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5 results for “force depression”
Data from: Effects of a titin mutation on force enhancement and force depression in mouse soleus muscles
The force produced by muscles varies with muscle length. Compared to isometric contractions at the same final length, force increases after lengthening, known as force enhancement, and decreases after shortening, known as force depression. The mechanisms of force enhancement remain unexplained by the sliding-filament and cross-bridge theories of muscle contraction. Although cross-bridge mechanisms have been proposed to account for force depression, so too have other mechanisms. In addition to cross bridges, titin has been suggested to contribute to both force enhancement and depression. Although titin is too compliant in passive muscles to contribute to active stiffness, recent evidence suggests that calcium activation increases titin stiffness. To test the hypothesis that titin plays a role in force enhancement and depression, we investigated muscle force in active and passive wild type and mdm soleus muscles after isovelocity stretching and shortening at three activation levels. Muscles from mdm mice (muscular dystrophy with myositis) have a predicted 83 amino acid deletion in the N2A region of titin and show no increase in stiffness when activated. We found that: 1) force enhancement and depression were reduced in mdm soleus compared to wild type muscles; 2) force enhancement increased with the amplitude of stretch across all activation levels in wild type and mdm muscles, while force depression increased with amplitude in wild type but not in mdm muscles; and 3) maximal shortening velocity of wild type and mdm muscles was similar, although active stress was reduced in mdm compared to wild type muscles. The results of this study suggest a role for titin in force enhancement and depression, which contribute importantly to regulation of muscle force during natural movements.
Residual force depression data
<p>Raw data used to create the results text and figures presented in the manuscript entitled "Residual force depression is not related to positive muscle fascicle work during submaximal voluntary dorsiflexion contractions in humans".</p>
Data from: Effects of a titin mutation on force enhancement and force depression in mouse soleus muscles
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Outreach and Treatment for Depression in the Labor Force
ClinicalTrials.gov study NCT00057590. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Gene expression alteration in the hippocampus of depression mouse model with forced swim stress
GEO Series GSE223430. Mus musculus; Mus. 6 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.