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65 results for “glucose intolerance”
Mifepristone Effects on Glucose Intolerance in Obese/Overweight Adults
ClinicalTrials.gov study NCT01419535. IPD Sharing: YES. Countries: 1. Publications: 4.
Comparative Evaluation of Body Mass Index, Waist Circumference and Waist-To-Hip Ratio as Correlates of Glucose Intolerance among Rural Dwellers in Nigeria
<p>This research investigates the comparative efficacy of Body Mass Index (BMI), Waist Circumference (WC), and Waist-to-Hip Ratio (WHR) as correlates of glucose intolerance among rural dwellers in Nigeria. Conducted as a descriptive cross-sectional study in Oyo State, Nigeria, the research involved adults aged 18 years and above. The study employed a multi-stage cluster sampling technique, selecting participants from rural communities. Exclusion criteria included pregnant women and those with known diabetes or medications affecting glucose metabolism. Anthro-pometric indices and blood glucose levels were determined using Hanson's weighing scale, a meter rule, and biochemical auto-analyzers. The BMI, WC, and WHR were utilized to assess obesity and abdominal adiposity. Blood glucose levels were measured for fasting and 2-hour post-prandial samples. Data analysis involved descriptive statistics and chi-square tests using SPSS version 26. Results from the study revealed demographic characteristics and medical history of participants. Findings indicated a significant association between anthropometric parameters and gender. Notably, WHR exhibited a strong correlation with glucose intolerance, emphasizing its potential as a predictor. The study also presented the correlation of BMI, WC, and WHR with blood glucose levels, categorizing participants into different risk groups based on these indices. This research contributes valuable insights into the effectiveness of BMI, WC, and WHR in predicting glucose intolerance among rural dwellers in Nigeria. The findings underscore the importance of tailored interventions for specific populations, considering regional variations in health determinants. Future research can build upon these results to develop targeted strategies for diabetes prevention and management in rural communities.</p>
The Significance of Glucose Intolerance in the Pathogenesis of Idiopathic Axonal Polyneuropathy
ClinicalTrials.gov study NCT00228345. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Mobile-based Lifestyle Intervention in Women With Glucose Intolerance After Gestational Diabetes
ClinicalTrials.gov study NCT03559621. IPD Sharing: NO. Countries: 1. Publications: 1.
Novel Therapy for Glucose Intolerance in HIV Disease
ClinicalTrials.gov study NCT02006914. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Probiotics (Lactobacillus Rhamnosus) in Reducing Glucose Intolerance During and After Pregnancy
ClinicalTrials.gov study NCT01436448. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Paleolithic Diet in the Treatment of Glucose Intolerance
ClinicalTrials.gov study NCT00419497. IPD Sharing: NO. Countries: 1. Publications: 2.
Rosiglitazone to Treat Patients With Heart Failure and Glucose Intolerance or Type II Diabetes
ClinicalTrials.gov study NCT00064727. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Is Insulin Resistance and/or Glucose Intolerance Pathogenetic in the Development of a Reduced Incretin Effect
ClinicalTrials.gov study NCT00784745. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Comparison of Eplerenone Versus Spironolactone in Heart Failure Patients With Glucose Intolerance or Type 2 Diabetes
ClinicalTrials.gov study NCT01586442. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Comparison of Valsartan With Amlodipine in Hypertensive Patients With Glucose Intolerance
ClinicalTrials.gov study NCT00129233. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Exposure to low doses of Dechlorane Plus promotes adipose tissue dysfunction and glucose intolerance in mice
<p>The prevalence of type 2 diabetes (T2D) continues to increase worldwide. It is well established that genetic susceptibility, obesity, overnutrition and a sedentary life style are risk factors for the development of T2D. However, more recently, studies have also proposed links between exposure to endocrine-disrupting chemicals (EDCs) and altered glucose metabolism. Human exposure to environmental pollutants suspected to have endocrine disruptor activity is ubiquitous. One such chemical is Dechlorane Plus, a flame retardant, that is now detected in humans and the environment. Here we show that exposure of mice to low, environmentally relevant doses of Dechlorane Plus (DP), promoted glucose intolerance in mice fed high fat diet independent of weight gain. Further, DP had pronounced effects on the adipose tissue, where it induced the development of hypertrophied white adipose tissue (WAT), and increased serum levels of resistin, leptin, and plasminogen activator inhibitor-1. Further, DP exposure induced "whitening" of brown adipose tissue (BAT), and reduced BAT <i>uncoupling protein 1</i> expression. Importantly, some of these effects occurred even when the mice were fed regular, low fat, diet. Finally, WAT adipogenic markers were reduced with DP treatment in the WAT. We also show that, DP directly inhibited insulin signalling in murine adipocytes and human primary subcutaneous adipocytes <i>in vitro</i>. Taken together, our results show that the exposure to low and environmentally relevant levels of DP may contribute to the development of T2D.</p>
Data from: Intestinal Ralstonia pickettii augments glucose intolerance in obesity
An altered intestinal microbiota composition has been implicated in the pathogenesis of metabolic disease including obesity and type 2 diabetes mellitus (T2DM). Low grade inflammation, potentially initiated by the intestinal microbiota, has been suggested to be a driving force in the development of insulin resistance in obesity. Here, we report that bacterial DNA is present in mesenteric adipose tissue of obese but otherwise healthy human subjects. Pyrosequencing of bacterial 16S rRNA genes revealed that DNA from the Gram-negative species Ralstonia was most prevalent. Interestingly, fecal abundance of Ralstonia pickettii was increased in obese subjects with pre-diabetes and T2DM. To assess if R. pickettii was causally involved in development of obesity and T2DM, we performed a proof-of-concept study in diet-induced obese (DIO) mice. Compared to vehicle-treated control mice, R. pickettii-treated DIO mice had reduced glucose tolerance. In addition, circulating levels of endotoxin were increased in R. pickettii-treated mice. In conclusion, this study suggests that intestinal Ralstonia is increased in obese human subjects with T2DM and reciprocally worsens glucose tolerance in DIO mice.
GLP-1 Agonist Therapy in Cystic Fibrosis-Related Glucose Intolerance
ClinicalTrials.gov study NCT04731272. IPD Sharing: YES. Countries: 1. Publications: 0.
Effect of Artemisia Dracunculus on Glucose Intolerance, Insulin Sensitivity and Insulin Secretion
ClinicalTrials.gov study NCT02330341. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Vyvanse and Glucose Intolerance in Children With Attention Deficit Hyperactivity Disorder (ADHD) and Obesity
ClinicalTrials.gov study NCT01017263. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Cardiovascular Disease (CVD) Risk and Prevention in Early Glucose Intolerance
ClinicalTrials.gov study NCT00122447. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Exposure to low doses of Dechlorane Plus promotes adipose tissue dysfunction and glucose intolerance in mice
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Data from: Intestinal Ralstonia pickettii augments glucose intolerance in obesity
Open the record for dataset details and reuse information.
Distinct blood CD3+ CD14+ T Cell-Monocyte complexes harbor HIV and are dynamic, glucose-dependent and increased in individuals with glucose intolerance
GEO Series GSE230276. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
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International Brain Laboratory public data
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OpenNeuro
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