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83 results for “gentamicin”
Protective role of Pyrroloquinoline quinone against gentamicin induced cochlear hair cell ototoxicity
<p><strong>Abstract:</strong> Gentamicin(GM) is one of the commonly used antibiotics in the aminoglycoside class but ototoxicity as a side effect constantly impacts the quality of human life. Pyrroloquinoline quinone (PQQ) as a redox cofactor produced by bacteria was found in soil and foods that exert an antioxidant and redox modulator. It is well documented that the PQQ can alleviate inflammatory responses and cytotoxicity. However, our understanding of PQQ in ototoxicity remains unclear. We reported that PQQ could protect against GM-induced ototoxicity in House Ear Institute-Organ of Corti 1 (HEI-OC1) cells<em> in vitro</em>. To evaluate reactive oxygen species production and mitochondrial function, ROS and JC-1 staining, oxygen consumption rate (OCR), and extracellular acidification rate (ECAR) measurements in living cells, mitochondrial dynamics analysis was performed. GM-mediated damage by reducing the production of ROS and inhibiting mitochondria biogenesis and dynamics. PQQ ameliorated the cellular oxidative stress, and recovered mitochondrial membrane potential, facilitating the recovery of mitochondrial biogenesis and dynamics. Our <em>in vitro</em> findings improve our understanding of GM-induced ototoxicity with therapeutic implications for PQQ.</p>
Gentamicin in Preventing Post Endoscopic Retrograde Cholangiopancreatography (ERCP) Cholangitis in Non-calculus Stenting
ClinicalTrials.gov study NCT01148693. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Gentamicin Intravesical Efficacy for Infection of Urinary Tract
ClinicalTrials.gov study NCT04246996. IPD Sharing: NO. Countries: 1. Publications: 1.
Pilot RCT Local Gentamicin for Open Tibial Fractures in Tanzania
ClinicalTrials.gov study NCT03559400. IPD Sharing: NO. Countries: 1. Publications: 1.
Bronchoscopic Levofloxacin, Gentamicin, or Sham for Acute Exacerbation of Bronchiectasis
ClinicalTrials.gov study NCT06209047. IPD Sharing: YES. Countries: 1. Publications: 6.
Pharmacokinetics, Safety, and Efficacy Trial of WR 279,396 (Paromomycin + Gentamicin Topical Cream) and Paromomycin Topical Cream for the Treatment of Cutaneous Leishmaniasis in Panama
ClinicalTrials.gov study NCT01083576. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Transtympanic Gentamicin vs. Steroids in Refractory Meniere's Disease
ClinicalTrials.gov study NCT00802529. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Ampicillin / Sulbactam vs. Ampicillin / Gentamicin for Treatment of Chorioamnionitis
ClinicalTrials.gov study NCT00879190. IPD Sharing: NO. Countries: 1. Publications: 0.
Gentamicin Treatment Prior to Schwannoma Surgery - No Residual Function
ClinicalTrials.gov study NCT02415257. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Optimizing IV Gentamicin in JEB
ClinicalTrials.gov study NCT04140786. IPD Sharing: NO. Countries: 1. Publications: 1.
Effect of Gentamicin Lavage of the Axillary Surgical Bed After Lymph Node Dissection on Drainage Discharge Volume
ClinicalTrials.gov study NCT01700504. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy and Complication of Gentamicin Nasal Irrigation in Chronic Rhinosinusitis
ClinicalTrials.gov study NCT01430026. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Evaluation of the Efficacy of Prophylactic Topical Gentamicin in Tunnelled Catheters for Hemodialysis
ClinicalTrials.gov study NCT04967859. IPD Sharing: NO. Countries: 1. Publications: 10.
Long Term Nebulised Gentamicin in Patients With Bronchiectasis
ClinicalTrials.gov study NCT00749866. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Gentamicin Open Tibia Study
ClinicalTrials.gov study NCT05157126. IPD Sharing: NO. Countries: 1. Publications: 1.
Gentamicin in Cardiac Surgery
ClinicalTrials.gov study NCT06454643. IPD Sharing: NO. Countries: 1. Publications: 2.
Sativex® and Gentamicin for Optimized Pharmagological Treatment in Older Patients (CanPan)
ClinicalTrials.gov study NCT05503147. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Local Gentamicin Application to Reduce Postoperative Infection Rate
ClinicalTrials.gov study NCT01287780. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Is Self-transfusion Safe After Total Knee Arthroplasty in Terms of Nephrotoxicity of Gentamicin From Bone Cement?
ClinicalTrials.gov study NCT04505748. IPD Sharing: NO. Countries: 1. Publications: 4.
Gentamicin Therapy for Recessive Dystrophic Epidermolysis Bullosa (RDEB) Nonsense Mutation Patients
ClinicalTrials.gov study NCT02698735. IPD Sharing: Not stated. Countries: 0. Publications: 1.
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OpenNeuro
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