs, resulting in enhanced ASIC-dependent synaptic transmission and plasticity in the mPFC through the protein kinase A signaling pathway. Furthermore, ASIC2 exhibits distinct functional roles in excitatory and inhibitory neurons, thereby modulating the balance of neuronal activities underlying social dominance behaviors—a phenomenon suggestive of a cell-subtype-specific mechanism. Finally, this research establishes a foundational understanding of the mechanisms governing social dominance formation, offering potential insights for the management or prevention of social disorders, such as depression and anxiety.</p>
Deletion of a state-specific PD-1 enhancer modulates exhausted T cell fate and function [RNA-Seq]
GEO Series GSE269580. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Abnormal microglia and enhanced inflammation-related gene transcription in mice with conditional deletion of Ctcf in Camk2a-Cre-expressing neurons [Whole_HC_CTCF]
GEO Series GSE108825. Mus musculus. 8 samples. Type: Expression profiling by array.
Enhancing co-translational folding of heterologous protein by deleting non-essential ribosomal proteins in Pichia pastoris
GEO Series GSE116415. Komagataella pastoris. 60 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profiling of teloHAEC cells with CRISPR-Cas9-mediated deletion of candidate enhancer regions
GEO Series GSE191253. Homo sapiens. 27 samples. Type: Expression profiling by high throughput sequencing.
Nfkbid-overexpression and -ablation enhances thymic deletion of autoreactive AI4 CD8 T-cells
GEO Series GSE176566. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
scRNAseq in Pten enhancer wild-type or deleted thymocytes, enriched for immature thymocyte stages (CD4-CD3-)
GEO Series GSE156070. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Fat1 deletion promotes hybrid EMT state with enhanced tumor progression, stemness, and metastasis (mouse RNA-Seq)
GEO Series GSE158502. Mus musculus. 23 samples. Type: Expression profiling by high throughput sequencing.
CRISPR/Cas9 mediated deletion of the adenosine A2AR enhances CAR T cell efficacy [murine_CRISPR_A2AKO_RNA-seq]
GEO Series GSE156191. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Abnormal microglia and enhanced inflammation-related gene transcription in mice with conditional deletion of Ctcf in Camk2a-Cre-expressing neurons
GEO Series GSE108827. Mus musculus. 16 samples. Type: Expression profiling by array.
Deletion of Klotho enhancer deepens sexual dimorphism of gene expression without impacting female resistance to kidney injury [RNA exp1]
GEO Series GSE243945. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
RNAseq in Pten enhancer wild-type or deleted mouse T-ALLs
GEO Series GSE150894. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Deletion of a state-specific PD-1 enhancer modulates exhausted T cell fate and function [scRNA-seq]
GEO Series GSE212379. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Fat1 deletion promotes hybrid EMT state with enhanced tumor progression, stemness, and metastasis (human RNA-Seq)
GEO Series GSE158501. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Microenvironmental CXCL12 Deletion Enhances Flt3-ITD Acute Myeloid Leukemia Stem Cell Response to Therapy by Reducing p38 MAPK Signaling
GEO Series GSE212428. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
CRISPR/Cas9 mediated deletion of the adenosine A2AR enhances CAR T cell efficacy [NECA_RNA-seq]
GEO Series GSE156189. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
RNA-sequencing data for 923 enhancer deletion newborn mouse whole skin
GEO Series GSE158869. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
CRISPR/Cas9 mediated deletion of the adenosine A2AR enhances CAR T cell efficacy [human_CRISPR_A2AKO_RNA-seq]
GEO Series GSE156190. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Deleting DNMT3A in CAR T cells prevents exhaustion and 1 enhances antitumor activity
GEO Series GSE184568. Homo sapiens. 41 samples. Type: Methylation profiling by high throughput sequencing.
Fat1 deletion promotes hybrid EMT state with enhanced tumor progression, stemness, and metastasis
GEO Series GSE158506. Mus musculus; Homo sapiens. 62 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.