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5 results for “gold nanoclusters”
Hydrolase and Peroxidase Activity of Gold Nanocluster Composites with Lysozyme and Cross-Linked Lysozyme Crystals
<div> <div> <p>Lysozyme (Lyz) and cross-linked Lyz crystals (CLLC) are among the proteins and templates used in the bio-inspired synthesis of subnanometer-sized gold nanoclusters (AuNCs) utilized in various biological applications as biosensors or bioimaging agents and recyclable catalyst, respectively. While previous studies have explored the formation and stabilization of AuNCs in the presence of Lyz, little is known about the enzymatic activity of Lyz after stabilization of AuNCs with the protein (AuNC@Lyz) and in CLLC (AuNC@CLLC). In this study, we conducted a comprehensive analysis of AuNC@Lyz, including hydrodynamic characteristics using multiwavelength fluorescence analytical ultracentrifugation and enzymatic activity assays. AuNC@Lyz exhibited bactericidal performance as efficiently as Lyz at pH 4.0, with enzymatic activity assays indicating more efficient hydrolytic activity of AuNC@Lyz compared to Lyz under the same conditions. Additionally, AuNC@Lyz showed peroxidase-like performance due to the catalytically active surface of AuNCs in the presence of H<sub>2</sub>O<sub>2</sub> and a chromogenic substrate. The multifunctional catalytic capabilities of AuNC@Lyz, including lytic activity and mimic peroxidase function, were highlighted. Additionally, we conducted fluorescent-based hydrolytic activity assays of CLLC, revealing that morphological variations of CLLC influence the catalytic performance of the enzyme crystals depending on the size of solvent channels and Lyz conformation within the CLLC. Furthermore, the bio-inspired synthesis of AuNCs in CLLC resulted in size distributions of AuNCs correlated with pore sizes. As a consequence of the occluded solvent channels and limited breathing of CLLC, AuNC@CLLC displayed a diminishing hydrolytic performance.</p> </div> </div>
Research data supporting "Renal clearable catalytic gold nanoclusters for in vivo disease monitoring"
<p>Raw research data suppoorting the publication:</p> <p>Loynachan C., et al., 2019, Nature Nanotechnology, DOI: https://doi.org/10.1038/s41565-019-0527-6</p>
Research data supporting "Surface dynamics and ligand-core interactions of quantum size photoluminescent gold nanoclusters"
<p>Experimental research raw data supporting the publication by Lin, Y. et al, 2018, Surface dynamics and ligand-core interactions of quantum sized photoluminescent gold nanoclusters, Journal of the American Chemical Society. DOI: 10.1021/jacs.8b04436</p> <p>Molecular simulation data is available upon reasonable request from irene.yarovsky@rmit.edu.au.</p>
Bonding of gold nanoclusters on graphene with and without point defects
<p>Theoretical data set for the Nanomaterials paper "Bonding of gold nanoclusters on graphene with and without point defects".</p> <p>Data structure and formats are described in the README.docx file.</p>
RNA-Seq-guided triple-combination nano-system of gold nanocluster, quercetin, and docetaxel for ultimate synergistic photothermal-chemotherapy against MDR tumor
GEO Series GSE224908. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.