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171 results for “fatty acid oxidation”
Metadata of the study HMGCR activity is essential for mitochondrial β-oxidation of fatty acids to prevent lethal accumulation of long-chain acylcarnitines in the mouse liver
<p>Metadata of the study "HMGCR activity is essential for mitochondrial β-oxidation of fatty acids to prevent lethal accumulation of long-chain acylcarnitines in the mouse liver" published in Br J Pharmacol 2024. Apr 19. doi: 10.1111/bph.16363.</p>
Supplementary data to publication "Abomasal infusion of essential fatty acids and conjugated linoleic acid during late pregnancy and early lactation affects immunohematological and oxidative stress markers in dairy cows"
<p>Supplementary data to publication "Abomasal infusion of essential fatty acids and conjugated linoleic acid during late pregnancy and early lactation affects immunohematological and oxidative stress markers in dairy cows" in Journal of Dairy Science; DOI: <a href="https://doi.org/10.3168/jds.2022-22514">https://doi.org/10.3168/jds.2022-22514</a></p>
Long-Chain Fatty Acid Oxidation Disorders (LC-FAOD) Extension Study for Subjects Previously Enrolled in Triheptanoin Studies
ClinicalTrials.gov study NCT02214160. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Association Between Increased Oxidative Stress, Anti-Inflammatory Fatty Acid Formation, and Airway Infection in People With Asthma and Chronic Obstructive Pulmonary Disease
ClinicalTrials.gov study NCT00595114. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Fatty Acid Oxidation Disorders & Body Weight Regulation Grant
ClinicalTrials.gov study NCT00654004. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Measuring Fatty Acid Oxidation in Gliomas Using 18F-FPIA PET/MRI
ClinicalTrials.gov study NCT04097535. IPD Sharing: NO. Countries: 1. Publications: 1.
Study of Triheptanoin for Treatment of Long-Chain Fatty Acid Oxidation Disorder
ClinicalTrials.gov study NCT01379625. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Measuring Fatty Acid Oxidation in Cerebral Metastases Using [18F]FPIA
ClinicalTrials.gov study NCT04807582. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study of UX007 (Triheptanoin) in Participants With Long-Chain Fatty Acid Oxidation Disorders (LC-FAOD)
ClinicalTrials.gov study NCT01886378. IPD Sharing: Not stated. Countries: 2. Publications: 4.
Effect of Omega 3 Fatty Acids on Oxidative Stress in HIV Seropositive Patients
ClinicalTrials.gov study NCT02041520. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Fatty acid oxidation: A neglected factor in understanding the adjustment of mitochondrial function to cold temperatures
<p>For ectothermic species, adaptation to thermal changes is of critical importance. Mitochondrial oxidative phosphorylation (OXPHOS), which leverages multiple electron pathways to produce energy needed for survival, is among the crucial metabolic processes impacted by temperature. Our aim in this study was to identify how changes in temperature affect the less-studied electron transferring flavoprotein pathway, fed by fatty acid substrates. We used the planarian Dugesia tigrina, acclimated for 4 weeks at 10°C (cold acclimated) or 20°C (normothermic). Respirometry experiments were conducted at an assay temperature of either 10 or 20°C to study specific states of the OXPHOS process using the fatty acid substrates palmitoylcarnitine (long chain), octanoylcarnitine (medium chain) or acetylcarnitine (short chain). Following cold acclimation, octanoylcarnitine exhibited increases in both the OXPHOS and electron transfer (ET, non-coupled) states, indicating that the pathway involved in medium-chain length fatty acids adjusts to cold temperatures. Acetylcarnitine only showed an increase in the OXPHOS state as a result of cold acclimation, but not in the ET state, indicative of a change in phosphorylation system capacity rather than fatty acid β-oxidation. Palmitoylcarnitine oxidation was unaffected. Our results show that cold acclimation in D. tigrina caused a specific adjustment in the capacity to metabolize medium-chain fatty acids rather than an adjustment in the activity of the enzymes carnitineacylcarnitine translocase, carnitine acyltransferase and carnitine palmitoyltransferase-2. Here, we provide novel evidence of the alterations in fatty acid β-oxidation during cold acclimation in D. tigrina.</p>
Common Blackbird weights, activity, fatty acid oxidation rates, and metabolic rates
<p>Seasonal migration is a physiologically-demanding endeavor that animals prepare for by finding and storing energy. Species and populations vary in their tendencies to migrate, and the energetic demands of migration likely determine the degree and type of preparation that different animals undergo. </p> <p>Birds fuel their migratory flight using stored fat. Previous work has suggested that in addition to being energetically-dense, certain lipids like polyunsaturated fatty acids (PUFAs) may be particularly efficient fuels that are preferentially mobilized for flight or serve may additional functions, such as modulating membrane fluidity or stimulating gene expression as ligands, during long-distance migratory flight. </p> <p>Using a series of behavioral and metabolic experiments in a common garden setting of Common Blackbirds (<em>Turdus merula</em>) populations that range from being fully-migratory to partially-migratory to sedentary, we asked how migratory restlessness (<em>Zugunruhe</em>), weight gain, and oxidation of stearic acid (18:0), oleic acid (18:1n-9), linoleic acid (18:2n-6), and alpha linolenic acid (18:3n-3; ALA) varied with migratory mode and season.</p> <p>We found no population-level differences in the timing of <em>Zugunruhe</em>. However, before migration, a greater proportion of individuals from fully-migratory populations exhibited weight gain and migratory restlessness, as well as increased oxidation of PUFAs. After <em>Zugunruhe</em>, only individuals from migratory populations showed reduced PUFA oxidation. All populations showed increased oxidation of saturated fat after <em>Zugunruhe</em>.</p> <p>Our results demonstrate that certain migratory traits, like the timing of <em>Zugunruhe</em> based on local environmental conditions, are more similar across populations, while others, like lipid oxidation, can vary at the population-level.</p>
Oxidative Stress and Fatty Acids in Hepatitis C
ClinicalTrials.gov study NCT00444002. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effect of Triheptanoin on Fatty Acid Oxidation and Exercise Tolerance in Patients With Glycogenoses
ClinicalTrials.gov study NCT03642860. IPD Sharing: UNDECIDED. Countries: 1. Publications: 34.
Fatty Acids Lipidome and Oxidative Stress in Liver Transplantation
ClinicalTrials.gov study NCT01389115. IPD Sharing: Not stated. Countries: 1. Publications: 8.
The Combined Effect of Omega-3 Fatty Acid and Vitamin D3 on Lipid Profile Levels and Oxidized Low Density Lipoprotein
ClinicalTrials.gov study NCT04005573. IPD Sharing: YES. Countries: 1. Publications: 1.
Common Blackbird weights, activity, fatty acid oxidation rates, and metabolic rates
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Fatty acid oxidation: A neglected factor in understanding the adjustment of mitochondrial function to cold temperatures
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Fig. 2. Key 1H–1H in Fatty acid acylated flavonol glycosides from the seeds of Nephelium lappaceum and their nitric oxide suppression activity
Fig. 2. Key 1H–1H COSY and HMBC correlations of compounds 1–5.
Fig. 1 in Fatty acid acylated flavonol glycosides from the seeds of Nephelium lappaceum and their nitric oxide suppression activity
Fig. 1. Structures of all isolated compounds from the seeds of N. lappaceum.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.