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9 results for “fructosamine”
Data from: Metabolic changes associated with two endocrine abnormalities in dogs: elevated fructosamine and low thyroxine
<p>Metabolomics studies in canine endocrine abnormalities are sparse and basic information on these abnormalities must be generated. This dataset includes the 1H NMR metabolic profiling results of 151 dog serum samples. The samples have been collected in an ethical way, being leftovers of clinical diagnostic samples. The sample set includes 25 control samples based on unremarkable routine clinical chemistry and hematology, 79 samples exhibiting high fructosamine which reflects poor glycemic control, and 47 samples with low thyroxine, a metabolically important thyroid hormone.</p> <p>The metabolite data and metadata were utilized in the study: Ottka et al. Metabolic changes associated with two endocrine abnormalities in dogs: elevated fructosamine and low thyroxine.</p> <p>The control group results were utilized also in: Ottka et al. Serum NMR metabolomics uncovers multiple metabolic changes in phenobarbital-treated dogs.</p>
Data from: Metabolic changes associated with two endocrine abnormalities in dogs: elevated fructosamine and low thyroxine
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Data from: The shepherds' tale: a genome-wide study across 9 dog breeds implicates two loci in the regulation of fructosamine serum concentration in Belgian shepherds
Diabetes mellitus is a serious health problem in both dogs and humans. Certain dog breeds show high prevalence of the disease, whereas other breeds are at low risk. Fructosamine and glycated hemoglobin (HbA1c) are two major biomarkers of glycaemia where serum concentrations reflect glucose turnover over the past few weeks to months. In this study, we searched for genetic factors influencing variation in serum fructosamine concentration in healthy dogs using data from nine dog breeds. Considering all breeds together, we did not find any genome-wide significant associations to fructosamine serum concentration. However, by performing breed-specific analyses we revealed an association on CFA 3 (pcorrected ≈ 1.68 × 10−6) in Belgian shepherd dogs. The associated region and its close neighborhood harbours interesting candidate genes such as LETM1 and GAPDH that are important in glucose metabolism and have previously been implicated in the aetiology of diabetes mellitus. To further explore the genetics of this breed specificity, we screened the genome for reduced heterozygosity stretches private to the Belgian shepherd breed. This revealed a region with reduced heterozygosity that shows a statistically significant interaction (p = 0.025) with the association region on CFA3. This region also harbours some interesting candidate genes and regulatory regions but the exact mechanisms underlying the interaction are still unknown. Nevertheless, this finding provides a plausible explanation for breed-specific genetic effects for complex traits in dogs. Shepherd breeds are at low risk of developing diabetes mellitus. The findings in Belgian shepherds could be connected to a protective mechanism against the disease. Further insight into the regulation of glucose metabolism could improve diagnostic and therapeutic methods for diabetes mellitus.
Glycemic Control Based on Serum Fructosamine Concentration vs. hemoglobinA1c (HbA1c) in Diabetic Patients
ClinicalTrials.gov study NCT04079660. IPD Sharing: NO. Countries: 1. Publications: 12.
Fructosamines and Gestational Diabetes (FRUCTO)
ClinicalTrials.gov study NCT02159378. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Data from: The shepherds' tale: a genome-wide study across 9 dog breeds implicates two loci in the regulation of fructosamine serum concentration in Belgian shepherds
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Illuminating the functions of understudied Fructosamine-3-kinase (FN3K) using a multi-omics approach reveals new links to nicotinamide adenine dinucleotides (NAD)
GEO Series GSE242555. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
The oncogenic action of NRF2 depends on de-glycation by Fructosamine-3-kinase (FN3K)
GEO Series GSE133160. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Fructosamine as a Predictor of Surgical Outcomes in Total Joint Arthroplasty A Prospective Multi-center Study
ClinicalTrials.gov study NCT03503019. IPD Sharing: Not stated. Countries: 0. Publications: 0.
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