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777 results for “germ cells”
Centripetal migration in Drosophila ovary IX: E-cadherin null clones pt2 & E-Cadherin germ cell RNAi pt 2
<p>Part of data supporting Figs 6, 7, S3, S6, S16 of “Two phases for centripetal migration of Drosophila melanogaster follicle cells: initial ingression followed by epithelial migration”<br> DOI: 10.1242/dev.200492</p> <p><strong>Data file descriptions:</strong></p> <ul> <li><strong>“FRT G13 mitotic clones” 14.6 GB</strong></li> </ul> <p> Fixed sample image data for clones of cells with E-Cadherin mutant or control mitotic clones</p> <ul> <li><strong>“GC RNAi flipout timelapse data pt2” 28.92GB</strong></li> </ul> <p> Timelapse image data for clones of germ cells with E-Cadherin knockdown</p> <ul> <li><strong> “Image analysis of ring canals-fixed G13 control” 6 KB</strong></li> </ul> <p> Evaluation of fixed samples for ring canal position just prior to stage 11, nurse cell dumping, using</p> <ul> <li><strong>“Immuno Shg LOF clonal analysis” 98 KB</strong></li> </ul> <p> Preliminary evaluation of sample image with clones of cells with E-Cadherin mutant or control mitotic clones</p> <ul> <li><strong>“Live GC RNAi clonal data Prelim Eval” 25.2 MB</strong></li> </ul> <p> Preliminary evaluation of germ cell E-Cadherin knockdown samples</p> <p> </p>
Centripetal migration in Drosophila ovary X: E-Cadherin germ cell RNAi pt 1
<p>Part of data supporting Fig S16 of “Two phases for centripetal migration of Drosophila melanogaster follicle cells: initial ingression followed by epithelial migration”</p> <p>DOI: 10.1242/dev.200492</p> <p>Data description:</p> <ul> <li><strong>“GC RNAi flipout timelapse data pt1” 38 GB</strong></li> </ul> <p> Timelapse image data for clones of germ cells with E-Cadherin knockdown</p> <ul> <li><strong>“Live GC RNAi clonal data Prelim Eval” 25.2 MB</strong></li> </ul> <p> Preliminary evaluation of all germ cell E-Cadherin knockdown samples</p>
FMPP and Testicular Germ Cell Tumors - Supplementary Data
<p>Objective: The purpose of this study is to report development of a malignant testicular<br> germ cell tumor (GCT) in two young adult males with Familial Male-limited Precocious<br> Puberty (FMPP) due to (LHCGR) pathogenic variants in two families. Secondary, to<br> study the possible relation between FMPP and testicular tumors and to investigate<br> whether FMPP might predispose to development of malignant testicular tumors in<br> adulthood a literature review is conducted. Methods: Data on six cases in two families<br> are obtained from the available medical records. In addition, a database search is<br> performed in Cochrane, Pubmed and Embase for studies that report on a possible link<br> between FMPP and testicular tumors. Results: The characteristics of six males with<br> FMPP based on activating luteinizing hormone receptor (LHCGR) germline pathogenic<br> variants are described, as well as details of the testicular GCTs. Furthermore, literature<br> review identified four more patients with signs of FMPP and a (precursor of a) testicular<br> GCT in adolescence or adulthood (age 15 to 35 years). Additionally, twelve patients<br> with signs of precocious puberty and, simultaneously, occurrence of a Leydig cell<br> adenoma or Leydig cell hyperplasia are reported. Conclusion: There is a strong<br> suggestion that FMPP might increase the risk of development of testicular GCTs in<br> early adulthood compared to the risk in the general population. Therefore, prolonged<br> patient monitoring from mid-pubertal age onwards including instruction for selfexamination<br> and periodic testicular ultrasound investigation in patients with a<br> germline LHCGRpathogenic variants might contribute to early detection and thus early<br> treatment of testicular GCT.</p> <p>This files contains the supplementary data. </p>
Data from: Caenorhabditis elegans germ granules accumulate hundreds of low translation mRNAs with no systematic preference for germ cell fate regulators
<p>In animals with germ plasm, embryonic germline precursors inherit germ granules, condensates proposed to regulate mRNAs coding for germ cell fate determinants. In <em>C. elegans</em>, mRNAs are recruited to germ granules by MEG-3, a sequence non-specific RNA-binding protein that forms stabilizing interfacial clusters on germ granules. Using fluorescent <em>in situ </em>hybridization, we confirmed that 441 MEG-3-bound transcripts distribute in a pattern consistent with enrichment in germ granules. 13 are related to transcripts reported in germ granules in <em>Drosophila</em> or <em>Nasonia</em>. The majority, however, are low-translation maternal transcripts required for embryogenesis that are not maintained preferentially in the nascent germline. Granule enrichment raises the concentration of certain transcripts in germ plasm but is not essential to regulate mRNA translation or stability. Our findings suggest that only a minority of germ granule-associated transcripts contribute to germ cell fate in <em>C. elegans</em> and that the vast majority function as non-specific scaffolds for MEG-3.</p>
Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors
ClinicalTrials.gov study NCT00047320. IPD Sharing: Not stated. Countries: 5. Publications: 1.
High-dose Chemotherapy for Poor-Prognosis Relapsed Germ-Cell Tumors
ClinicalTrials.gov study NCT00936936. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Sunitinib Malate in Refractory Germ Cell Tumors
ClinicalTrials.gov study NCT00912912. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Germ Cell Tumors
ClinicalTrials.gov study NCT00002558. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Aprepitant + a 5HT3 + Dexamethasone in Patients With Germ Cell Tumors
ClinicalTrials.gov study NCT00572572. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study to Assess the Safety and Efficacy of ASP1650, a Monoclonal Antibody Targeting Claudin 6 (CLDN6), in Male Subjects With Incurable Platinum Refractory Germ Cell Tumors
ClinicalTrials.gov study NCT03760081. IPD Sharing: NO. Countries: 1. Publications: 1.
Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignan
ClinicalTrials.gov study NCT00716976. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Fosaprepitant + 5HT3 Receptor Antagonists + Dexamethasone in Germ Cell Tumors
ClinicalTrials.gov study NCT01736917. IPD Sharing: NO. Countries: 1. Publications: 1.
Pembrolizumab in Subjects With Incurable Platinum-Refractory Germ Cell Tumors
ClinicalTrials.gov study NCT02499952. IPD Sharing: NO. Countries: 1. Publications: 1.
Chemotherapy Followed by Radiation Therapy in Treating Younger Patients With Newly Diagnosed Localized Central Nervous System Germ Cell Tumors
ClinicalTrials.gov study NCT01602666. IPD Sharing: Not stated. Countries: 5. Publications: 1.
Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment
ClinicalTrials.gov study NCT00453310. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors
ClinicalTrials.gov study NCT00104676. IPD Sharing: NO. Countries: 3. Publications: 2.
Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors
ClinicalTrials.gov study NCT00053352. IPD Sharing: Not stated. Countries: 6. Publications: 1.
Data from: Caenorhabditis elegans germ granules accumulate hundreds of low translation mRNAs with no systematic preference for germ cell fate regulators
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prg-1 longevity germline nucleoli: Piwi mutant germ cells transmit a form of heritable stress that promotes longevity
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Data from: Caspar specifies primordial germ cell count and identity in Drosophila melanogaster
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Allen Brain Atlas
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International Brain Laboratory public data
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OpenNeuro
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