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654 results for “estrogen receptor”
Dataset for FigS2F in "DNA is the allosteric driver for the asymmetric binding of homodimer estrogen-related receptor"
<p><strong>Abstract</strong></p> <p>The estrogen-related receptors (ERRs, NR3B), orphan members of the steroid hormone receptor (SR) subfamily (NR3), are crucial for the transcriptional control of cellular energy metabolism. As basal members of NR3 subfamily, the ERRs are key elements for the understanding of how the binding of SRs to DNA evolved from monomeric to dimeric palindromic binding sites. To unravel the initial steps of DNA selection by SRs, we combined structural, biophysical and phylogenetic studies. Our results unveil the molecular mechanisms of the ERR dimerization which are imprinted in the protein itself with DNA acting as an allosteric driver by allowing the formation of a novel extended asymmetric dimerization region (KR-box). Phylogenetic analyses suggest that the dimerization asymmetry used by ERRs is an ancestral feature necessary for establishing a strong overall dimerization interface, which was progressively lost in the course evolution by other SRs.</p> <p><strong>Methods</strong></p> <p>Ancestral character reconstruction and stochastic mapping were performed under R version 4.1.2 using the make.simmap function as implemented in the phytools package version 1.0-1. Character evolution was inferred using a model of symmetrical transition rates between the character states (SYM). 10 000 character histories were sampled to allow the incorporation of the uncertainty associated with the transition between different states. Inferred state frequencies for ancestral nodes were plotted using the describe.simmap function.</p> <p><strong>Usage Notes</strong></p> <p>This dataset contains all the files necessary to reproduce Figure S2 of the associated paper (Patel et al., in preparation). Those files are:</p> <p>- script_FigS2F.R : the R script necessary to load the data and process them as indicated in the methods section. The outputs of character mappings are also indicated in the script file, in order that the user can compare them with the results he would get on his/her own computer.</p> <p>- tree_FigS2F.nex: the backbone tree used for character mapping</p> <p>- FigS2F_KR_box.csv: the data table containing the presence-absence data regarding the KR box motif for each nuclear receptor.</p>
Training data for ChIP-seq data analysis (Galaxy Training Material): Identification of the binding sites of the Estrogen receptor
<p>The data provided here are part of a Galaxy Training Network tutorial that analyzes ChIP-seq data from a study published by Ross-Inness et al., 2012 (DOI:10.1038/nature10730) to identify the binding sites of the Estrogen receptor, a transcription factor known to be associated with different types of breast cancer.</p>
Safety and Efficacy Study of Sapanisertib in Combination With Exemestane or Fulvestrant in Postmenopausal Women With Estrogen Receptor Positive/Human Epidermal Growth Factor Receptor 2 Negative (ER+/H
ClinicalTrials.gov study NCT02049957. IPD Sharing: YES. Countries: 3. Publications: 1.
A Study of Everolimus Plus Exemestane in Chinese Postmenopausal Women With Estrogen Receptor Positive, Locally Advanced, Recurrent, or Metastatic Breast Cancer After Recurrence or Progression on Non-s
ClinicalTrials.gov study NCT03312738. IPD Sharing: YES. Countries: 1. Publications: 1.
Selective Estrogen Receptor Modulators to Enhance the Efficacy of Viral Reactivation With Histone Deacetylase Inhibitors
ClinicalTrials.gov study NCT03382834. IPD Sharing: YES. Countries: 2. Publications: 1.
Phase 1/2 Study of Amcenestrant (SAR439859) Single Agent and in Combination With Other Anti-cancer Therapies in Postmenopausal Women With Estrogen Receptor Positive Advanced Breast Cancer
ClinicalTrials.gov study NCT03284957. IPD Sharing: YES. Countries: 10. Publications: 1.
A Study Evaluating the Efficacy and Safety of Giredestrant Compared With Physician's Choice of Endocrine Monotherapy in Participants With Previously Treated Estrogen Receptor-Positive, HER2-Negative L
ClinicalTrials.gov study NCT04576455. IPD Sharing: YES. Countries: 17. Publications: 2.
BI 836845 in Estrogen Receptor Positive Metastatic Breast Cancer
ClinicalTrials.gov study NCT02123823. IPD Sharing: YES. Countries: 10. Publications: 2.
Zoledronic Acid - Letrozole Adjuvant Synergy Trial (ZFAST) - Cancer Treatment Related Bone Loss in Postmenopausal Women With Estrogen Receptor Positive and/or Progesterone Receptor Positive Breast Can
ClinicalTrials.gov study NCT00050011. IPD Sharing: Not stated. Countries: 2. Publications: 1.
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Giredestrant Plus Palbociclib Compared With Anastrozole Plus Palbociclib for Postmenopausal Women With Estrogen Receptor-Positive and
ClinicalTrials.gov study NCT04436744. IPD Sharing: YES. Countries: 11. Publications: 1.
A Study of H3B-6545 in Combination With Palbociclib in Women With Advanced or Metastatic Estrogen Receptor-Positive Human Epidermal Growth Factor Receptor-2 (HER2)-Negative Breast Cancer
ClinicalTrials.gov study NCT04288089. IPD Sharing: YES. Countries: 2. Publications: 1.
Pembrolizumab and Doxorubicin Hydrochloride or Anti-Estrogen Therapy in Treating Patients With Triple-Negative or Hormone Receptor-Positive Metastatic Breast Cancer
ClinicalTrials.gov study NCT02648477. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study of Nivolumab Versus Placebo in Combination With Neoadjuvant Chemotherapy and Adjuvant Endocrine Therapy in Participants With High-risk, Estrogen Receptor-Positive (ER+), Human Epidermal Growth F
ClinicalTrials.gov study NCT04109066. IPD Sharing: Not stated. Countries: 32. Publications: 2.
A Study of Abiraterone Acetate Plus Prednisone With or Without Exemestane in Postmenopausal Women With Estrogen Receptor-Positive (ER+) Metastatic Breast Cancer Progressing After Letrozole or Anastroz
ClinicalTrials.gov study NCT01381874. IPD Sharing: Not stated. Countries: 12. Publications: 1.
A Study of GDC-0810 Single Agent or in Combination With Palbociclib and/or a Luteinizing Hormone-Releasing Hormone (LHRH) Agonist in Women With Locally Advanced or Metastatic Estrogen Receptor Positiv
ClinicalTrials.gov study NCT01823835. IPD Sharing: Not stated. Countries: 4. Publications: 1.
Cetuximab and Cisplatin in the Treatment of "Triple Negative" (Estrogen Receptor [ER] Negative, Progesterone Receptor [PgR] Negative, and Human Epidermal Growth Factor Receptor 2 [HER2] Negative) Meta
ClinicalTrials.gov study NCT00463788. IPD Sharing: Not stated. Countries: 11. Publications: 1.
Palbociclib and Letrozole or Fulvestrant in Treating Patients With Estrogen Receptor Positive, HER2 Negative Metastatic Breast Cancer
ClinicalTrials.gov study NCT03633331. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Two Different Schedules of Palbociclib + Second Line Endocrine Therapy in Estrogen Receptor Positive, HER2 Neg Advanced/Metastatic Breast Cancer
ClinicalTrials.gov study NCT02630693. IPD Sharing: YES. Countries: 1. Publications: 1.
Estrogen Receptor Antagonist in Patients With Pulmonary Arterial Hypertension
ClinicalTrials.gov study NCT02911844. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Trial of H3B-6545, in Women With Locally Advanced or Metastatic Estrogen Receptor-positive, HER2 Negative Breast Cancer
ClinicalTrials.gov study NCT03250676. IPD Sharing: Not stated. Countries: 3. Publications: 1.
ScienceDex guides
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