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89 results for “foregut”
Molecular deciphering of primary liver neuroendocrine neoplasms confirms its distinct existence with foregut-like profile
<p>Isolated hepatic localizations of neuroendocrine tumors (NETs) are generally considered as metastatic NETs of unknown primary but could correspond to primary hepatic NETs (PHNETs), a poorly explored entity. We aimed to describe the clinicopathological and molecular features of PHNETs and compare them with other primary NETs. We assembled a retrospective cohort of patients managed for hepatic localization of NET without extra-hepatic primary tumor after exhaustive clinical, imaging and immunohistochemical characterization. We performed whole-exome sequencing with mutational and copy number analysis. Transcriptomic profiles were compared to pancreatic (n=31), small-bowel (n=22) and lung (n=15) NETs using principal component analysis, unsupervised clustering and gene-set enrichment analysis.Among 27 screened patients, 16 had PHNET (solitary tumor in 63%, median size 11 cm, G2 NETs in 81%) following clinical and pathological review. DNA analyses showed “foregut-like” genomic profiles with frequent alterations in pathways of Fanconi DNA repair (75%), histone modifiers (58%), adherens junctions (58%) and cell cycle control (50%). The most frequently involved genes were <em>KMT2A</em> (58%), <em>ATM</em> (42%), <em>CDH1</em>, <em>CDKN2C</em>, <em>FANCF</em> and <em>MEN1</em> (33% each). Transcriptomic analyses showed that PHNETs clustered closer to foregut (pancreatic, lung) NETs than to midgut (small-bowel) NETs, while remaining a distinct entity with specific profile. Assessment of potentially predictive biomarkers suggested efficacy of treatments usually active in foregut NETs. In conclusion, PHNETs display a foregut-like molecular profile distinct from other types of NETs, with recurrent molecular alterations. Upon exhaustive work-up to exclude unrecognized primary tumor, PHNETs should not be considered metastatic NETs from an unknown primary.</p>
FIGURE 31 in Recent developments on the morphology of the brachyuran foregut ossicles and gastric teeth
FIGURE 31. Foregut ossicles and gastric teeth of Lithodes maja (Linnaeus, 1758), A. dorsal view, B. lateral view, C. lateral tooth, D. accessory teeth, E. dorso-median tooth, F. cardio-pyloric valve; scales: A. & B. 1mm, C. 300µm, D. 100µm, E. 300µm, F. 200µm.
FIGURE 30 in Recent developments on the morphology of the brachyuran foregut ossicles and gastric teeth
FIGURE 30. Foregut ossicles and gastric teeth of Orconectes limosus (Rafinesque, 1817), A. dorsal view, B. lateral view, C. lateral tooth, D. accessory teeth, E. dorso-median tooth, F. cardio-pyloric valve; scales: A. & B. 1mm, C. 200µm, D. 100µm, E. & F. 200µm.
FIGURE 29 in Recent developments on the morphology of the brachyuran foregut ossicles and gastric teeth
FIGURE 29. Foregut ossicles and gastric teeth of Pseudosesarma moeschi (De Man, 1888), A. dorsal view, B. lateral view, C. lateral tooth, D. accessory teeth, E. dorso-median tooth, F. cardio-pyloric valve; scales: A. & B. 1mm, C. – F. 200µm.
FIGURE 28 in Recent developments on the morphology of the brachyuran foregut ossicles and gastric teeth
FIGURE 28. Foregut ossicles and gastric teeth of Cardisoma armatum Herklots, 1851, A. dorsal view, B. lateral view, C. lateral tooth, D. accessory teeth, E. dorso-median tooth, F. cardio-pyloric valve, scales: A. – C. & E. 1mm, D. 200µm, F. 200µm.
FIGURE 27 in Recent developments on the morphology of the brachyuran foregut ossicles and gastric teeth
FIGURE 27. Foregut ossicles and gastric teeth of Mictyris longicarpus Latreille, 1806, A. dorsal view, B. lateral view, C. lateral tooth, D. accessory teeth, E. dorso-median tooth, F. cardio-pyloric valve; scales: A. & B. 1mm, C. & D. 100µm, E. 200µm, F. 300µm.
FIGURE 23 in Recent developments on the morphology of the brachyuran foregut ossicles and gastric teeth
FIGURE 23. Foregut ossicles and gastric teeth of Retropluma quadrata Saint Laurent, 1989, A. dorsal view, B. lateral view, C. lateral tooth, D. accessory teeth, E. dorso-median tooth, F. cardio-pyloric valve; scales: A. & B. 1mm, C. – F. 100µm.
FIGURE 21 in Recent developments on the morphology of the brachyuran foregut ossicles and gastric teeth
FIGURE 21. Foregut ossicles and gastric teeth of Potamonautes lirrangensis (Rathbun, 1904), A. dorsal view, B. lateral view, C. lateral tooth, D. accessory teeth; scales: A. & B. 1mm, C. 300µm, D. 400µm.
FIGURE 26 in Recent developments on the morphology of the brachyuran foregut ossicles and gastric teeth
FIGURE 26. Foregut ossicles of Uca (Minuca) rapax (Smith, 1870), A. dorsal view, B. lateral view; gastric teeth of Uca (Gelasimus) tetragonon (Herbst, 1790), C. lateral tooth, D. accessory teeth, E. dorso-median tooth, F. cardio-pyloric valve; scales: A. & B. 1mm, C. 200µm, D. 100µm, E. & F. 200µm.
FIGURE 20 in Recent developments on the morphology of the brachyuran foregut ossicles and gastric teeth
FIGURE 20. Foregut ossicles and gastric teeth of Rhithropanopeus harrisii (Gould, 1841), A. dorsal view, B. lateral view, C. lateral tooth, D. accessory teeth, E. dorso-median tooth, F. cardio-pyloric valve; scales: A. & B. 1mm, C. 200µm, D. – F. 100µm.
FIGURE 19 in Recent developments on the morphology of the brachyuran foregut ossicles and gastric teeth
FIGURE 19. Foregut ossicles and gastric teeth of Leptodius sanguineus (H. Milne Edwards, 1834), A. dorsal view, B. lateral view, C. lateral tooth, D. accessory teeth, E. dorso-median tooth, F. cardio-pyloric valve; scales: A. & B. 1mm, C. 200µm, D. 100µm, E. & F. 200µm.
FIGURE 17 in Recent developments on the morphology of the brachyuran foregut ossicles and gastric teeth
FIGURE 17. Foregut ossicles and gastric teeth of Hexaplax megalops Doflein, 1904, A. dorsal view, B. lateral view; C. lateral tooth, D. accessory teeth, E. dorso-median tooth, F. cardio-pyloric valve; scales:scales: A. & B. 1mm, C. 100µm, D. 100µm, E. & F. 300µm.
FIGURE 16 in Recent developments on the morphology of the brachyuran foregut ossicles and gastric teeth
FIGURE 16. Foregut ossicles of Segonzacia mesatlantica (Williams, 1988), A. dorsal view, B. lateral view; gastric teeth of Austinograea alayseae Guinot, 1990, C. lateral tooth, D. accessory teeth, E. dorso-median tooth, F. cardio-pyloric valve; scales: A. & B. 1mm, C. 300µm, D. 100 µm, E. & F. 300µm.
FIGURE 18 in Recent developments on the morphology of the brachyuran foregut ossicles and gastric teeth
FIGURE 18. Foregut ossicles of Trapezia lutea Castro, 1997, A. dorsal view, B. lateral view; gastric teeth of Trapezia cymodoce (Herbst, 1801), C. lateral tooth, D. accessory teeth, E. dorso-median tooth, F. cardio-pyloric valve; scales: A. & B. 0,5mm, C. – F. 100µm.
FIGURE 15 in Recent developments on the morphology of the brachyuran foregut ossicles and gastric teeth
FIGURE 15. Foregut ossicles and gastric teeth of Carpilius convexus (Forskål, 1775), A. dorsal view, B. lateral view, C. lateral tooth, D. accessory teeth, E. dorso-median tooth, F. cardio-pyloric valve; scales: A. & B. 1mm, C. 200µm, D. 100µm, E. & F. 200µm.
FIGURE 13 in Recent developments on the morphology of the brachyuran foregut ossicles and gastric teeth
FIGURE 13. Foregut ossicles of Liocarcinus depurator (Linnaeus, 1758), A. dorsal view, B. lateral view; gastric teeth of Callinectes sapidus Rathbun, 1896, C. lateral tooth, D. accessory teeth, E. dorso-median tooth, F. cardio-pyloric valve; scales: A. & B. 2mm, C. 1mm, D. 200µm, E. 1mm, F. 300µm.
FIGURE 12 in Recent developments on the morphology of the brachyuran foregut ossicles and gastric teeth
FIGURE 12. Foregut ossicles and gastric teeth of Philyra variegata (Rüppell, 1830), A. dorsal view, B. lateral view, C. lateral tooth, D. accessory teeth, E. dorso-median tooth, F. cardio-pyloric valve; scales: A. & B. 1mm, C. – F. 100µm.
FIGURE 14 in Recent developments on the morphology of the brachyuran foregut ossicles and gastric teeth
FIGURE 14. Foregut ossicles and gastric teeth of Cancer pagurus Linnaeus, 1758, A. dorsal view, B. lateral view, C. lateral tooth, D. accessory teeth, E. dorso-median tooth; scales: A. & B. 1mm, C. 300µm, D. 100µm, E. 300µm, F. 1mm.
FIGURE 22 in Recent developments on the morphology of the brachyuran foregut ossicles and gastric teeth
FIGURE 22. Foregut ossicles and gastric teeth of Nepinnotheres villosulus (Guérin, 1831), A. dorsal view, B. lateral view, C. lateral tooth, D. accessory teeth, E. dorso-median tooth; scales: A. & B. 1mm, C. – E. 100µm.
FIGURE 10 in Recent developments on the morphology of the brachyuran foregut ossicles and gastric teeth
FIGURE 10. Foregut ossicles and gastric teeth of Cymonomus granulatus (Norman, in Wyville Thomson, 1873), A. dorsal view, B. lateral view, C. lateral tooth, D. accessory teeth, E. dorso-median tooth, F. cardio-pyloric valve; scales: A. & B. 1mm, C. – F. 100µm.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.