Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
43
datasets available to search
ShareScore release 0.9.0
Dataset results
43 results for “entorhinal”
Phase coding of spatial representations in the human entorhinal cortex
<p>Supporting Preprocessed Electrophysiology Data for the article titled "Phase coding of spatial representations in the human entorhinal cortex".</p> <p>Data were preprocessed and analyzed using Matlab.</p> <p>Data, after decompression, are organized hierarchically in folders and subfolders (two levels).</p> <p>Main folder names are composed as subjectID_date_EC_DATA_taskNo</p> <p>Sub-folders named as: CHn_single-unit ID </p> <p>[subjectID, date, task num] + [Electrode channel, and single-unit ID] </p> <p>subjectID: (subject1, subject2)</p> <p>date: mmm-dd</p> <p>task: (1,2,3,4) Virtual environments (1: backyard, 2: Louvre, 3: Luxor, 4: desert)</p> <p>electrode Channel: CH1,CH2, CH3, CH4, CH5</p> <p>single-unit ID: 0, 1, 2, 3, 4, 5, 6</p> <p>For each channel and single-unit, the following 9 datasets were computed and saved. For instance, for the first electrode and first single-unit class (CH=1, cell ID= 0):</p> <p>CH1_Clu0.mat -- Summary of firing features of this single-unit including firing rate, and grid score of the cell. (In Matlab mat format)<br> CH1_Clu0_MeanPhaseMap.csv -- Mean spike phase map relative to gamma-band LFP<br> CH1_Clu0_Phase.csv -- Spike phase CH1_Clu0_spikeData.csv<br> CH1_Clu0_spkT.csv -- Spike times in increental order<br> CH1_Clu0_VarPhaseMap.csv -- Map of the variance of spike times in increental order<br> CH1_Clu0_xval.mat -- Summary of firing features of 50% of single-unit spikes (every other spike) for cross-validation purposes. (In Matlab mat format)<br> CH1_Clu0_xyPos.csv -- X,Y coordinates of the avatar's position in 1 ms resolution. In other words, the path taken by the avatar sampled at 1 kHz.<br> CH1_Clu0_XYspkT.csv -- X,Y coordinates of the avatar at moments of spikes. In other words, the location in space where a spike was fired by the putative neuron.</p> <p> </p>
The entorhinal cortex modulates trace fear memory formation and neuroplasticity in the lateral amygdala via cholecystokinin
<p>Although the neural circuitry underlying fear memory formation is important in fear-related mental disorders, it is incompletely understood. Here, we utilized trace fear conditioning to study the formation of trace fear memory. We identified the entorhinal cortex (EC) as a critical component of sensory signaling to the amygdala. Moreover, we used the loss of function and rescue experiments to demonstrate that release of the neuropeptide cholecystokinin (CCK) from the EC is required for trace fear memory formation. We discovered that CCK-positive neurons extend from the EC to the lateral nuclei of the amygdala (LA), and inhibition of CCK-dependent signaling in the EC prevented long-term potentiation of sensory signals to the LA and formation of trace fear memory. Altogether, we suggest a model where sensory stimuli trigger the release of CCK from EC neurons, which potentiates sensory signals to the LA, ultimately influencing neural plasticity and trace fear memory formation.</p>
The entorhinal cortex modulates trace fear memory formation and neuroplasticity in the lateral amygdala via cholecystokinin
Open the record for dataset details and reuse information.
Spatial coding dysfunction and network instability in the aging medial entorhinal cortex
Open the record for dataset details and reuse information.
Impact of the entorhinal feed-forward connection to the CA3 on hippocampal coding
Open the record for dataset details and reuse information.
Data from: ASHS-OAP atlas for automatic entorhinal cortex segmentation
<p>Early stages of Alzheimer's disease (AD) are associated with volume reductions in specific subregions of the medial temporal lobe (MTL). Using a manual segmentation method—the Olsen-Amaral-Palombo (OAP) protocol— previous work in healthy older adults showed that reductions in grey matter volumes in MTL subregions were associated with lower scores on the Montreal Cognitive Assessment (MoCA), suggesting atrophy may occur prior to diagnosis of mild cognitive impairment, a condition that often progresses to AD. However, current manual segmentation methods are labour intensive and time consuming. Here, we examined the utility of Automatic Segmentation of Hippocampal Subfields (ASHS) to detect volumetric differences in MTL subregions of healthy older adults who varied in cognitive status as determined by the MoCA. We trained ASHS on the OAP protocol to create the ASHS-OAP atlas, and then examined how well automated segmentation replicated the ground truth of manual segmentation. Volumetric measures obtained from the ASHS-OAP atlas were also contrasted against those from the ASHS-PMC atlas, a widely used atlas provided by the ASHS team. Volumetrics from the ASHS-OAP atlas aligned well with those from manual segmentation, suggesting ASHS-OAP is a viable alternative to current manual segmentation methods. In addition, while some subtle differences were observed, results from the ASHS-PMC and ASHS-OAP atlases aligned well with each other overall. Our findings highlight the utility of automated segmentation methods but still underscore the need for a unified and harmonized MTL segmentation atlas.</p>
Theta oscillations coordinate grid-like representations between ventromedial prefrontal and entorhinal cortex
<p>This dataset contains iEEG neural recordings and behavior movement direction in a navigation task from human subjects undergoing inpatient monitoring for seizure localization. The experimental design, including an explanation of metrics of interest, is detailed in Chen et al (2018) <em>Current Biology</em> and Chen et al (2021) <em>Science Advances</em>. EXAMPLE electrode data from the vmPFC and EC ROIs are included. These data are used for grid-like modulation of theta power in vmPFC and EC.</p>
Theta dominates cross-frequency coupling in hippocampal-medial entorhinal circuit during awake-behavior in rats
<p>Hippocampal theta and gamma rhythms are hypothesized to play a role in the physiology of higher cognition. Prior research has reported that an offset in theta cycles between the entorhinal cortex, CA3, and CA1 regions promotes independence of population activity across the hippocampus. In line with this idea, it has recently been observed that CA1 pyramidal cells can establish and maintain coordinated place cell activity intrinsically, with minimal reliance on afferent input. Counter to these observations is the contemporary hypothesis that CA1 neuron activity is driven by a gamma oscillation arising from the medial entorhinal cortex (MEC) that relays information by providing precisely timed synchrony between MEC and CA1. Reinvestigating this in rats during appetitive track running, we found that theta is the dominant frequency of cross-frequency coupling between the MEC and hippocampus, with hippocampal gamma largely independent of entorhinal gamma.</p>
Denervated mouse CA1 pyramidal neurons express homeostatic synaptic plasticity following entorhinal cortex lesion
<p><span>Structural, functional, and molecular reorganization of denervated neural networks is often observed in neurological conditions. The loss of input is accompanied by homeostatic synaptic adaptations, which can affect the reorganization process. A major challenge of denervation-induced homeostatic plasticity operating in complex neural networks is the specialization of neuronal inputs. It remains unclear whether neurons respond similarly to the loss of distinct inputs. Here, we used <em>in</em> <em>vitro</em> entorhinal cortex lesion (ECL) and Schaffer collateral lesion (SCL) in mouse organotypic entorhino-hippocampal tissue cultures to study denervation-induced plasticity of CA1 pyramidal neurons. We observed microglia accumulation, presynaptic bouton degeneration, and a reduction in dendritic spine numbers in the denervated layers three days after SCL and ECL. Transcriptome analysis of the CA1 region revealed complex changes in differential gene expression following SCL and ECL compared to non-lesioned controls with a specific enrichment of differentially expressed synapse-related genes observed after ECL. Consistent with this finding, denervation-induced homeostatic plasticity of excitatory synapses was observed three days after ECL but not after SCL. Chemogenetic silencing of the EC but not CA3 confirmed the pathway-specific induction of homeostatic synaptic plasticity in CA1. Additionally, increased RNA oxidation was observed after SCL and ECL. These results reveal important commonalities and differences between distinct pathway lesions and demonstrate a pathway-specific induction of denervation-induced homeostatic synaptic plasticity. </span></p>
An entorhinal-like region in food-caching birds
<p>The mammalian entorhinal cortex routes inputs from diverse sources into the hippocampus. This information is mixed and expressed in the activity of many specialized entorhinal cell types, which are considered indispensable for hippocampal function. However, functionally similar hippocampi exist even in non-mammals that lack an obvious entorhinal cortex, or generally any layered cortex. To address this dilemma, we mapped extrinsic hippocampal connections in chickadees, whose hippocampi are used for remembering numerous food caches. We found a well-delineated structure in these birds that is topologically similar to the entorhinal cortex and interfaces between the hippocampus and other pallial regions. Recordings of this structure revealed entorhinal-like activity, including border and multi-field grid-like cells. These cells were localized to the subregion predicted by anatomical mapping to match the dorsomedial entorhinal cortex. Our findings uncover an anatomical and physiological equivalence of vastly different brains, suggesting a fundamental nature of entorhinal-like computations for hippocampal function.</p>
The Entorhinal Cortex and Aerobic Exercise in Aging
ClinicalTrials.gov study NCT02775760. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: ASHS-OAP atlas for automatic entorhinal cortex segmentation
Open the record for dataset details and reuse information.
Theta dominates cross-frequency coupling in hippocampal-medial entorhinal circuit during awake-behavior in rats
Open the record for dataset details and reuse information.
Theta oscillations coordinate grid-like representations between ventromedial prefrontal and entorhinal cortex
Open the record for dataset details and reuse information.
Denervated mouse CA1 pyramidal neurons express homeostatic synaptic plasticity following entorhinal cortex lesion
Open the record for dataset details and reuse information.
An entorhinal-like region in food-caching birds
Open the record for dataset details and reuse information.
Entorhinal-retrosplenial circuits for allocentric-egocentric transformation of boundary coding
<p>Spatial navigation requires landmark coding from two perspectives, relying on viewpoint-invariant and self-referenced representations. The brain encodes information within each reference frame, but their interactions and functional dependency remains unclear. Here we investigate the relationship between neurons in rat retrosplenial cortex (RSC) and entorhinal cortex (MEC) that increase firing near boundaries of space. Border cells in RSC specifically encode walls, but not objects, and are sensitive to the animal's direction to nearby borders. These egocentric representations are generated independent of visual or whisker sensation, but depend on inputs from MEC that contains allocentric spatial cells. Pharmaco- and optogenetic inhibition of MEC cells led to a disruption of border coding in RSC, but not vice versa, indicating allocentric-to-egocentric transformation. Finally, RSC border cells fire prospective to the animal's next motion, unlike those in MEC, revealing the MEC-RSC pathway as an extended border coding circuit that implements coordinate transformation to guide navigation behavior.</p>
Entorhinal-retrosplenial circuits for allocentric-egocentric transformation of boundary coding
Open the record for dataset details and reuse information.
Data from: Visual landmarks sharpen grid cell metric and confer context specificity to neurons of the medial entorhinal cortex
Neurons of the medial entorhinal cortex (MEC) provide spatial representations critical for navigation. In this network, the periodic firing fields of grid cells act as a metric element for position. The location of the grid firing fields depends on interactions between self-motion information, geometrical properties of the environment and nonmetric contextual cues. Here, we test whether visual information, including nonmetric contextual cues, also regulates the firing rate of MEC neurons. Removal of visual landmarks caused a profound impairment in grid cell periodicity. Moreover, the speed code of MEC neurons changed in darkness and the activity of border cells became less confined to environmental boundaries. Half of the MEC neurons changed their firing rate in darkness. Manipulations of nonmetric visual cues that left the boundaries of a 1D environment in place caused rate changes in grid cells. These findings reveal context specificity in the rate code of MEC neurons.
Data from: Visual landmarks sharpen grid cell metric and confer context specificity to neurons of the medial entorhinal cortex
Open the record for dataset details and reuse information.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.