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12 results for “functional metagenome”
Metagenomes: gene function and family annotations
<p>Functional annotations of genes for all contigs in 1,782 metagenomes.</p> <p>Genes were annotated to three sources: (1) COGs, (2) Pfams, and (3) <em>de novo</em> families from reference sequences. These gene annotations are used to train and run PlasX.</p>
MAG Collection - Rühlemann et al.: Comparative metagenomics reveals host-specific functional adaptation of intestinal microbiota across hominids
<p>This tar-Archives hold the complete collection of n=7,506 metagenome-assembled genomes presented in the preprint "Comparative metagenomics reveals host-specific functional adaptation of intestinal microbiota across hominids" by Rühlemann <em>et al., <a href="https://www.biorxiv.org/content/10.1101/2023.03.01.530589v1">bioRxiv</a>, </em>2023.</p> <p>Article Summary</p> <p>Characterizing trajectories of the composition and function of hominid gut microbiota across diverse environments and host species can help reveal specific properties of the human microbiota, with possible implications for host evolution and health. Using shotgun metagenomic sequencing, we investigated taxonomic and functional diversity in the gut microbiota of wild-living great apes, including two gorilla subspecies (<em>Gorilla gorilla gorilla, Gorilla beringei beringei</em>), three chimpanzee subspecies (<em>Pan troglodytes verus, P.t. troglodytes, P.t. schweinfurthii</em>), and bonobos (<em>Pan paniscus</em>), together with human samples from Africa and Europe. We identified microbial taxonomic and functional adaptations convergent with host phylogeny at both the community and microbial genomic levels. We could show that repeated horizontal gene transfer and gene loss are processes involved in these adaptations. We hypothesize, that these adaptation processes and changes in the microbiome predispose the host to chronic inflammatory disorders, such as type 2 diabetes via altered histidine metabolism and inflammatory bowel disease indicated by adaptation of microbes to aerobic conditions. Additionally, we find multiple lines of evidence suggesting a widespread loss of microbial diversity and evolutionary conserved clades in the human microbiota, especially in the European population. Lastly, we observed patterns consistent with codivergence of hosts and microbes, particularly for the bacterial family <em>Dialisteraceae</em>, though we find that overall, co-phylogeny patterns are frequently disrupted in humans.</p>
SPAAM Summer School 2022: Introduction to Ancient Metagenomics - 5c Introduction to Functional Profiling
<p>Teaching data for practical session: "5c Introduction to Functional Profiling" of the 2022 SPAAM Summer School: Introduction to Ancient Metagenomics (Aug. 1-5 2022).</p> <p>See: <a href="https://spaam-community.github.io/wss-summer-school/#/2022/">https://spaam-community.github.io/wss-summer-school/#/2022/</a> or <a href="https://doi.org/10.5281/zenodo.6976711">https://doi.org/10.5281/zenodo.6976711</a> for slides.</p> <p>Once downloaded, run:</p> <pre><code>tar xvfz <session>.tar.gz</code></pre> <p> to decompress the data directory for the session.</p> <p>This updated version changes the conda environment due to versioning conflicts.</p>
Expanding the host-range of functional metagenomics reveals resistance threats to novel antibiotics
<p>Expanding the host-range of functional metagenomics reveals resistance threats to novel antibiotics. Sequences.</p>
Supplementary material 1 from: Graupner N, Boenigk J, Bock C, Jensen M, Marks S, Rahmann S, Beisser D (2017) Functional and phylogenetic analysis of the core transcriptome of Ochromonadales. Metabarcoding and Metagenomics 1: e19862. https://doi.org/10.3897/mbmg.1.19862
KEGG orthologous genes of the core trancriptome of the herein investigated Ochromonadales (Poteriospumella lacustris strains JBC07, JBM10, JBNZ41; Poterioochromonas malhamensis DS; Spumella vulgaris 199hm; Pedospumella encystans JBMS11) used for phylogenetic analyses.
Fueling ab initio folding with oceanic metagenomics enables structure and function predictions of new protein families
<p>Code and protein sequence database to construct multiple sequence alignment from Tara Ocean data.</p>
Supplementary material 1 from: Biessy L, Pearman JK, Waters S, Vandergoes MJ, Wood SA (2022) Metagenomic insights to the functional potential of sediment microbial communities in freshwater lakes. Metabarcoding and Metagenomics 6: e79265. https://doi.org/10.3897/mbmg.6.79265
Figures S1–S6
Supplementary material 2 from: Biessy L, Pearman JK, Waters S, Vandergoes MJ, Wood SA (2022) Metagenomic insights to the functional potential of sediment microbial communities in freshwater lakes. Metabarcoding and Metagenomics 6: e79265. https://doi.org/10.3897/mbmg.6.79265
Tables S1, S2
Data from: Cross-biome metagenomic analyses of soil microbial communities and their functional attributes
Open the record for dataset details and reuse information.
A metagenomic study revealing unexpectedly diverse functional groups in microbial communities of deep-ground oil
GEO Series GSE55293. Bacteria; uncultured bacterium. 9 samples. Type: Other.
Metagenomic analysis revealed higher microbial and functional gene diversities in deep landfill
GEO Series GSE68712. Bacteria. 15 samples. Type: Other.
Taxonomic and functional diversity of the microbiome in a jet fuel contaminated site as revealed by combined application of in situ microcosms with metagenomic analysis
<p>Natural attenuation represents all processes that govern contaminant mass removal, which mainly occurs via microbial degradation in the environment. Although this process is intrinsic its rate and efficiency depend on multiple factors. This study aimed to characterize the microbial taxonomic and functional diversity in different aquifer sediments collected in the saturated zone and <em>in situ</em> microcosms (BACTRAP®s) amended with hydrocarbons (<sup>13</sup>C-labeled and non-labeled benzene, toluene and naphthalene) using 16S rRNA gene and “<em>shotgun</em>” Illumina high throughput sequencing at a jet-fuel contaminated site. The BACTRAP®s were installed to assess hydrocarbon metabolism by native bacteria. Results indicated that Proteobacteria, Actinobacteria and Firmicutes were the most dominant phyla (~98%) in the aquifer sediment samples. Meanwhile, in the benzene- and toluene-amended BACTRAP®s the phyla Firmicutes and Proteobacteria accounted for about 90% of total community. In the naphthalene-amended BACTRAP®, members of the SR-FBR-L83 family (Order Ignavibacteriales) accounted for almost 80% of bacterial community. Functional annotation of metagenomes showed that only the sediment sample located at the source zone border and with the lowest BTEX concentration, has metabolic potential to degrade hydrocarbons aerobically. On the other hand, <em>in situ</em> BACTRAP®s allowed enrichment of hydrocarbon-degrading bacteria. Metagenomic data suggest that fumarate addition is the main mechanism for hydrocarbon activation of toluene. Also, indications for methylation, hydroxylation and carboxylation as activation mechanisms for benzene anaerobic conversion were found. After 120 days of exposure in the contaminated groundwater, the isotopic analysis of fatty acids extracted from BACTRAP®s demonstrated the assimilation of isotopic labeled compounds in the cells of microbes expressed by strong isotopic enrichment. We propose that the microbiota in this jet-fuel contaminated site has metabolic potential to degrade benzene and toluene by a syntrophic process, between members of the families Geobacteraceae and Peptococcaceae (genus <em>Pelotomaculum</em>), coupled to nitrate, iron and/or sulfate reduction.</p>
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.