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8 results for “gapdh”
GAPDH Purification
<p>Huntington’s Disease (HD) is a hereditary neurodegenerative disease; the cause of which is due to a CAG repeat extension in the HTT Gene. This extension is then translated into an elongation of exon 1 which is primarily composed of a disordered PolyQ repeat. Although the cause is known, the mechanism by which this extension affects the function of Huntingtin (HTT), the protein produced by the HTT Gene, has yet to be fully understood. A part of this difficulty is our lack of understanding of the role of normal HTT in our cells. To further our understanding of the role of HTT, we at the SGC have set out to explore the HTT interactome, which will give us a better idea of what specific interactions are modulated in HD. Our first step on this journey was to conduct a literature review alongside a BioID experiment to come up with a list of putative huntingtin interaction partners. One of the hits on the list was GAPDH. This means that we must obtain a pure sample of GAPDH for use in future experiments to further validate the claim that these proteins interact.</p>
Global analysis of off-target genes by GAPDH siRNA
GEO Series GSE41924. Homo sapiens. 3 samples. Type: Expression profiling by array.
Tensin 2 interactomics reveals interaction with GAPDH and a phosphorylation-mediated regulatory role in glycolysis
GEO Series GSE231782. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
GAPDH Controls Transcript Stability, Protein Translation and Drives Proliferation in Acute Myeloid Leukemia [CLIP-seq]
GEO Series GSE270168. Homo sapiens. 6 samples. Type: Other.
Gene profile in H1299 cells treated with PTD-DRBD GAPDH siRNA or treated with Lipofection GAPDH siRNA
GEO Series GSE15723. Homo sapiens. 12 samples. Type: Expression profiling by array.
GAPDH Controls Transcript Stability, Protein Translation and Drives Proliferation in Acute Myeloid Leukemia [GAPDH_KD_RNAseq]
GEO Series GSE270169. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Crotonylation of GAPDH regulates human embryonic stem cell endodermal lineage differentiation and metabolic switch
GEO Series GSE214619. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
ChIP-Seq for nuclear GAPDH in ex-vivo cortical microglia from LPS treated mice
GEO Series GSE155501. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
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