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78 results for “fat content”
A Study to Investigate Effects of Omega-3 Carboxylic Acids and Dapagliflozin on Liver Fat Content in Diabetic Patients
ClinicalTrials.gov study NCT02279407. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect Of Exenatide Treatment on Liver Fat Content in Patients With Diabetes
ClinicalTrials.gov study NCT01432405. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Measure Liver Fat Content After ISIS 301012 (Mipomersen) Administration
ClinicalTrials.gov study NCT00362180. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effect Of NS-0200 Versus Placebo On Hepatic Fat Content In Patients With Non Alcoholic Fatty Liver Disease
ClinicalTrials.gov study NCT02546609. IPD Sharing: NO. Countries: 1. Publications: 2.
A Study of Oral Insulin to Reduce Liver Fat Content in Type 2 Diabetes Patients With Nonalcoholic Steatohepatitis (NASH)
ClinicalTrials.gov study NCT04616014. IPD Sharing: NO. Countries: 1. Publications: 3.
Data from: A functional regulatory variant of MYH3 influences muscle fiber-type composition and intramuscular fat content in pigs
Muscle development and lipid accumulation in muscle critically affect meat quality in livestock. Yet, the underlying genetic factors for myofiber-type specification and intramuscular fat (IMF) accumulation remain to be elucidated. Using two independent intercrosses between Western breeds and Korean native pigs (KNPs) and a joint linkage-linkage disequilibrium analysis, we here identified a 488.1-kb region on porcine chromosome 12 that affects both reddish meat color (a*) and IMF. In this critical region, only the MYH3 gene, encoding myosin heavy chain 3, was found to be preferentially overexpressed in the skeletal muscle in KNPs. Subsequently, MYH3-transgenic mice demonstrated that this gene controls both myofiber-type specification and adipogenesis in skeletal muscle. We discovered a structural variant in the promotor/regulatory region of MYH3 for which Q allele carriers exhibited significantly higher values of a* and IMF than q allele carriers. Furthermore, chromatin immunoprecipitation and co-transfection assays showed the structural variant in the 5'-UTR of MYH3 abrogated binding of the myogenic regulatory factors (MYF5, MYOD, MYOG, and MRF4). The allele distribution of the MYH3 among worldwide pig populations indicated that the MYH3 Q allele is of Asian origin and likely predates domestication. In conclusion, we identified a functional regulatory sequence variant in the porcine MYH3 that provides novel insights into the genetic basis of the regulation of myofiber type ratios and associated changes in IMF in pigs. The MYH3 variant can play an important role to improve pork quality in current breeding programs.
Determination of solid fat content in emulsions using TD-NMR FID-CPMG deconvolution
<p>Determination of solid fat content in emulsions using TD-NMR FID-CPMG deconvolution</p>
Enhancing cardiac glycolysis causes an increase in PDK4 content in response to short term high fat diet
<p>Cardiac metabolic flexibility is essential for proper function. Under pathological conditions, such as diabetes, the heart increases reliance on fatty acid oxidation at the expense of glucose metabolism. Thus, restoring or enhancing glucose usage may provide a therapeutic strategy. In this study we sought to identify how the cardiac proteomic profile is affected basally and after a short term high fat diet (7d) in wild type and a transgenic model of enhanced glycolysis (Glyco<sup>Hi</sup>). Targeted quantitative proteomics and cluster analysis revealed revealed Glyco<sup>Hi</sup> mice have increased protein expression of glycolytic enzymes and that this was sustained with the high fat diet challenge. Glyco<sup>Hi</sup> mice also had significantly increased expression of pyruvate dehydrogenase kinase 4 (PDK4), an enzyme that regulates the overall rate of glucose oxidation. These results support that Glyco<sup>Hi</sup> mice have the capacity to increase glycolysis when challenged with a nutrient stress but that there is a compensatory increase in PDK4 that may limit the overall rate of glucose oxidation.</p>
Importance of Meal Fat Content and Gall Bladder Emptying for Postprandial GLP-1 Secretion in Type 2 Diabetes Patients
ClinicalTrials.gov study NCT01374594. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Effects of Overfeeding Followed by Weight Loss on Liver Fat Content and Adipose Tissue Inflammation
ClinicalTrials.gov study NCT02133144. IPD Sharing: Not stated. Countries: 1. Publications: 3.
The Role of Dietary Carbohydrate and Fat Availability in the Regulation of Hepatic Lipid Content
ClinicalTrials.gov study NCT04581421. IPD Sharing: Not stated. Countries: 1. Publications: 1.
MRI to Measure Liver Fat Content
ClinicalTrials.gov study NCT00594412. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Rebalancing the Fat Content of the Heart and Muscles
ClinicalTrials.gov study NCT07065383. IPD Sharing: NO. Countries: 0. Publications: 25.
The Effects of PXR Activation on Hepatic Fat Content
ClinicalTrials.gov study NCT02329405. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A 24 Week, Multicenter, Prospective, Open-labeled, Single-arm, Exploratory Phase 4 Clinical Trial to Evaluate the Safety and Efficacy of Lobeglitazone in Decreasing Intrahepatic Fat Contents in Type 2
ClinicalTrials.gov study NCT02285205. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effect of Dietary Fat Content on the Recurrence of Pancreatitis
ClinicalTrials.gov study NCT04761523. IPD Sharing: NO. Countries: 1. Publications: 26.
Study on Liver Fat Content and Visceral Fat Mass in Overweight and Obese Type 2 Diabetes Patients After Treatment With Basal Insulin
ClinicalTrials.gov study NCT01310452. IPD Sharing: Not stated. Countries: 1. Publications: 10.
Exenatide Compared With Insulin Glargine to Change Liver Fat Content in Type 2 Diabetes
ClinicalTrials.gov study NCT02303730. IPD Sharing: NO. Countries: 1. Publications: 11.
What is the Dose Response of Varying Meal Content of Fat on Postprandial Glycaemia in Children With T1DM?
ClinicalTrials.gov study NCT02371694. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Effects of Milk Fat Globule Membrane (MFGM) - Enriched Formula With Reduced Energy and Protein Content on Growth and Development
ClinicalTrials.gov study NCT00624689. IPD Sharing: Not stated. Countries: 1. Publications: 2.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.