Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
8
datasets available to search
ShareScore release 0.9.0
Dataset results
8 results for “flupyradifurone”
R code for: Following regulation, imidacloprid persists and flupyradifurone increases in non-target wildlife
<p>After regulation of pesticides, determination of their persistence in the environment is an important indicator of effectiveness of these measures. We quantified concentrations of two types of systemic insecticides: neonicotinoids (imidacloprid, acetamiprid, clothianidin, thiacloprid, and thiamethoxam) and butenolides (flupyradifurone), in off-crop non-target media of hummingbird cloacal fluid, honey bee (<em>Apis mellifera</em>) nectar and honey, and wildflowers before and after regulation of imidacloprid on highbush blueberries in Canada in April 2021. We found that mean total pesticide load increased in hummingbird cloacal fluid, nectar, and flower samples following imidacloprid regulation. On average, we did not find evidence of a decrease in imidacloprid concentrations after regulation. However, there were some decreases, some increases and other cases with no changes in imidacloprid levels depending on the specific media, time point of sampling and site type. At the same time, we found an overall increase in flupyradifurone, acetamiprid, thiamethoxam and thiacloprid, but no change in clothianidin concentrations. In particular, flupyradifurone concentrations observed in biota sampled near to agricultural areas increased by 2-fold in honey bee nectar, 7-fold in hummingbird cloacal fluid, and 8-fold in flowers after the 2021 imidacloprid regulation. The highest residue detected in this study was flupyradifurone at 665 ng/mL (PPB) in honey bee nectar. Mean total pesticide loads were highest in honey samples (84 ± 10 PPB) followed by nectar (56 ± 7 PPB), then hummingbird cloacal fluid (1.8 ± 0.5 PPB), and least, flowers (0.51 ± 0.06 PPB). Our results highlight that limited regulation of imidacloprid does not immediately reduce residue concentrations while other systemic insecticides, possibly replacement compounds, concurrently increase in wildlife.</p>
R code for: Following regulation, imidacloprid persists and flupyradifurone increases in non-target wildlife
Open the record for dataset details and reuse information.
Data from: Lethal and sublethal synergistic effects of a new systemic pesticide, flupyradifurone (Sivanto®) on honey bees
The honey bee (Apis mellifera L.) is an important pollinator and a model for pesticide effects on insect pollinators. The effects of agricultural pesticides on honey bee health have therefore raised concern. Bees can be exposed to multiple pesticides that may interact synergistically, amplifying their side-effects. Attention has focused on neonicotinoid pesticides, but flupyradifurone (FPF) is a novel butenolide insecticide that is also systemic and a nicotinic acetylcholine receptor (nAChR) agonist. We therefore tested the lethal and sublethal toxic effects of FPF over different seasons and worker types, and the interaction of FPF with a common SBI fungicide, propiconazole. We provide the first demonstration of adverse synergistic effects on bee survival and behaviour (poor coordination, hyperactivity, apathy) at field-realistic doses. Pesticide effects were significantly influenced by worker type and season. Foragers were consistently more susceptible to these pesticides (4-fold greater effect) than in-hive bees, and both worker types were more strongly affected by FPF in summer as compared to spring. Because risk assessment requires relatively limited tests that only marginally address bee behaviour and do not consider the influence of bee age and season, our results raise concerns about the safety of approved pesticides, including FPF. We suggest that pesticide risk assessment also test for common chemical mixture synergies on behaviour and survival.
Data from: Field-realistic exposure to the novel insecticide flupyradifurone reduces reproductive output in a bumblebee (Bombus impatiens)
<p>Novel insecticides are continuously being developed for application in response to increased legal restriction of previously developed insecticides and resistance in target insects. These novel insecticides, such as flupyradifurone (FPF), remain relatively untested on non-target organisms, including bumblebees. Further, existing tests on honeybees tend to focus on adult mortality, and thus sub-lethal effects, such as impacts on reproductive output, are neglected, despite their importance for population-level impacts. To address if the novel insecticide FPF has sub-lethal effects on bumblebee reproduction and behavior, we established microcolonies and chronically exposed them to field-realistic concentrations over a 14-day period. We found that exposure to FPF reduced the bumblebees' reproductive output in terms of the number of larvae produced and the mean mass of each larval instar. FPF-treated bees also stored less sucrose and constructed fewer honeypots. However, adult bumblebee mortality was similar between control and FPF-exposed microcolonies. Our results show that field-realistic FPF exposure leads to increased larval mortality and/or delayed larval development, as well as reduced nectar storage, without affecting adult mortality. Policy implications: Insecticides that impair bumblebee reproduction can have long-term population-level consequences, even if adult bees do not experience increased mortality. Despite this fact, sub-lethal effects, such as impacts on reproduction, are not mandatorily assessed within the regulatory process. Our findings highlight the importance of determining sub-lethal effects of pesticides across developmental stages, as well as using pollinator species other than honeybees within the regulatory process.</p>
Data from: Lethal and sublethal synergistic effects of a new systemic pesticide, flupyradifurone (Sivanto®) on honey bees
Open the record for dataset details and reuse information.
Data from: Field-realistic exposure to the novel insecticide flupyradifurone reduces reproductive output in a bumblebee (Bombus impatiens)
Open the record for dataset details and reuse information.
Effects of Nosema ceranae (DISSOCIODIHAPLOPHASIDA: Nosematidae) and flupyradifurone on olfactory learning in honey bees, Apis mellifera (HYMENOPTERA: Apidae)
<p>The health of insect pollinators, particularly the honey bee, <em>Apis mellifera </em>(Linnaeus, 1758), is a major concern for agriculture and ecosystem health. In response to mounting evidence supporting the detrimental effects of neonicotinoid pesticides on pollinators, a novel “bee safe” butenolide compound, flupyradifurone (FPF) has been registered for agricultural use. Although FPF is not a neonicotinoid, like neonicotinoids, it is an excitotoxic nicotinic acetylcholine receptor agonist. In addition, <em>A. mellifera</em> faces threats from pathogens, such as the microsporidian endoparasite,<em> Nosema ceranae</em> (Fries et al., 1996). We therefore sought (1) to increase our understanding of the potential effects of FPF on honey bees by focusing on a crucial behavior, the ability to learn and remember an odor associated with a food reward, and (2) to test for a potential synergistic effect on such learning by exposure to FPF and infection with <em>N. ceranae. </em>We found little evidence that FPF significantly alters learning and memory at short-term field-realistic doses. However, at high doses and at chronic, field-realistic exposure, FPF did reduce learning and memory in an olfactory conditioning task. Infection with <em>N. ceranae</em> also reduced learning, but there was no synergy (no significant interaction) between<em> N. ceranae</em> and exposure to FPF. These results suggest the importance of continued studies on the chronic effects of FPF.</p>
Sub-lethal but potentially devastating – The novel insecticide flupyradifurone impairs collective brood care in bumblebees
<p>The worldwide decline in pollinating insects is alarming. One of the main anthropogenic drivers is the massive use of pesticides in agriculture. Risk assessment procedures test pesticides for mortality rates of well-fed, parasite-free individuals of a few non-target species. Sublethal and synergistic effects of co-occurring stressors are usually not addressed. Here, we present a simple, high-throughput bio-essay to assess such effects. Using brood thermoregulation in bumblebee microcolonies as readout, we investigate how this collective ability is affected by long-term feeding exposure to the herbicide glyphosate (5 mg/l), the insecticide flupyradifurone (0.4 mg/l) and the combination of both, when co-occurring with the natural stressor resource limitation compared. Documenting brood temperature and development in 53 microcolonies, we find no significant effect of glyphosate, while flupyradifurone significantly impaired the collective ability to maintain the necessary brood temperatures, resulting in prolonged developmental times and a decrease in colony growth by over fifty percent. This reduction in colony growth has the potential to significantly curtail reproductive chances of colonies in the field. Our findings highlight the potentially alarming consequences of flupyradifurone use in agriculture even at sub-lethal doses and underline the urgent need for improved risk assessment procedures.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.