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ShareScore release 0.9.0
Dataset results
50 results for “established infection”
Early ART to Limit Infection and Establishment of Reservoir
ClinicalTrials.gov study NCT02859558. IPD Sharing: YES. Countries: 6. Publications: 1.
Comparative analysis of helminth infectivity: growth in intermediate hosts increases establishment rates in the next host
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Data from: The stochastic dynamics of early epidemics: probability of establishment, initial growth rate, and infection cluster size at first detection
<p>Emerging epidemics and local infection clusters are initially prone to stochastic effects that can substantially impact the epidemic trajectory. While numerous studies are devoted to the deterministic regime of an established epidemic, mathematical descriptions of the initial phase of epidemic growth are comparatively rarer. Here, we review existing mathematical results on the epidemic size over time, and derive new results to elucidate the early dynamics of an infection cluster started by a single infected individual. We show that the initial growth of epidemics that eventually take off is accelerated by stochasticity. These results are critical to improve early cluster detection and control. As an application, we compute the distribution of the first detection time of an infected individual in an infection cluster depending on the testing effort, and estimate that the SARS-CoV-2 variant of concern Alpha detected in September 2020 first appeared in the United Kingdom early August 2020. We also compute a minimal testing frequency to detect clusters before they exceed a given threshold size. These results improve our theoretical understanding of early epidemics and will be useful for the study and control of local infectious disease clusters.</p>
Natural history and ecological effects on the establishment and fate of Florida carpenter ant cadavers infected by the parasitic-manipulator Ophiocordyceps camponoti-floridani
<p class="MsoNormal">1. <em>Ophiocordyceps</em> fungi manipulate the behavior of their ant hosts to produce a summit disease phenotype, thereby establishing infected ant cadavers onto vegetation at elevated positions suitable for fungal growth and transmission. Multiple environmental and ecological factors have been proposed to shape the timing, positioning, and outcome of these manipulations.</p> <p class="MsoNormal">2. We conducted a long-term field study of <em>Ophiocordyceps</em> <em>camponoti-floridani</em> infections of <em>Camponotus floridanus</em> ants – the Florida zombie ants. We propose and refine hypotheses on the factors that shape infection outcomes by tracking the occurrence of fungal growth from hundreds of ant cadavers. We modeled and report these data in relation to weather, light, vegetation, and attack by mycoparasites.</p> <p class="MsoNormal">3. We investigated environmental factors that could affect the occurrence and location of newly manipulated ant cadavers. New cadavers were positively correlated with epiphytic <em>Tillandsia </em>bromeliads, canopy openness, and weather conditions (an interactive effect of temperature, humidity, and precipitation) with an increased occurrence during the sub-tropical summer. We further suggest that incident light at the individual cadaver level may reflect microhabitat choice by manipulated ants or selective pressure on cadaver maintenance for conditions improving fungal survival.</p> <p class="MsoNormal">4. We also sought to connect fungal fitness to environmental conditions. Continued fungal development of reproductive structures and putative transmission increased with moist weather conditions (interaction of humidity and precipitation) and canopy openness, while being reduced by attack by mycoparasites. Moreover, under the most open canopy conditions, we found an atypical <em>Ophiocordyceps</em> growth morphology that could represent a plastic response to conditions influenced by high light levels.</p> <p class="MsoNormal">5. Taken together, we explore general trends and the effects of various ecological conditions on host and parasite disease outcomes in the Florida zombie ant system. These insights from the field can be used to inform experimental laboratory setups that directly test the effects of biotic and abiotic factors on fungus-ant interactions or aim to uncover underlying molecular mechanisms.</p>
Establishing a Controlled Human Infection Model of Bordetella Pertussis
ClinicalTrials.gov study NCT05136599. IPD Sharing: NO. Countries: 1. Publications: 0.
Natural history and ecological effects on the establishment and fate of Florida carpenter ant cadavers infected by the parasitic-manipulator Ophiocordyceps camponoti-floridani
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Data from: The stochastic dynamics of early epidemics: probability of establishment, initial growth rate, and infection cluster size at first detection
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Establishing a Controlled Human Hookworm Infection Model at Leiden University Medical Center
ClinicalTrials.gov study NCT03126552. IPD Sharing: NO. Countries: 1. Publications: 1.
Establish and Characterize an Acute HIV Infection Cohort in a High Risk Population
ClinicalTrials.gov study NCT00796146. IPD Sharing: Not stated. Countries: 1. Publications: 9.
Establishment of Prevention and Control System of Central Nervous System Infection
ClinicalTrials.gov study NCT04722328. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: Existing infection facilitates establishment and density of malaria parasites in their mosquito vector
Very little is known about how vector-borne pathogens interact within their vector and how this impacts transmission. Here we show that mosquitoes can accumulate mixed strain malaria infections after feeding on multiple hosts. We found that parasites have a greater chance of establishing and reach higher densities if another strain is already present in a mosquito. Mixed infections contained more parasites but these larger populations did not have a detectable impact on vector survival. Together these results suggest that mosquitoes taking multiple infective bites may disproportionally contribute to malaria transmission. This will increase rates of mixed infections in vertebrate hosts, with implications for the evolution of parasite virulence and the spread of drug-resistant strains. Moreover, control measures that reduce parasite prevalence in vertebrate hosts will reduce the likelihood of mosquitoes taking multiple infective feeds, and thus disproportionally reduce transmission. More generally, our study shows that the types of strain interactions detected in vertebrate hosts cannot necessarily be extrapolated to vectors.
Duvelisib Ameliorates Manifestations of Pneumonia in Established Novel Coronavirus Infection (COVID-19)
ClinicalTrials.gov study NCT04487886. IPD Sharing: YES. Countries: 1. Publications: 0.
Data from: Existing infection facilitates establishment and density of malaria parasites in their mosquito vector
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Establishment of a mandible defect model in rabbits infected with multiple bacteria and bioinformatics analysis
GEO Series GSE248915. Oryctolagus cuniculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic analysis genes involved in the establishment and maintenance of FMDV persistent infection
GEO Series GSE93045. Mesocricetus auratus. 9 samples. Type: Expression profiling by high throughput sequencing.
Circulating NK cells establish tissue-residency upon acute infection of skin and mediate accelerated effector responses to secondary infection
GEO Series GSE227801. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Circulating NK cells establish tissue-residency upon acute infection of skin and mediate accelerated effector responses to secondary infection
GEO Series GSE226756. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing; Other.
Early precursor T cells establish and propagate T cell exhaustion in chronic infection [ATAC-seq]
GEO Series GSE142575. Mus musculus. 16 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Parvovirus Minute Virus of Mice Localizes to Sites of Cellular DNA Damage to Establish and Amplify its Lytic Infection
GEO Series GSE112957. Mus musculus. 23 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other.
PD-1+ Tcf1+ CD8+ T cells from established chronic infections can convert into memory cells but keep a stable imprint of persistent stimulation
GEO Series GSE153376. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.