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185 results for “glutathione”
Hemoglobin as oxygen-dependent glutathione buffer
<p>This dataset is associated with the pre-print "Hemoglobin as oxygen-dependent glutathione buffer" DOI 10.5281/zenodo.5817228 </p>
Data for A Locally Activatable Sensor for Robust Quantification of Organellar Glutathione
<p>Supporting data to paper A Locally Activatable Sensor for Robust Quantification of Organellar Glutathione,</p> <p>including NMR, MS, microscopy, etc</p>
Fig. 1. A in Agricultural Trichothecene Mycotoxin Contamination Affects The Life-History And Reduced Glutathione Content Of Folsomia Candida Willem (Collembola)
Fig. 1. A relative growth of Folsomia candida on the relation of the contaminated food; significant difference in mean B. Total reproduction of Folsomia candida in the contaminated
Figure 4. Specific glutathione S-transferase activity changes toward 1 in Confirmation and differential metabolism associated with quinclorac resistance in smooth crabgrass (Digitorio ischoemum)
Figure 4. Specific glutathione S-transferase activity changes toward 1-chloro-2,4- dinitrobenzene in Digitorio ischoemum tissues after (A) 0.84 kg quinclorac ha−1 or (B) 7.56 kg quinclorac ha−1. Data were expressed as a percentage change of the nontreated. Values are presented as mean ± SE. Error bars indicate the standard error of the mean. R, resistant; S, susceptible.
Fig. 2. Glutathione-S in The essential oil from Lippia alba induces biochemical stress in the silver catfish (Rhamdia quelen) after transportation
Fig. 2. Glutathione-S-transferase (GST) activity (A), glutathione peroxidase (GPx) activity (B), non-protein thiol group (NPSH) content (C) and ascorbic acid (D) content in the liver of silver catfish (Rhamdia quelen) transported in plastic bags containing water treated with the essential oil from Lippia alba. The values are expressed as the means ± SEM. Different letters indicate levels of significance between the treatments (P<0.05).
USP5 zinc-finger ubiquitin binding domain with L-cysteine(residue195)-glutathione disulfide structure solution
<p>USP5 zinc-finger ubiquitin binding domain with L-cysteine(residue195)-glutathione disulfide structure solution to 1.6 Å resolution</p>
FIGURE 4 in A typical enzyme activity for glutathione conjugation indicates exposure of pacu to pollutants
FIGURE 4 |GST specific activities in kidney cytosol from Piaractus mesopotamicus injected with benzo[a]pyrene (15 mg kg-1). Assays were carried out with 1-chloro-2,4-dinitrobenzene (CDNB), ethacrynic acid (ETHA) or 2-dichloro-4-nitrobenzene (DCNB) 7 and 14 days after the injection. Bars represent the means ± S.E.M. of determinations from nine fish injected with corn oil (clear) or benzo[a]pyrene (dark grey). Significant different from controls are indicated as *(P <0.05) and ***(P <0.001).
FIGURE 3 in A typical enzyme activity for glutathione conjugation indicates exposure of pacu to pollutants
FIGURE 3 |GST specific activities in liver cytosol from Piaractus mesopotamicus injected with benzo[a]pyrene (15 mg kg-1). Assays were carried out with 1-chloro-2,4-dinitrobenzene (CDNB), ethacrynic acid (ETHA) or 2-dichloro-4-nitrobenzene (DCNB) 7 and 14 days after the injection. Bars represent the means ± S.E.M. of assays from nine fish injected with corn oil (clear) or benzo[a]pyrene (dark grey). Significant different from controls are indicated as ***(P <0.001).
FIGURE 2 in A typical enzyme activity for glutathione conjugation indicates exposure of pacu to pollutants
FIGURE 2 |GST specific activities in kidney cytosol from Piaractus mesopotamicus injected with methyl parathion (8 mg kg-1). Assays were carried out with 1-chloro-2,4-dinitrobenzene (CDNB), ethacrynic acid (ETHA) or 2-dichloro-4-nitrobenzene (DCNB) at 24, 48 and 96 hours after the injection. Bars represent the means ± S.E.M. of assays from five fish injected with corn oil (clear) or methyl parathion (dark grey).
FIGURE 1 in A typical enzyme activity for glutathione conjugation indicates exposure of pacu to pollutants
FIGURE 1 |GST specific activities in liver cytosol from Piaractus mesopotamicus injected with methyl parathion (8 mg kg-1). Assays were carried out with 1-chloro-2,4-dinitrobenzene (CDNB), ethacrynic acid (ETHA) or 2- dichloro-4-nitrobenzene (DCNB) at 24, 48 and 96 hours after the injection. Bars represent the means ± S.E.M. of assays from five fish injected with corn oil (clear) or methyl parathion (dark grey). Significant differences from controls are indicated as **(P <0.01).
Effects of yeast strain and juice nitrogen status on glutathione utilisation during fermentation of model media
<p><strong>Background and Aims</strong></p> <p>An OIV resolution provides guidelines on using glutathione as a prefermentation additive when the amount of yeast assimilable nitrogen (YAN) of a juice or must is adequate, to avoid the metabolism of glutathione by the yeast. The effect of YAN concentration on glutathione metabolism by yeast had not been determined. This study explored whether nitrogen management could be used to control glutathione consumption during fermentation.</p> <p><strong>Methods and Results</strong></p> <p>An HPLC-UV method was developed to quantify reduced L-glutathione (GSH) and oxidised glutathione (GSSG) and used to monitor yeast GSH metabolism during alcoholic fermentation with two yeast strains (AWRI 1688 and AWRI 2861). The addition of GSH had no impact on the fermentation rate of the chemically defined medium, even in a limited YAN environment; however, a decrease in glutathione concentration occurred regardless of YAN concentration. The effect of GSH on volatile sulfur compound formation was yeast strain-dependent.</p> <p><strong>Conclusions</strong></p> <p>Increasing the YAN status of a chemically defined medium led to a decrease in GSH consumption during fermentation, but the loss of GSH could not be prevented entirely, even with a low initial GSH concentration and high initial YAN.</p> <p><strong>Significance of the Study</strong></p> <p>In the presence of higher concentrations of GSH during fermentation, there is a risk of forming undesirable fermentative sulfur compounds that are not mitigated through nitrogen supplementation. Thus, it seems unlikely that an argument could be made for the inclusion of GSH in relevant food standards codes as a wine additive especially if a lack of GSH metabolism was a criterion.</p>
Cystine/glutamate antiporter system Xc- deficiency impairs macrophage glutathione metabolism and cytokine production.
<p>Raw Data for Publication "Cystine/glutamate antiporter system Xc- deficiency impairs macrophage glutathione metabolism and cytokine production."</p>
Effects of yeast strain and juice nitrogen status on glutathione utilisation during fermentation of model media
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Glutathione data of Eurasian siskins either infected with avian malaria or not
Open the record for dataset details and reuse information.
Glutathione and neodiosmin feedback sustain plant immunity
<p>Plants have evolved a two-layer immune system comprising pattern-triggered immunity (PTI) and effector-triggered immunity (ETI) that is activated in response to pathogen invasion. Microbial patterns and pathogen effectors can be recognized by surface-localized pattern-recognition receptors (PRRs) and intracellularly localized nucleotide-binding leucine-rich repeat receptors (NLRs) to trigger PTI and ETI responses, respectively. At present, the metabolites activated by PTI and ETI and their roles and signalling pathways in plant immunity are not well understood. In this study, metabolomic analysis showed that ETI and PTI induced various flavonoids and amino acids and their derivatives in plants. Interestingly, both glutathione and neodiosmin content were specifically up-regulated by ETI and PTI, respectively, which significantly enhanced plant immunity. Further studies showed that glutathione and neodiosmin failed to induce a plant immune response in which PRRs/co-receptors were mutated. In addition, glutathione-reduced mutant gsh1 analysis showed that GSH1 is also required for PTI and ETI. Finally, we propose a model in which glutathione and neodiosmin are considered signature metabolites induced in the process of ETI and PTI activation in plants and further continuous enhancement of plant immunity in which PRRs/co-receptors are needed. This model is beneficial for an in-depth understanding of the closed-loop mode of the positive feedback regulation of PTI and ETI signals at the metabolic level.</p>
The catalytic role of glutathione transferases in heterologous anthocyanin biosynthesis
<p>Electronic energies, entropies, enthalpies, Gibbs free energies, and lowest frequencies of the QM-calculated structures (<em>QM_Energies.xlsx</em>).</p> <p>Gaussian 16 input and output files, and optimized geometries in MOL2 format, for all QM-calculated structures <em>(QM_calculations.zip</em>).</p> <p>Input coordinates, topology file (in Amber and PDB formats) and output geometries (in PDB format) for the Molecular Dynamics equilibration of the GST-GSH-flav-3-on-4-ol (<strong>7</strong>) ternary complex (<em>MD_equilibration.zip</em>).</p> <p>Optimized geometries for the PtGSTF8-catalyzed deprotonation-protonation reaction: flavan-3-on-4-ol (<strong>7</strong>), transition state for deprotonation (<strong>7-TS</strong>), deprotonation product (<strong>8-enolate</strong>) and cyanidin (<strong>8-B4</strong>) bound to the wildtype enzyme and the C13S variant (<em>QMMM_optimized_structures.zip</em>).</p> <p> </p> <p> </p>
Glutathione Metabolism in Adolescents With Type 1 Diabetes - Study B
ClinicalTrials.gov study NCT00858273. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Enrichment of Glutathione Using Gamma-glutamylcysteine Supplementation in Parkinson's Disease Patients.
ClinicalTrials.gov study NCT07064005. IPD Sharing: YES. Countries: 1. Publications: 3.
Comparison of Effectiveness of Tranexamic Acid Mesotherapy Versus Glutathione Mesotherapy in Post Burn Facial Hyperpigmentation
ClinicalTrials.gov study NCT07263841. IPD Sharing: NO. Countries: 1. Publications: 1.
The Role of Oral Glutathione on Growth Parameters in Children With Cystic Fibrosis
ClinicalTrials.gov study NCT03020719. IPD Sharing: NO. Countries: 1. Publications: 1.
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