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396 results for “gastric bypass”
Glycemic patterns are distinct in individuals with post-bariatric hypoglycemia after gastric bypass (PBH-RYGB)
<p>While bariatric surgery can improve glycemia in type 2 diabetes (T2D), it can also result in severe hypoglycemia with neuroglycopenia, termed post-bariatric hypoglycemia (PBH). Hypoglycemia typically occurs postprandially but is also reported post-activity or mid-nocturnally.</p> <p>We used masked CGM (Dexcom G4) to quantify glycemia, glycemic variability (GV), and severity/length of low sensor glucose (SG) values in patients with PBH with prior Roux-en-Y gastric bypass (PBH-RYGB, n=40), and compared patterns to those from individuals with reactive hypoglycemia without GI surgery (Non-Surg Hypo, n=20) and to public data from healthy controls (HC, n=38) and individuals with pre-diabetes (Pre-DM, n=14), and newly-diagnosed T2D (n=5). Data were assessed over 24 hours, daytime (6 AM to midnight) and nighttime (midnight to 6 AM).</p> <p>Mean and median SG were similar for PBH-RYGB and HC (mean: 99.8±18.6 vs. 96.9±10.2 mg/dL; median: 93.0±14.8 vs. 94.5±7.4 mg/dL). By contrast, PBH-RYGB had a higher coefficient of variation (27.3±6.8 vs. 17.9±2.4%, p<0.0001) and wider range (154.5±50.4 vs. 112.0±26.7 mg/dL, p<0.0001). Nadir was lowest in PBH-RYGB (42.5±3.7 vs. HC 49.0±11.9 mg/dL, p=0.0046), with >2-fold greater time with SG<70 mg/dL vs. HC (7.7±8.4 vs. 3.2±4.1%, p=0.0013); these differences were even greater at night (12.6±16.9 vs. 1.0±1.5%, p<0.0001). Non-Surg Hypo also had 4-fold greater time with SG<70 at night vs. HC (SG <70: 4.0 ± 5.9% vs 1.0 ± 1.5%), but glycemic variability was not increased in this group.</p> <p>Patients with PBH-RYGB experience higher glycemic variability and frequency of SG<70 compared to HC, especially at night. These data suggest that additional pathophysiologic mechanisms beyond prandial changes contribute to PBH.</p>
Laparoscopic Gastric Bypass vs LAP-BAND for Treatment of Morbid Obesity
ClinicalTrials.gov study NCT00247377. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Clinical and Economic Outcomes in Laparoscopic Sleeve Gastrectomy Versus Roux-en-Y Gastric Bypass Surgery
ClinicalTrials.gov study NCT01754194. IPD Sharing: Not stated. Countries: 1. Publications: 1.
GAstric Bypass to Treat obEse Patients With steAdy hYpertension
ClinicalTrials.gov study NCT01784848. IPD Sharing: UNDECIDED. Countries: 1. Publications: 6.
Benefits of Opioid Free Anesthesia on Morphine Consumption in Gastric Bypass
ClinicalTrials.gov study NCT05004519. IPD Sharing: NO. Countries: 1. Publications: 1.
Comparison of One Anastomisis Gastric Bypass and Duodeno-Jejunostomy for Treating SMA Syndrome
ClinicalTrials.gov study NCT06970093. IPD Sharing: YES. Countries: 1. Publications: 5.
Study on the Use of Low Dose Ketamine After Gastric Bypass and Gastrectomy
ClinicalTrials.gov study NCT02452060. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects on Remission of Type 2 Diabetes Mellitus Following Gastric Bypass Alone vs Gastric Bypass Combined With Truncal Vagotomy
ClinicalTrials.gov study NCT07278115. IPD Sharing: YES. Countries: 1. Publications: 2.
Determinants of Diabetes Remission After Gastric Bypass Surgery
ClinicalTrials.gov study NCT02287285. IPD Sharing: YES. Countries: 1. Publications: 2.
Incisionless Treatment for Patients With Inadequate Weight Loss Following Roux-en-Y Gastric Bypass
ClinicalTrials.gov study NCT00394212. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Low-calorie Diet and Body Composition Prior to Roux-en-Y Gastric Bypass
ClinicalTrials.gov study NCT02144597. IPD Sharing: NO. Countries: 1. Publications: 0.
Effects of Gastric Bypass Surgery and Calcium Metabolism and the Skeleton
ClinicalTrials.gov study NCT01330914. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Gastroesophageal Reflux Disease (GERD) Before and After Gastric Bypass
ClinicalTrials.gov study NCT00951093. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Pramlintide (Symlin) for the Treatment of Hypoglycemia Following Gastric Bypass Surgery
ClinicalTrials.gov study NCT01841359. IPD Sharing: Not stated. Countries: 1. Publications: 4.
The Effect of Pre-Operative Transversus Abdominis Plane (TAP) Block in the Post Operative Opioid Consumption in Morbid Obese Patients Undergoing Laparoscopic Gastric Bypass Surgery: A Prospective,Rand
ClinicalTrials.gov study NCT01075087. IPD Sharing: Not stated. Countries: 1. Publications: 11.
Randomized Comparison of Laparoscopic Sleeve Gastrectomy and Gastric Bypass for Morbid Obesity
ClinicalTrials.gov study NCT01806506. IPD Sharing: NO. Countries: 1. Publications: 1.
Glycemic patterns are distinct in individuals with post-bariatric hypoglycemia after gastric bypass (PBH-RYGB)
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Data from: Anemia and related nutrient deficiencies after Roux-en-Y gastric bypass surgery: a systematic review and meta-analysis
Objective: To obtain a pooled risk estimate on the long-term impact of anaemia and related nutritional deficiencies in patients receiving Roux-en-Y gastric bypass (RYGB) surgery. Design: Systematic review and meta-analysis. Data sources: MEDLINE, EMBASE and Cochrane databases were searched to identify English reports published before 16 May 2014. Eligibility criteria: Articles with case numbers >100, follow-up period >12 months, and complete data from both before and after surgery were selected. Outcomes of interest were changes in baseline measurements of proportion of patients with anaemia, by haemoglobin, haematocrit, ferritin, iron, vitamin B12 and folate levels. Data collection and analysis: Two reviewers independently reviewed data and selected six prospective and nine retrospective studies with a total of 5909 patients. A random effect model with inverse variance weighting was used to calculate summary estimates of outcomes at 6, 12, 24 and 36 months postoperatively. Results: Proportion of patients with anaemia was 12.2% at baseline, which, respectively, increased to 20.9% and 25.9% at 12 and 24 months follow-up, consistent with decreases in haemoglobin and haematocrit levels. Although the serum iron level did not change substantially after surgery, the frequency of patients with ferritin deficiency increased from 7.9% at baseline to 13.4% and 23.0% at 12 and 24 months, respectively, postoperation. Vitamin B12 deficiency increased from 2.3% at baseline to 6.5% at 12 months after surgery in those subjects receiving RYGB. There was no obvious increase in folate deficiency. Conclusions: RYGB surgery is associated with an increased risk of anaemia and deficiencies of iron and vitamin B12, but not folate. Ferritin is more sensitive when serum iron level is within normal range.
Study on the Performance of Symmcora® Mid-term Suture Versus Novosyn® Suture in Patients Undergoing Robotic Assisted Gastric Bypass Surgery
ClinicalTrials.gov study NCT05433688. IPD Sharing: NO. Countries: 1. Publications: 1.
Pharmacokinetic Evaluation of Moxifloxacin Administered Intravenously and Orally in Healthy Volunteers Who Have Had a Gastric Bypass
ClinicalTrials.gov study NCT01130922. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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