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Dataset results
34 results for “functional innovation”
Data from: A classic key innovation constrains oral jaw functional diversification in fishes
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Data from: Coincident transitions across elevation and origins of functional innovations drove the phenotypic and ecological diversity of lungless salamanders
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Prototype of Innovative Food Product to Improve Respiratory and Peripheral Muscle Function in Humans
ClinicalTrials.gov study NCT06248437. IPD Sharing: NO. Countries: 1. Publications: 4.
Pre-operative Mapping of the Anterior Temporal Lobe Using Functional MRI Innovative Techniques in in Drug-resistant Epileptic Patients
ClinicalTrials.gov study NCT05339438. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Development Of An Innovative Panel of Methods To Measure Intestinal Macronutrient Digestion, Absorption, and Function
ClinicalTrials.gov study NCT01494909. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Synergistic Innovative Functional Food Concepts to Neutralize Inflammation for Cardiometabolic Risk Prevention
ClinicalTrials.gov study NCT04190706. IPD Sharing: NO. Countries: 1. Publications: 2.
Exploring Innovative Strategies to Enhance Eye-Hand Coordination and Cognitive Functions Through Drone Catching Exercise.
ClinicalTrials.gov study NCT07394231. IPD Sharing: UNDECIDED. Countries: 1. Publications: 10.
Functional Innovation and Application Research of Domestic Advanced Low-Dose DSA/CT-DSA
ClinicalTrials.gov study NCT06762613. IPD Sharing: NO. Countries: 1. Publications: 6.
Data from: Closing the achievement gap through modification of neurocognitive and neuroendocrine function: results from a cluster randomized controlled trial of an innovative approach to the education of children in kindergarten
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Data from: Functional innovation promotes diversification of form in the evolution of an ultrafast trap-jaw mechanism
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Data from: Decoupled diversification dynamics of feeding morphology following a major functional innovation in marine butterflyfishes
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A Peacock Bass (Cichla) functional novelty relaxes a constraint imposed by the classic cichlid pharyngeal jaw innovation
Innovations may provide access to new resources but often result in significant trade-offs. Pharyngognathy is a classic pharyngeal jaw innovation in which the left and right lower pharyngeal jaw (LPJ) bones are united into a single structure, producing a strong bite but reduced gape. Throughout cichlids, pharyngeal suturing occurs along the entire medial border between LPJ bones, except in Peacock bass (Cichla), where these bones are connected by ligaments only in their anterior region. We show that this limited attachment permits the jaw bones to spread apart and we link this feature to an increase in pharyngeal gape that is comparable to non-pharyngognathous species. The capacity of the LPJ bones to spread apart is strongest in juveniles and is mostly lost during development. Juvenile Cichla exhibit size-specific pharyngeal gape similar to non-pharyngognathous percomorphs, but adults exhibit pharyngeal gape on par with other predatory cichlids. Relaxation of pharyngeal suturing offsets a major deleterious consequence of pharyngognathy by reducing gape limitation and we propose this may accelerate the ontogenetic transition to piscivory. Partial reversal of the classic cichlid pharyngeal jaw innovation highlights the functional trade-offs that often accompany innovations and may be a major cause of variation in their macroevolutionary consequences.
Data from: Adaptive radiation in labrid fishes: a central role for functional innovations during 65 My of relentless diversification
Early burst patterns of diversification have become closely linked with concepts of adaptive radiation, reflecting interest in the role of ecological opportunity in modulating diversification. But, this model has not been widely explored on coral reefs, where biodiversity is exceptional, but many lineages have high dispersal capabilities and a pan-tropical distribution. We analyze adaptive radiation in labrid fishes, arguably the most ecologically dominant and diverse radiation of fishes on coral reefs. We test for time-dependent speciation, trophic diversification, and origination of 15 functional innovations, and early bursts in a series of functional morphological traits associated with feeding and locomotion. We find no evidence of time-dependent or early burst evolution. Instead, the pace of speciation, ecological diversification, and trait evolution has been relatively constant. The origination of functional innovations has slowed over time, although few arose early. The labrid radiation seems to have occurred in response to extensive and still increasing ecological opportunity, but within a rich community of antagonists that may have prevented abrupt diversification. Labrid diversification is closely tied to a series of substantial functional innovations that individually broadened ecological diversity, ultimately allowing them to invade virtually every trophic niche held by fishes on coral reefs.
Data from: The evolution of pharyngognathy: a phylogenetic and functional appraisal of the pharyngeal jaw key innovation in labroid fishes and beyond
The perciform group Labroidei includes approximately 2,500 species and comprises some of the most diverse and successful lineages of teleost fishes. Composed of four major clades, Cichlidae, Labridae (wrasses, parrotfishes and weed whitings), Pomacentridae (damselfishes), and Embiotocidae (surfperches), labroids have been an icon for studies of biodiversity, adaptive radiation, and sexual selection. The success and diversification of labroids have been largely attributed to the presence of a major innovation in the pharyngeal jaw apparatus, pharyngognathy, which is hypothesized to increase feeding capacity and versatility. We present results of large-scale phylogenetic analyses and a survey of pharyngeal jaw functional morphology, that allow us to examine the evolution of pharyngognathy in a historical context. Phylogenetic analyses were based on a sample of 188 acanthomorph species, primarily percomorphs, and DNA sequence data collected from ten nuclear loci that have been previously used to resolve higher-level ray-finned fish relationships. Phylogenies inferred from this dataset using maximum likelihood and Bayesian analyses indicate polyphyly of the traditional Labroidei and clearly separate Labridae from the remainder of the traditional labroid lineages (Cichlidae, Embiotocidae, and Pomacentridae). These three "chromide" families all grouped together within a newly discovered clade of 40 families and more than 5,300+ species (>30% of percomorphs and >17% of all ray-finned fishes), which we name Ovalentaria for its characteristic demersal, adhesive eggs with chorionic filaments. This fantastically diverse clade includes some of the most species-rich lineages of marine and freshwater fishes, including all representatives of the Cichlidae, Embiotocidae, Pomacentridae, Ambassidae, Gobiesocidae, Grammatidae, Mugilidae, Opistognathidae, Pholidichthyidae, Plesiopidae (including Notograptus), Polycentridae, Pseudochromidae, Atherinomorpha, and Blennioidei. Beyond the discovery of Ovalentaria, this study provides a surprising, but well-supported, hypothesis for a convict-blenny (Pholidichthys) sister group to the charismatic cichlids and new insights into the evolution of pharyngognathy. Bayesian stochastic mapping ancestral state reconstructions indicate pharyngognathy has evolved at least six times in percomorphs, including four separate origins in members of the former Labroidei, one origin in the Centrogenyidae, and one origin within Beloniformes. Our analyses indicate that all pharyngognathous fishes have a mechanically efficient biting mechanism enabled by the muscular sling and a single lower jaw element. However, a major distinction exists between Labridae, which lacks the widespread, generalized percomorph pharyngeal biting mechanism, and all other pharyngognathous clades, which possess this generalized biting mechanism in addition to pharyngognathy. This suggests that labrids have a functionally more restricted pharyngeal system than all other pharyngognathous clades.
FUNCTIONS OF FACTS DEVICES WITH INNOVATION TECHNOLOGY IN THE ELECTRICAL ENERGY SYSTEM
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Identifying GPCRs involved in adipose tissue function using the innovative RNA-seq database FATTLAS
<p>G protein-coupled receptors (GPCRs) modulate the function of adipose tissue (AT) in general and of adipocytes, specifically. Although it is well-established that GPCRs are widely expressed in AT, their repertoire as well as their regulation and function in (patho)physiological conditions (e.g., obesity) is not fully resolved. Here, we established FATTLAS, an interactive public database, for improved access and analysis of RNA-seq data of mouse and human AT. After extracting the GPCRome of non-obese and obese individuals, highly expressed and regulated GPCRs were identified. Exemplarily, we describe four receptors (MRGPRF, GPR146, FZD5, PTGER2) and analyzed their functions in a (pre)adipocyte cell model. Besides all receptors being involved in adipogenesis, MRGPRF is essential for adipocyte viability and regulates cAMP levels, while GPR146 modulates adipocyte lipolysis via constitutive activation of Gi proteins. Taken together, by implementing and using FATTLAS we describe four hitherto unrecognized GPCRs associated with AT function and adipogenesis.</p>
Spinal Cord Innovation in Pediatrics (SCiP) to Treat SensoriMotor Function in Children Cerebral Palsy: Protocol for a Randomized Controlled Trial
ClinicalTrials.gov study NCT05720208. IPD Sharing: NO. Countries: 0. Publications: 1.
Data from: The evolution of pharyngognathy: a phylogenetic and functional appraisal of the pharyngeal jaw key innovation in labroid fishes and beyond
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Data from: Adaptive radiation in labrid fishes: a central role for functional innovations during 65 My of relentless diversification
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Data from: Functional innovation through vestigialisation in a modular marine invertebrate
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.