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125 results for “glycogen”
Design, Synthesis and Biological Evaluation of 7-Chloro-9H-pyrimido[4,5-b]indole-based Glycogen synthase kinase-3β inhibitors
<p>The dataset related to the publication:</p> <p>Andreev et al. Design, Synthesis and Biological Evaluation of 7 Chloro-9H-pyrimido[4,5-b]indole-based Glycogen synthase kinase-3β inhibitors.<br> <br> The files include:</p> <p>1) Movies of the MD simulations of compounds 14b (<strong>Cmpd14b.mpg</strong>) and 24 (<strong>Cmpd24.mpg</strong>).</p> <p>2) Raw trajectory files of the Desmond MD simulations of the compounds 14b (<strong>14b.zip</strong>), 24 (<strong>24.zip</strong>) and 24 (3a<em>R</em>, 7a<em>S</em>) (<strong>24_3aR_7aS.zip</strong>) (contains out.cms and the full trj files).</p> <p>3) Output conformations of the QM Tautomer & Conformation Predictor of Maestro (Schrödinger, LLC, New York, NY, 2019) of the compounds<br> 14b (<strong>Cmpd14b_QMconftauto_output.mae</strong>; <strong>Cmpd14b_QMconftauto_output.sdf</strong>), <br> 24 (<strong>Cmpd24_QMconftauto_output.mae</strong>; <strong>Cmpd24_QMconftauto_output.sdf</strong>) and <br> 24 (3a<em>R</em>, 7a<em>S</em>) (<strong>Cmpd24_3aR_7aS_QMconftauto_output.mae</strong>; <strong>Cmpd24_3aR_7aS_QMconftauto_output.sdf</strong>)</p> <p>4) Jaguar pKa calculation (conformations) output-files for compounds 14b, 14c, 14d, 14e, 14f, 14g, 14h, 14i, 14j, 14k, 14l, 14m, 14n <strong>pKa.zip</strong> (contains conformation in .mae file and Final weighted pKa value in .out file).</p>
Fig 3 in Sodium fluoride induce alterations in glycogen metabolism in freshwater catfish, Clarias batrachus (Linn.)
Fig 3: Effect of NaF on testis tissue glycogen content
Fig 2 in Sodium fluoride induce alterations in glycogen metabolism in freshwater catfish, Clarias batrachus (Linn.)
Fig 2: Effect of NaF on liver tissue glycogen content
Table 1 in Sodium fluoride induce alterations in glycogen metabolism in freshwater catfish, Clarias batrachus (Linn.)
<p><b>Table 1:</b> Level of glycogen content (mg/g wet tissues) in muscle, liver and testis tissues of <i>C. batrachus</i> after exposure to NaF.</p><table><tbody><tr><th><b>Parameters</b></th><th><b>Exposure Time (Days)</b></th><th><b>Group I (Control)</b></th><th><b>Experimental setup Group II (35 mg F/L)</b></th><th><b>Group III (70mg F/L)</b></th></tr></tbody><tbody><tr><th>Muscle glycogen</th><td>60</td><td>0.87 ± 0.16</td><td>0.72 ± 0.13</td><td>1.72 ±0.14*</td></tr><tr><th>(mg/g wet tissue)</th><td>90</td><td>0.85 ± 0.12</td><td>0.52 ±0.10</td><td>1.85±0.10*</td></tr><tr><th>Liver glycogen</th><td>60</td><td>20.82 ± 1.01</td><td>18.24 ± 0.68</td><td>25.92 ± 0.93*</td></tr><tr><th>(mg/g wet tissue)</th><td>90</td><td>20.95 ±1.02</td><td>18.12 ± 1.20</td><td>28.02 ±1.10*</td></tr><tr><th>Testis glycogen</th><td>60</td><td>9.12 ± 0.85</td><td>6.02 ± 0.83*</td><td>5.60± 0.62*</td></tr><tr><th>(mg/g wet tissue)</th><td>90</td><td>9.25 ± 0.70</td><td>4.85 ± 0.52*</td><td>3.02± 0.54**</td></tr></tbody></table><p>(Values are mean ± SE, n= 6, Compared with control * <i>P<</i>0.01, ** <i>P<</i>0.001)</p>
A Study to Investigate the Effect of MEDI0382 on Hepatic Glycogen Metabolism in Overweight and Obese Subjects With Type 2 Diabetes Mellitus.
ClinicalTrials.gov study NCT03555994. IPD Sharing: YES. Countries: 3. Publications: 1.
Safety and Dose-Finding Study of DTX401 (AAV8G6PC) in Adults With Glycogen Storage Disease Type Ia (GSDIa)
ClinicalTrials.gov study NCT03517085. IPD Sharing: Not stated. Countries: 4. Publications: 3.
Data from: A splice mutation in the PHKG1 gene causes high glycogen content and low meat quality in pig skeletal muscle
Glycolytic potential (GP) in skeletal muscle is economically important in the pig industry because of its effect on pork processing yield. We have previously mapped a major quantitative trait loci (QTL) for GP on chromosome 3 in a White Duroc × Erhualian F2 intercross. We herein performed a systems genetic analysis to identify the causal variant underlying the phenotype QTL (pQTL). We first conducted genome-wide association analyses in the F2 intercross and an F19 Sutai pig population. The QTL was then refined to an 180-kb interval based on the 2-LOD drop method. We then performed expression QTL (eQTL) mapping using muscle transcriptome data from 497 F2 animals. Within the QTL interval, only one gene (PHKG1) has a cis-eQTL that was colocolizated with pQTL peaked at the same SNP. The PHKG1 gene encodes a catalytic subunit of the phosphorylase kinase (PhK), which functions in the cascade activation of glycogen breakdown. Deep sequencing of PHKG1 revealed a point mutation (C>A) in a splice acceptor site of intron 9, resulting in a 32-bp deletion in the open reading frame and generating a premature stop codon. The aberrant transcript induces nonsense-mediated decay, leading to lower protein level and weaker enzymatic activity in affected animals. The mutation causes an increase of 43% in GP and a decrease of>20% in water-holding capacity of pork. These effects were consistent across the F2 and Sutai populations, as well as Duroc × (Landrace × Yorkshire) hybrid pigs. The unfavorable allele exists predominantly in Duroc-derived pigs. The findings provide new insights into understanding risk factors affecting glucose metabolism, and would greatly contribute to the genetic improvement of meat quality in Duroc related pigs.
Study to Evaluate the Effect of ISIS GCGRRx on Hepatic Lipid and Glycogen Content in Type 2 Diabetes
ClinicalTrials.gov study NCT02824003. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study of Long-Term Safety and Efficacy on Gene Therapy in Glycogen Storage Disease Type Ia
ClinicalTrials.gov study NCT03970278. IPD Sharing: NO. Countries: 4. Publications: 0.
Study of Glycogen Storage Disease Expression in Carriers
ClinicalTrials.gov study NCT02057731. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Improving Glycogen Liver Content Will Improve Post-operative Liver Function in Patients Undergoing Major Liver Resections
ClinicalTrials.gov study NCT00774098. IPD Sharing: Not stated. Countries: 1. Publications: 3.
The Use of Uncooked Sweet Manioc Starch to Treat Hepatic Glycogen Storage Diseases
ClinicalTrials.gov study NCT03871673. IPD Sharing: NO. Countries: 1. Publications: 1.
The Impact of Sucrose Ingestion During Exercise on Liver and Muscle Glycogen Concentration.
ClinicalTrials.gov study NCT02110836. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effect of Triheptanoin in Adults With McArdle Disease (Glycogen Storage Disease Type V)
ClinicalTrials.gov study NCT02432768. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Anaplerotic Therapy Using Triheptanoin for Patients With Glycogen Storage Disease Type I
ClinicalTrials.gov study NCT03665636. IPD Sharing: NO. Countries: 1. Publications: 8.
Effect of Glycogen Replenishment on Time Trial Performance Following a Glycogen Lowering Exercise
ClinicalTrials.gov study NCT03682861. IPD Sharing: NO. Countries: 1. Publications: 2.
Endogenous Glucose Production in Patients With Glycogen Storage Disease Type Ia
ClinicalTrials.gov study NCT04311307. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of mRNA-3745 in Adult and Pediatric Participants With Glycogen Storage Disease Type 1a (GSD1a)
ClinicalTrials.gov study NCT05095727. IPD Sharing: Not stated. Countries: 6. Publications: 1.
Glycogen and Appetite
ClinicalTrials.gov study NCT05417659. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Glycogen Metabolism in Children
ClinicalTrials.gov study NCT04278209. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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