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90 results for “expression stability”
A pharmacological chaperone stabilizer rescues the expression of the vast majority of pathogenic variants in a G protein-coupled receptor
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Data from: HDAC1/2-dependent P0 expression maintains paranodal and nodal integrity independently of myelin stability through interactions with neurofascins
The pathogenesis of peripheral neuropathies in adults is linked to maintenance mechanisms that are not well understood. Here, we elucidate a novel critical maintenance mechanism for Schwann cell (SC)–axon interaction. Using mouse genetics, ablation of the transcriptional regulators histone deacetylases 1 and 2 (HDAC1/2) in adult SCs severely affected paranodal and nodal integrity and led to demyelination/remyelination. Expression levels of the HDAC1/2 target gene myelin protein zero (P0) were reduced by half, accompanied by altered localization and stability of neurofascin (NFasc)155, NFasc186, and loss of Caspr and septate-like junctions. We identify P0 as a novel binding partner of NFasc155 and NFasc186, both in vivo and by in vitro adhesion assay. Furthermore, we demonstrate that HDAC1/2-dependent P0 expression is crucial for the maintenance of paranodal/nodal integrity and axonal function through interaction of P0 with neurofascins. In addition, we show that the latter mechanism is impaired by some P0 mutations that lead to late onset Charcot-Marie-Tooth disease.
Data from: The expression of established cognitive brain states stabilizes with working memory development
We present results from a longitudinal study conducted over 10 years in a sample of 126 8-33 year olds demonstrating that adolescent development of working memory is supported by decreased variability in the amplitude of expression of whole brain states of task-related activity. fMRI analyses reveal that putative gain signals affecting maintenance and retrieval aspects of working memory processing stabilize during adolescence, while those affecting sensorimotor processes do not. We show that trial-to-trial variability in the reaction time and accuracy of eye-movements during a memory guided saccade task are related to fluctuations in the amplitude of expression of task-related brain states, or brain state variability, and also provide evidence that individual developmental trajectories of reaction time variability are related to individual trajectories of brain state variability. These observations demonstrate that underlying the maturation of cognition through adolescence is the stabilization of widespread gain signals affecting already available cognitive processes.
Data from: The expression of established cognitive brain states stabilizes with working memory development
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Data from: HDAC1/2-dependent P0 expression maintains paranodal and nodal integrity independently of myelin stability through interactions with neurofascins
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Low RNA stability signifies strong expression regulatability of tumor suppressors
GEO Series GSE197495. Homo sapiens. 44 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
Gene expression analysis of prostate tumors arisen in TRAMP mice in which mast cells are pharmacologically stabilized or genetically ablated.
GEO Series GSE29956. Mus musculus. 8 samples. Type: Expression profiling by array.
Serum response factor reduces gene expression noise and confers cell state stability
GEO Series GSE210074. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance [RNA-seq II]
GEO Series GSE152849. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
YY1 stabilizes super enhancer-promoter loops and gene expression during mesenchymal stem cell aging (RNA-Seq)
GEO Series GSE261010. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Contact inhibition controls miR-223 stabilization via p27kip1 expression
GEO Series GSE45538. Homo sapiens; Mus musculus. 16 samples. Type: Non-coding RNA profiling by array.
Genome-wide transcriptional silencing and mRNA stabilization allow the coordinated expression of the meiotic program in mice
GEO Series GSE261062. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Alloantigen-Induced Regulatory T Cells Generated in Presence of Vitamin C Display Enhanced Stability of Foxp3 Expression and Promote Skin Allograft Acceptance
GEO Series GSE96960. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
RORγt expression in mature Th17 cells safeguard the lineage stability by inhibiting conversion to Th2 cells [RNA-Seq]
GEO Series GSE190538. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Stability of gene expression and epigenetic profiles highlights the utility of patient-derived paediatric acute lymphoblastic leukaemia xenografts for investigatoing molecular mechanisms of drug resis
GEO Series GSE57491. Homo sapiens. 18 samples. Type: Expression profiling by array.
Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance [scRNAseq]
GEO Series GSE154143. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Gene Expression Profiling of Whole Blood: A Comparative Assessment of RNA-Stabilizing Collection Methods
GEO Series GSE103889. Homo sapiens. 64 samples. Type: Expression profiling by array.
YY1 stabilizes super enhancer-promoter loops and gene expression during mesenchymal stem cell aging (ChIP-Seq)
GEO Series GSE261008. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
KIAA1429/VIRMA promotes breast cancer proliferation and migration by stabilizing m6A-modified HAS2 RNA expression in cytosol
GEO Series GSE185494. Homo sapiens. 13 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
mRNA stability fine tunes gene expression in the developing cortex to control neurogenesis [RNA-Seq]
GEO Series GSE281690. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.