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Dataset results
355 results for “functional programming”
Divergent molecular networks program functionally distinct CD8+ skin-resident memory T cells
<p>Skin-resident CD8+ T cells comprise distinct IFN-γ- (TRM1) and IL-17-producing (TRM17) subsets that differentially contribute to immune responses. However, whether these populations employ common mechanisms to establish tissue residence is unknown. Here, we show that TRM1 and TRM17 cells navigate divergent trajectories to acquire tissue residency in skin. While TRM1 cells depend on a T-bet-Hobit-IL-15 axis, TRM17 cells develop independently of these factors. Instead, c-Maf commands a tissue-resident program in TRM17 cells parallel to that induced by Hobit in TRM1 cells, with an ICOS-c-Maf-IL-7 axis pivotal to TRM17 cell commitment. Accordingly, targeting this pathway enables ablation of skin TRM17 cells without compromising their TRM1 counterparts. Thus, skin-resident T cells rely on distinct molecular circuitries, which can be exploited to strategically modulate local immunity.</p>
Implementing a Hospital-Based Walking Program (STRIDE): Function QUERI 2.0
ClinicalTrials.gov study NCT04868656. IPD Sharing: YES. Countries: 1. Publications: 2.
Implementing a Skills-Based Caregiver Training Program (Caregivers FIRST): Function QUERI 2.0
ClinicalTrials.gov study NCT05319535. IPD Sharing: YES. Countries: 1. Publications: 3.
Divergent molecular networks program functionally distinct CD8+ skin-resident memory T cells
Open the record for dataset details and reuse information.
Artifacts for the 2023 Trends in Functional Programming Publication: Versatile and Flexible Modelling of the RISC-V Instruction Set Architecture
<p>This dataset contains the artifacts for the performance evaluation conducted in the publication <em>Versatile and Flexible Modelling of the RISC-V Instruction Set Architecture</em> which will be published in the proceedings of the 2023 <em>Trends in Functional Programming</em> conference. The provided artifacts contain a <a href="https://docker.io">Docker</a> container for executing <a href="https://embench.org">Embench</a> benchmarks with LibRISCV, RISC-V VP, Grift and Forvis. A pre-built version of the container is included.</p>
Functional Exercise and Nutrition Education Program for Older Adults
ClinicalTrials.gov study NCT04037436. IPD Sharing: UNDECIDED. Countries: 1. Publications: 16.
Strength, Pain and Function in Operation Iraqi Freedom/Operation Enduring Freedom Amputees: A Nurse-Managed Program
ClinicalTrials.gov study NCT00942890. IPD Sharing: NO. Countries: 1. Publications: 2.
Telerehabilitation Program to Improve Function in People With Chronic Low Back Pain Compared With Conventional Care
ClinicalTrials.gov study NCT07248813. IPD Sharing: NO. Countries: 1. Publications: 4.
Trial of an Online Multimedia Program to Boost Coping & Function for Prostate Cancer Survivors (PROGRESS)
ClinicalTrials.gov study NCT02224482. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Prevention of Functional and Cognitive Impairment Through a Multicomponent Exercise Program in Hospitalized Older Adults
ClinicalTrials.gov study NCT06634147. IPD Sharing: YES. Countries: 1. Publications: 3.
Effect of a Multicomponent Exercise Program With Virtual Reality (MEP-VR) vs Standard Approaches on Functional and Cognitive Domains in Hospitalized Geriatric Patients: Study Protocol for a Randomized
ClinicalTrials.gov study NCT06469554. IPD Sharing: YES. Countries: 1. Publications: 1.
Home-based Digital Exercise Training Program to Improve Physical Function of Older Sepsis Survivors - HEAL Sepsis Trial
ClinicalTrials.gov study NCT05568511. IPD Sharing: NO. Countries: 1. Publications: 1.
Field and Home Exercise Program for Improving Function in Iraqi Rural Women
ClinicalTrials.gov study NCT07129356. IPD Sharing: YES. Countries: 1. Publications: 16.
Establishing Efficacy of a Functional-Restoration Based CAM Pain Management Program in Post-9/11 Veterans
ClinicalTrials.gov study NCT02657317. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A histone methyltransferase-independent function of PRC2 controls small RNA dynamics during programmed DNA elimination in Paramecium
<p><span lang="EN-US">To limit transposable element (TE) mobilization, most eukaryotes have evolved small RNAs to silence TE activity via homology-dependent mechanisms. Small RNAs, 20-30 nucleotides in length, bind to PIWI proteins and guide them to nascent transcripts by sequence complementarity, triggering the recruitment of histone methyltransferase enzymes on chromatin to repress the transcriptional activity of TEs and other repeats. In<span> the ciliate <em>Paramecium tetraurelia</em>,</span> 25-nt scnRNAs corresponding to TEs recruit Polycomb Repressive Complex 2 (PRC2), and trigger their elimination during the formation of the somatic nucleus. Here, we sequenced sRNAs during the entire sexual cycle with unprecedented resolution. Our data confirmed that scnRNAs are produced from the entire germline genome, from TEs and non-TE sequences, during meiosis. Non-TE scnRNAs are selectively degraded, which results in the specific selection of TE-scnRNAs. We demonstrate that PRC2 is essential for the selective degradation of non-TE-scnRNAs, independently of its histone methyltransferase activity. We further show that the PRC2 cofactor Rf4 mediates the physical interaction between the scnRNA-binding protein Ptiwi09 and the zinc finger protein Gtsf1, pointing to an architectural role of PRC2 in scnRNA degradation.</span></p>
Data from: Prenatal acoustic programming of mitochondrial function for high temperatures in an arid-adapted bird
<p>Sound is an essential source of information in many taxa and can notably be used by embryos to program their phenotypes for postnatal environments. While underlying mechanisms are mostly unknown, there is growing evidence for the implication of mitochondria – main source of cellular energy (<i>i.e.</i> ATP) – in developmental programming processes. Here, we tested whether prenatal sound programs mitochondrial metabolism. In the arid-adapted zebra finch, prenatal exposure to "heat-calls" – produced by parents incubating at high temperatures – adaptively alters nestling growth in the heat. We measured red blood cell mitochondrial function, in nestlings exposed prenatally to heat- or control-calls, and reared in contrasting thermal environments. Exposure to high temperatures always reduced mitochondrial ATP production efficiency. However, as expected to reduce heat production, prenatal exposure to heat-calls improved mitochondrial efficiency under mild heat conditions. In addition, when exposed to an acute heat-challenge, <i>LEAK</i> respiration was higher in heat-call nestlings, and mitochondrial efficiency low across temperatures. Consistent with its role in reducing oxidative damage, <i>LEAK</i> under extreme heat was also higher in fast-growing nestlings. Our study, therefore, provides the first demonstration of mitochondrial acoustic sensitivity, and brings us closer to understanding the underpinning of acoustic developmental programming and avian strategies for heat adaptation.</p>
A highly accurate and constrained density functional obtained with differentiable programming
<p>Set of data and codes needed to reproduce the manuscript : "A highly accurate and constrained density functional obtained with differentiable programming"</p>
Practical Course Report - Profiling and Tuning of Large Functional Programs
<p>Monomorphization extra materials.</p>
Challenges of ELA-based Function Evolution using Genetic Programming - Reproducability files
<p>This repository contains the data and code for the paper "Challenges of ELA-based Function Evolution using Genetic<br> Programming"</p> <p> </p> <p>This repository consists of separated folders, which contain the following data:</p> <p>## Code:</p> <p>This is the main code used to run the GP functions. The main executable is 'main_gp.py', which executes a single run of the GP system (based on the passed-in argument, which is an index from 0-71 in our experiments).</p> <p>The data for the BBOB functions are generated using the 'preliminary' folder and the 'get_ela_preliminary.py' file.</p> <p> </p> <p>## Data_GP:</p> <p>This contains the full logs from each GP run, separated by target function and dimension.</p> <p> </p> <p>## data_random_func:</p> <p>This contains the same kind of data but for the Random Function Generator.</p> <p> </p> <p>## Reproducibility:</p> <p>This contains all code used to analyse and visualize the resulting data. The notebook is structured in the same way as the paper, separated by figure.</p>
Effects of Lower Extremity Functional Exercise Program and Neuromuscular Electrical Nerve Stimulation in Older Adults
ClinicalTrials.gov study NCT07076797. IPD Sharing: NO. Countries: 1. Publications: 2.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.