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161 results for “genetic susceptibility”
Data from: Genetic susceptibility, Mendelian randomization and nomogram model construction of gestational diabetes mellitus
<p>The dataset contains subjects' basic information, including the Identification number of the test sample, fasting plasma glucose (FPG), oral glucose tolerance test 1h plasma glucose (1hPG), oral glucose tolerance test 2h plasma glucose (2hPG), glycated hemoglobin (HbA1c), Systolic blood pressure (SBP), Diastolic blood pressure (DBP), triglyceride (TG), total cholesterol (TC), High-density lipoprotein cholesterol (HDL-c), Low-density lipoprotein cholesterol (LDL-c), and also involves subjects' genetic variant information used for analysis of the association of functional polymorphisms and GDM. The variables including SBP_M, DBP_M, FPG_M, 1hPG_M, 2hPG_M, HbA1c_M, TG_M represent the mean value of SBP, DBP, FPG, 1hPG, 2hPG, HbA1c, TG, which are used for the stratification analysis. This study has obtained the support from the Ethics Committee of Guilin Medical University. All included subjects signed the informed consent.</p>
Challenging a host-pathogen paradigm: Susceptibility to chytridiomycosis is decoupled from genetic erosion
<p>The putatively positive association between host genetic diversity and the ability to defend against pathogens has long attracted the attention of evolutionary biologists. Chytridiomycosis, a disease caused by the chytrid fungus <em>Batrachochytrium dendrobatidis</em> (<em>Bd</em>), has emerged in recent decades as a cause of dramatic declines and extinctions across the amphibian clade. Bd susceptibility can vary widely across populations of the same species, but the relationship between standing genetic diversity and susceptibility has remained notably underexplored so far. Here, we focus on a putatively <em>Bd</em>-naive system of two mainland and two island populations of the common toad (<em>Bufo bufo</em>) at the edge of the species' range, and use controlled infection experiments and dd-RAD sequencing of >10,000 SNPs across 95 individuals to characterise the role of host population identity, genetic variation and individual body mass in mediating host response to the pathogen. We found strong genetic differentiation between populations and marked variation in their susceptibility to Bd. This variation was not, however, governed by isolation-mediated genetic erosion, and individual heterozygosity was even found to be negatively correlated with survival. Individual survival during infection experiments was strongly positively related to body mass, which itself was unrelated to population of origin or heterozygosity. Our findings underscore the general importance of context-dependency when assessing the role of host genetic variation for the ability of defence against pathogens.</p>
Data from Preliminary estimates of genetic parameters and familial selection for non-native poplars show good potential for genetic gains on growth, cold hardiness, trunk quality and Sphaerulina musiva susceptibility
<p>Data from Preliminary estimates of genetic parameters and familial selection for non-native poplars show good potential for genetic gains on growth, cold hardiness, trunk quality and <em>Sphaerulina musiva</em> susceptibility</p> <p><br> Abstract<br> Genetic parameters for growth, trunk quality and susceptibility to frost and <em>Sphaerulina musiva</em> attack was estimated from 34 half-sib families of hybrid poplar from the crossing of non-native parents, <em>Populus maximowiczii</em> A. Henry and <em>Populus trichocarpa</em> Torr. & Gray, 3 and 6 years after planting. The use of spatial analysis proved to be the best method for quantitative growth data. The proportion of the among-family variance to the total (phenotypic) variance as well as the high heritabilities of growth and susceptibility to frost and <em>Spaherulina musiva</em> showed a high potential for selection for these traits while the quality traits were under low genetic control. Some families showed gains for several traits, suggesting the possibility of developing a selection index to obtain superior families that show gain for not only growth but quality and adaptive traits as well. Type B correlations were high, suggesting that families responded in the same way regardless of the site. High type A correlation between growth traits at 3 and 6 years showed early selection potential, although these relationships should be confirmed with future measurements to evaluate this effect at maturity. These results can be integrated into the strategy for improving hybrid poplar parental populations and, in the longer term, will make it possible to optimize the selection of individuals with traits of interest for the operational deployment of hybrid poplar clones.</p>
Oral Infigratinib for the Adjuvant Treatment of Subjects With Invasive Urothelial Carcinoma With Susceptible FGFR3 Genetic Alterations
ClinicalTrials.gov study NCT04197986. IPD Sharing: NO. Countries: 11. Publications: 2.
Challenging a host-pathogen paradigm: Susceptibility to chytridiomycosis is decoupled from genetic erosion
Open the record for dataset details and reuse information.
Data from: Genetic susceptibility, Mendelian randomization and nomogram model construction of gestational diabetes mellitus
Open the record for dataset details and reuse information.
Data from: Genome-wide exon-capture approach identifies genetic variants of Norway spruce genes associated with susceptibility to Heterobasidion parviporum infection
Root and butt rot caused by members of the Heterobasidion annosum species complex is the most economically important disease of conifer trees in boreal forests. Wood decay in the infected trees dramatically decreases their value and causes considerable losses to forest owners. Trees vary in their susceptibility to Heterobasidion infection, but the genetic determinants underlying the variation in the susceptibility are not well-understood. We performed the identification of Norway spruce genes associated with the resistance to Heterobasidion parviporum infection using genome-wide exon-capture approach. Sixty-four clonal Norway spruce lines were phenotyped, and their responses to H. parviporum inoculation were determined by lesion length measurements. Afterwards, the spruce lines were genotyped by targeted resequencing and identification of genetic variants (SNPs). Genome-wide association analysis identified 10 SNPs located within 8 genes as significantly associated with the larger necrotic lesions in response to H. parviporum inoculation. The genetic variants identified in our analysis are potential marker candidates for future screening programs aiming at the differentiation of disease-susceptible and resistant trees.
Genetic basis of growth, spring phenology and susceptibility to biotic stressors in maritime pine
<p>Forest ecosystems are increasingly challenged by extreme events, e.g. drought, storms, pest and pathogenic fungi outbreaks, causing severe ecological and economical losses. Understanding the genetic basis of adaptive traits in tree species is of key importance to preserve forest ecosystems, as genetic variation in a trait (i.e. heritability) determines its potential for human-mediated or evolutionary change. Maritime pine (<i>Pinus pinaster</i> Aiton), a conifer widely distributed in southwestern Europe and northwestern Africa, grows under contrasted environmental conditions promoting local adaptation. Genetic variation at adaptive phenotypes, including height, growth phenology and susceptibility to two fungal pathogens (<i>Diplodia sapinea</i> and <i>Armillaria ostoyae</i>) and an insect pest (<i>Thaumetopoea pityocampa</i>), were assessed in a range-wide clonal common garden of maritime pine. Broad-sense heritability was significant for height (0.219), growth phenology (0.165-0.310) and pathogen susceptibility (necrosis length caused by <i>D. sapinea</i>, 0.152; and by <i>A. ostoyae</i>, 0.021) measured after inoculation under controlled conditions, but not for pine processionary moth incidence in the common garden. The correlations of trait variation among populations revealed contrasting trends for pathogen susceptibility to <i>D. sapinea</i> and <i>A. ostoyae</i> with respect to height. Taller trees showed longer necrosis length caused by <i>D. sapinea </i>while shorter trees were more affected by <i>A. ostoyae</i>. Moreover, maritime pine populations from areas with high summer temperatures and frequent droughts were less susceptible to <i>D. sapinea </i>but more susceptible to <i>A. ostoyae</i>. Finally, an association study using 4,227 genome-wide SNPs revealed several loci significantly associated to each trait (range of 3-26), including a possibly disease-induced translation initiation factor, eIF-5. This study provides important insights to develop genetic conservation and breeding strategies integrating species responses to biotic stressors.</p>
Genetic mutations and decreased protein expression of ABCG2 urate transporters are associated with susceptibility to gout, disease severity and renal-overload hyperuricemia
<p><strong>We are releasing the data and code of our study of clinically defined gouty patients. </strong></p>
The impact of genetic variants in the CYP2C8 gene on bladder cancer susceptibility 1 Short Title:Genetic variants on bladder cancer
<p>Four SNPs including rs1934953, rs1934951, rs2275620, and rs17110453 in the CYP2C8 gene were selected and determined in 550 healthy subjects and 217 bladder cancer patients. SNPs genotyping was determined using Agena MassARRAY iPLEX platform.</p>
FIGURES 1–2 in High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
FIGURES 1–2. Helichus cordubensis: 1, male genitalia, ventral view; 2, lateral view of same. Locality of specimen used for the illustration: "Alta Gracia, La Granja. Sierra de Córdoba, Cordoba province, Argentina".
Multi-ancestry meta-analysis of host genetic susceptibility to tuberculosis identifies shared genetic architecture
<p><span>The heritability of susceptibility to tuberculosis disease (TB) has been well recognized. Over one-hundred genes have been studied as candidates for TB susceptibility, and several variants were identified by genome-wide association studies (GWAS), but few replicates. We established the International Tuberculosis Host Genetics Consortium (ITHGC) to perform a multi-ancestry meta-analysis of GWAS including 14,153 cases and 19,536 controls of African, Asian, and European ancestry. Our analyses demonstrate a substantial degree of heritability (pooled polygenic h<sup>2</sup>=26.3% 95% CI 23.7–29.0%) for susceptibility to TB that is shared across ancestries, highlighting an important host genetic influence on disease. We identified one global host genetic correlate for TB at genome-wide significance (p < 5x10<sup>-8</sup>) in the human leukocyte antigen (HLA)-II region (rs28383206, p-value = 5.2x10<sup>-9</sup>). These data demonstrate the complex shared genetic architecture of susceptibility to TB and the importance of large-scale GWAS analysis across multiple ancestries experiencing different levels of infection pressures. </span></p>
Genetic Clues to Chordoma Etiology: A Protocol to Identify Sporadic Chordoma Patients for Studies of Cancer-Susceptibility Genes
ClinicalTrials.gov study NCT01200680. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Genetic Susceptibility to Oncogenic Viruses
ClinicalTrials.gov study NCT00341484. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Genetic Susceptibility to Cardiovascular Disease in Patients on Kidney Dialysis
ClinicalTrials.gov study NCT00340119. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Combined Aerobic Exercise and Cognitive Training in Seniors With Genetic Susceptibility for Alzheimer's Disease
ClinicalTrials.gov study NCT05163067. IPD Sharing: NO. Countries: 1. Publications: 5.
Genetic Susceptibility to Radiation-Induced Skin Reactions in Racial/Ethnic Groups of Patients With Breast Cancer
ClinicalTrials.gov study NCT01407770. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Genetic Susceptibility to Factor VIII Inhibitors
ClinicalTrials.gov study NCT00344435. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Study of Neurobiological Predictors of Response to Non-invasive Neurostimulation and Genetic Susceptibility to Dementia in Patients With Amnestic Mild Cognitive Impairment
ClinicalTrials.gov study NCT04943003. IPD Sharing: NO. Countries: 1. Publications: 0.
Mapping of End Stage Renal Disease Genetic Susceptibility in African Americans by Admixture Linkage Disequilibrium
ClinicalTrials.gov study NCT00559767. IPD Sharing: Not stated. Countries: 1. Publications: 3.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.