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Dataset results
222 results for “epithelial infection”
Time-lapse 3D confocal microscopy videos of mitochondrial dynamics in human alveolar epithelial cells (A549-DsRed) infected with Mycobacterium marinum (Mmar) strains
<div>The dataset consists of time-lapse, 3D confocal images of mitochondrial dynamics in human alveolar epithelial cells (A549-DsRed) infected with Mycobacterium marinum (Mmar) strains. Images were captured at 60X magnification in an environmental chamber at 35°C for live-cell imaging. Host cell mitochondria were labeled with red fluorescent protein (RFP) and infected with both wildtype (wt) and ESAT-6 operon knockout mutant labeled with green fluorescent protein (GFP) at MOI of 100 for 24 hours at 35°C. Infected cells were identified and analyzed to explore the effect of pathogenic mycobacteria on mitochondrial morphology over time.</div> <div> </div> <div>More details available in this preprint: <a href="https://doi.org/10.48550/arXiv.2411.06035">https://doi.org/10.48550/arXiv.2411.06035</a></div>
Dataset - A lung-on-chip model reveals an essential role for alveolar epithelial cells in controlling bacterial growth during early M. tuberculosis infection
<p>Description of the sub-folders<br> Name, type of data, corresponding Figure in the manuscript<br> 3D view of the LoC model - .tiff image stack, Figure 1.</p> <p>Bacterial Growth Rate Data - .tiff image stacks, .csv files and MATLAB code to extract the fluorescence intensity over time, Figure 2, Figure 2 - figure supplement 2, Figure 2 - figure supplement 4, Figure 3, Figure 3 - figure supplement 2, Figure 4.</p> <p>AT Characterization - .tiff image stacks and MATLAB code to extract the number and volume of lamellar bodies from the stack of confocal images, Figure 1, Figure 1 - figure supplement 1, Figue 1 - figure supplement 2.</p> <p>AT Infection in LoC model - .tiff image stacks, Figure 2 - figure supplement 1.</p> <p>AT Infection in vivo - .tiff image stacks, Figure 1 - figure supplement 3.</p> <p>Simulations of in vivo infections - .dat files of growth rates in macrophages for the WT and ESX-1 deficient populations and MATLAB code to simulate an infection from this data, Figure 4.</p> <p> </p>
Cultured renal proximal tubular epithelial cells resemble stressed/damaged kidney while supporting BKV infection
<p>Supplementary tables for the manuscript: Cultured renal proximal tubular epithelial cells resemble stressed/damaged kidney while supporting BKV infection</p> <p>The scRNA-Seq of RPTE and hTERT-RPTE cells infected by BKV (10X Genomics) is available under NCBI Bioproject PRJNA961060 (https://www.ncbi.nlm.nih.gov/bioproject/PRJNA961060)</p> <p> </p> <p> </p> <p> </p>
Data from: Dynamics of the CD9 interactome during bacterial infection of epithelial cells by proximity labelling proteomics
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Unravelling the metabolic alterations induced by Zika infection in prostate epithelial (PNT1a) and adenocarcinoma (PC-3) cell lines
<p>Unravelling the metabolic alterations induced by Zika infection in prostate epithelial (PNT1a) and adenocarcinoma (PC-3) cell lines</p>
RNA sequencing of sorted conducting airway epithelial cells from FGF9-overexpressing and control mouse lungs at 1 day post-infection with IAV
<p><span>Influenza A virus (IAV) preferentially infects conducting airway and alveolar epithelial cells in the lung. The outcome of these infections is impacted by the host response, including the production of various cytokines, chemokines, and growth factors. Fibroblast growth factor-9 (FGF9) is required for lung development, can display antiviral activity <em>in vitro</em>, and is upregulated in asymptomatic patients during early IAV infection. We therefore hypothesized that FGF9 would protect the lungs from respiratory virus infection and evaluated IAV pathogenesis in mice that overexpress FGF9 in club cells in the conducting airway epithelium (FGF9-OE mice). However, we found that FGF9-OE mice were highly susceptible to IAV and Sendai virus infection compared to control mice. FGF9-OE mice displayed elevated and persistent viral loads, increased expression of cytokines and chemokines, and increased numbers of infiltrating immune cells as early as 1 day post-infection (dpi). Gene expression analysis showed an elevated type I interferon (IFN) signature in the conducting airway epithelium and analysis of IAV tropism uncovered a dramatic shift in infection from the conducting airway epithelium to the alveolar epithelium in FGF9-OE lungs. These results demonstrate that FGF9 signaling primes the conducting airway epithelium to rapidly induce a localized, protective IFN and proinflammatory cytokine response during viral infection. Although this response protects the airway epithelial cells from IAV infection, it allows for early and enhanced infection of the alveolar epithelium, ultimately leading to increased morbidity and mortality. Our study illuminates a novel role for FGF9 in regulating respiratory virus infection and pathogenesis.</span></p>
RNA sequencing of sorted conducting airway epithelial cells from FGF9-overexpressing and control mouse lungs at 1 day post-infection with IAV
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Transcriptome analysis of Intestinal epithelial cells after Heligmosomoides polygyrus bakeri (Hpb) infection
GEO Series GSE200775. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Elderly lung mucosa impact on Mycobacterium tuberculosis adaptation during infection of alveolar epithelial cells
GEO Series GSE244851. Mycobacterium tuberculosis. 14 samples. Type: Expression profiling by high throughput sequencing.
Expression data from Influenza A infected mouse primary tracheal epithelial cell cultures (MTEC), from wild-type, IFNAR1-/-, IL28Ra-/- and IFNAR1-/- IL28Ra-/- double ko
GEO Series GSE43708. Mus musculus. 40 samples. Type: Expression profiling by array.
Limited response of primary nasal epithelial cells to Bordetella pertussis infection [RNAseq_Sort_population]
GEO Series GSE302040. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Chromatin accessibility dynamics of Chlamydia-infected epithelial cells
GEO Series GSE132448. Homo sapiens. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Differences between the global transcriptomes of Salmonella enterica serovars Dublin and Cerro during infection of bovine epithelial cells
GEO Series GSE182165. Salmonella enterica. 12 samples. Type: Expression profiling by high throughput sequencing.
Expression data from Influenza A infected mouse primary tracheal epithelial cell cultures (MTEC)
GEO Series GSE43707. Mus musculus. 10 samples. Type: Expression profiling by array.
Single-cell atlas of patient-derived cervical organoids uncovers epithelial immune heterogeneity and intercellular crosstalk during Chlamydia infection
GEO Series GSE231773. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Effect of miR-144/miR451 expression on TC-1 lung epithelial cell responses to influenza infection for 24 hours [RT-PCR]
GEO Series GSE31956. Mus musculus. 2 samples. Type: Other.
Host gene expression analysis in oral epithelial cells upon KSHV infection
GEO Series GSE223396. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Human Nasal Epithelial Cells sustain persistent SARS-CoV-2 infection in vitro, despite eliciting a prolonged antiviral response.
GEO Series GSE182475. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Infection of human Nasal Epithelial Cells with SARS-CoV-2 and a 382-nt deletion isolate lacking ORF8 reveals similar viral kinetics and host transcriptional profiles
GEO Series GSE162131. Homo sapiens. 21 samples. Type: Expression profiling by high throughput sequencing.
Effect of Dhps deletion in epithelial cells and Citrobacter rodentium infection on the transcriptome of the colonic mucosa
GEO Series GSE262899. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.