Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
1,294
datasets available to search
ShareScore release 0.9.0
Dataset results
1,294 results for “hemodynamics”
Functional Near-Infrared Spectroscopy Reveals Delayed Hemodynamic Changes in the Primary Motor Cortex During Fine Motor Tasks and Decreased Interhemispheric Connectivity in Parkinson's Disease Patients
<p>This dataset contains functional near-infrared spectroscopy (fNIRS) data from 20 patients with Parkinson’s disease and 20 age- and sex-matched healthy subjects without movement disorders. There are 3 folders, each corresponding to a different task: a 10-second finger-tapping task, a 2-minute walking task, and a 6-minute resting-state. When using this dataset, please cite our work:</p> <div> <div>Guevara, E., Rivas-Ruvalcaba, F. J., Kolosovas-Machuca, E. S., Ramírez-Elías, M., Zapata, R. D. de L., Ramirez-GarciaLuna, J. L., & Rodríguez-Leyva, I. (2024). Parkinson’s disease patients show delayed hemodynamic changes in primary motor cortex in fine motor tasks and decreased resting-state interhemispheric functional connectivity: A functional near-infrared spectroscopy study. <em>Neurophotonics</em>, <em>11</em>(2), 025004. <a href="https://doi.org/10.1117/1.NPh.11.2.025004">https://doi.org/10.1117/1.NPh.11.2.025004</a></div> <div> <div> <div>Guevara, E., Solana-Lavalle, G., & Rosas-Romero, R. (2024). Integrating fNIRS and machine learning: Shedding light on Parkinson’s disease detection. <em>EXCLI Journal</em>, <em>23</em>, 763–771. <a href="https://doi.org/10.17179/excli2024-7151">https://doi.org/10.17179/excli2024-7151</a></div> <div> <div> <div> <div> <div>Guevara, E., Kolosovas-Machuca, E. S., & Rodríguez-Leyva, I. (2024). Exploring motor cortex functional connectivity in Parkinson’s disease using fNIRS. <em>Brain Organoid and Systems Neuroscience Journal</em>, <em>2</em>, 23–30. <a href="https://doi.org/10.1016/j.bosn.2024.04.001">https://doi.org/10.1016/j.bosn.2024.04.001</a></div> </div> </div> </div> </div> </div> </div> </div>
Data and codes for 'A Bayesian Approach to Blood Rheological Uncertainties in Aortic Hemodynamics'
<p>This submission is supplementary material in the form of data and codes used in and for the manuscript 'A Bayesian Approach to Blood Rheological Uncertainties in Aortic Hemodynamics' submitted to the International Journal of Numerical Methods in Biomedical Engineering (currently under review).</p>
Arterial hemodynamics: a database of virtual subjects
<p>We present a novel methodology to assess theoretically physiological computed indices and algorithms based on pulse wave analysis in the large arteries of the cardiovascular system. </p> <p>We have created a database of virtual healthy adult subjects using a validated one-dimensional numerical model of the arterial hemodynamics, which cardiac and arterial parameters are varied within physiological healthy ranges. The generated set of simulations encloses more than 3300 cases which could be encountered in a clinical study. For each simulation, hemodynamic signals (e.g. pressure, flow and distension waveforms) are available at all arterial locations, and allow the computation of indices of interest.</p> <p>The database has been efficiently used to assess the accuracy of the foot-to-foot pulse wave velocities for estimation of aortic stiffness [1] and other physiological indices. It is an efficient way to validate an algorithm based on pressure and flow signals without suffering from experimental error. Finally, the database can be used to understand the theoretical mechanisms of wave propagation: since all arterial parameters are known, one can easily post-process the pressure and flow waveforms. </p> <p>[1] M. Willemet, P. Chowienczyk and J. Alastruey.<strong> </strong>A database of virtual healthy subjects to assess the accuracy of foot-to-foot pulse wave velocities for estimation of aortic stiffness. <em>American Journal of Physiology - Heart and Circulatory Physiology, </em>309(4):H663-H675, 2015</p> <p> </p> <p>Data is saved in Matlab formatted files, with results sorted by arterial location, and physiology of the results (each file is about 300 MB). In addition, the Fictive_database.mat file stores a description of the arterial network geometry, and values of computed physiological indices (e.g. Cardiac Output, PWV, Pulse Pressure). The structure of the database is explained in details in the manual document.</p>
Sensitivity analysis of a mathematical model simulating the post-hepatectomy hemodynamics response
<p>Recently a lumped-parameter model of the cardiovascular system was proposed to simulate the hemodynamics response to partial hepatectomy and evaluate the risk of portal hypertension (PHT) due to this surgery. Model parameters are tuned based on each patient data. This work focuses on a global sensitivity analysis (SA) study of such model to better understand the main drivers of the clinical outputs of interest. The analysis suggests which parameters should be considered patient-specific and which can be assumed constant without losing in accuracy in the predictions. While performing the SA, model outputs need to be constrained to physiological ranges. An innovative approach exploits the features of the polynomial chaos expansion method to reduce the overall computational cost. The computed results give new insights on how to improve the calibration of some model parameters. Moreover the final parameter distributions enable the creation of a virtual population available for future works. Although this work is focused on partial hepatectomy, the pipeline can be applied to other cardiovascular hemodynamics models to gain insights for patient-specific parameterization and to define a physiologically relevant virtual population.</p>
Data from: Relating pupil diameter and blinking to cortical activity and hemodynamics across arousal states
<p>Arousal state affects neural activity and vascular dynamics in the cortex, with sleep associated with large changes in the local field potential (LFP) and increases in cortical blood flow. We investigated the relationship between pupil diameter and blink rate with neural activity and blood volume in the somatosensory cortex in male and female unanesthetized, head-fixed mice. We monitored these variables while the mice were awake, during periods of rapid eye movement (REM), and during non-rapid eye movement (NREM) sleep. Pupil diameter was smaller during sleep than in the awake state. Changes in pupil diameter were coherent with both gamma-band power and blood volume in the somatosensory cortex, but the strength and sign of this relationship varied with arousal state. We observed a strong negative correlation between pupil diameter and both gamma-band power and blood volume during periods of awake rest and NREM sleep, though the correlations between pupil diameter and these signals became positive during periods of alertness, active whisking, and REM. Blinking was associated with increases in arousal and decreases in blood volume when the mouse was asleep. Bilateral coherence in gamma-band power and in blood volume dropped following awake blinking, indicating a 'reset' of neural and vascular activity. Using only eye metrics (pupil diameter and eye motion), we could determine the mouse's arousal state ('Awake', 'NREM', 'REM') with greater than 90% accuracy with a 5-second resolution. There is a strong relationship between pupil diameter and hemodynamics signals in mice, reflecting the pronounced effects of arousal on cerebrovascular dynamics.</p>
Vertebral Artery and Cerebral Hemodynamics After Various Head Positions & Manipulation in Patients With Neck Pain
ClinicalTrials.gov study NCT02667821. IPD Sharing: YES. Countries: 1. Publications: 13.
Data from: Relating pupil diameter and blinking to cortical activity and hemodynamics across arousal states
Open the record for dataset details and reuse information.
Hemodynamic responses link individual differences in informational masking to the vicinity of superior temporal gyrus
Open the record for dataset details and reuse information.
Raw fMRI data from 12 rats used in the manuscript "Mapping of hemodynamic responses to the sensorymotor stimulation in a rodent model: a BOLD fMRI study" submitted to PlosOne for publication
<p>Raw data are from twelve male adult Wistar rats (Charles River Laboratories, Paris-France) weighing 300 ± 20g.</p> <p>Rats were initially anesthetized (induction) with 3% isoflurane and were maintained under 0,7-0.8% (sedation along with a muscle relaxation) during fMRI session. </p> <p>Each rat was submitted to two fMRI sessions: one with TE of 30 ms and and other with TE of 40 ms.</p> <p>For fMRI acquisition, electrodes were inserted subcutaneously in the palmar surface of the right hindpaw of each rat and electrical stimulation (current pulses with a 1.7 mA amplitude, 10 ms duration and 8 Hz frequency) was applied in a block-design starting with a resting period of 25s as a baseline followed by 25s stimulation, repeated 8 times.</p> <p>Ten 1-mm thick contiguous axial slices, from -6.36 mm to +2.64 mm to Bregma, were acquired with a two-shot gradient echo planar imaging (GE EPI) pulse sequence (2.56 cm2 FOV; 64x64 matrix size; a TR of 1000 ms; a flip angle of 50°) resulting in the pixel size of 0.4 mm.</p> <p>All imaging experiments were performed on a 4.7T Bruker (Biospec 47/40, Bruker, GmbH, Ettlingen,Germany) with a horizontal bore magnet equipped with a 12 cm gradient coil (Bruker BGA12, 400 mT/m) and interfaced to AVANCE III console. Two actively decoupled RF coils were used: a 7.2-cm diameter volume coil for transmission and a 2-cm diameter surface coil (Rapid Biomedical, Rimpar, Germany) positioned on the top of the animal's head for reception.</p>
Four-dimensional computational ultrasound imaging of brain hemodynamics
<p><span>Four-dimensional ultrasound imaging of complex biological systems such as the brain is technically challenging because of the spatiotemporal sampling requirements. We present computational ultrasound imaging (cUSi), an imaging method that uses complex ultrasound fields that can be generated with simple hardware and a physical wave prediction model to alleviate the sampling constraints. cUSi allows for high-resolution four-dimensional imaging of brain haemodynamics in awake and anesthetized mice.</span></p>
Validation of transpulmonary thermodilution variables in hemodynamically stable patients with heart diseases - Individual patient data
<p>This dataset contains individual subject data for hemodynamic measurements assessed in the present study.</p>
Data from: The global effect of aortic coarctation on carotid and renal pulsatile hemodynamics
<p>Coarctation of the aorta (CoA) is a congenital disease characterized by the narrowing of the aorta, typically the descending portion after the left subclavian artery. If left untreated, by the time individuals reach 50 years of age, the mortality rate can reach 90%. Previous studies have highlighted the adverse effects of CoA on local hemodynamics. However, no study has investigated the global hemodynamic effects of CoA in end-organ (brain and kidney) damage. Clinical studies have shown that coarctation acts as a reflection site, potentially damaging the hemodynamics of the brain and kidneys. Our goal in this study is to investigate the underlying mechanisms of these altered wave dynamics and their impacts on the pulsatile hemodynamics of end-organs. In this study, we use a physiologically accurate in-vitro experimental setup that simulates the hemodynamics of systemic circulation. Experiments are conducted across various cardiac outputs, heart rates, and coarctation degrees using aortas across a wide range of aortic stiffnesses. Our principal finding is that CoA increases cerebral blood flow and harmful pulsatile energy transmission to the brain. Conversely, both renal blood flow and pulsatile energy transmission to the kidneys are reduced in CoA at every level of aortic stiffness.</p>
Supplementary material to: Angioarchitecture and hemodynamics of microvascular arterio-venous malformations
<p>Supplementary material (code and raw data) to the manuscript "Angioarchitecture and hemodynamics of microvascular arterio-venous malformations" by Frey et al., under consideration for publication in PLOS One</p>
Factor XII deletion mitigates cerebral microbleed load but not hemodynamic dysfunction in the arcAβ mice
<p>Cerebrovascular dysfunction and a prothrombotic state have been found in patients with Alzheimer’s disease (AD). The factor XII (FXII)-driven activated contact system has been implicated in the vascular pathology and inflammation in AD patients and AD mouse models. Here we investigated the effect of genetic deletion of <em>FXII</em> on AD-related vascular dysfunction using magnetic resonance imaging (MRI). AD mouse line ArcAβ, arcAβ/<em>FXII-/-</em>, <em>FXII-/-</em> and non-transgenic littermates of 17 months of age (n = 40) were assessed for 1) cerebral microbleeds (CMB) load using susceptibility weighted imaging (SWI) MRI, 2) cerebral blood flow (CBF) using arterial spin labeling, and 3) vascular reactivity by estimating changes in cerebral blood volume (∆CBV) during hypercapnic stimulus using acetazolamide.</p>
Comparative Study of Intravenous Esmolol & Magnesium Sulphate in Attenuating Hemodynamic Response during Laryngoscopy & Endotracheal Intubation in Patients Undergoing Valvular Heart Surgery: a Randomised Clinical Trial
<p>The present study aimed to compare the effectiveness of esmolol & magnesium sulphate in attenuating the hemodynamic response<br> to endotracheal intubation and to note any signifi cant side effects caused by these drugs.<br> Background: Induction with endotracheal intubation in patients undergoing valvular heart replacement pose lot of hemodynamic<br> variations. Obtunding hemodynamic response which can be deleterious in such patients pose a challenge to the cardiac anaesthetist. We<br> hypothesized that using esmolol as compared to magnesium sulphate will attenuate the hemodynamic response during laryngoscopy &<br> endotracheal intubation in patients undergoing valvular heart replacement.<br> Methods: This was a double blind, randomised, single centre, interventional, prospective study. In this study 96 patients were divided<br> into two groups with 48 patients each (n = 48) by sealed enveloped method of randomisation. Group E received esmolol 1.5 mg/ kg i.v<br> and Group M received magnesium sulphate 50 mg/ kg i.v each diluted in normal saline to make up a volume of 50 ml & given via infusion<br> slowly over 5 minutes by a burette set. Hemodynamic parameters like Heart Rate (HR), Mean Arterial Pressure (MAP), Systolic Blood<br> Pressure (SBP), Diastolic Blood Pressure (DBP) at baseline, 5 minutes after premedication, just before intubation 3, 5, 10 & 15 minutes<br> post intubation were recorded. The last observation at the end of 15 minutes post intubation was considered as the end of study.<br> Results: All the enrolled patients were analyzed. The esmolol group showed a decrease in the H.R from baseline (86.13 ± 15.87)<br> as compared to magnesium sulphate (98.51 ± 16.81 with a 95% CI, 4.62-4.69, p value < 0.001) 5 minute after premedication. There was<br> statistically signifi cant difference in H.R between both groups 5 minutes after drug administration.<br> Conclusion: Administration of esmolol before intubation in valvular heart patients undergoing valve replacement surgery controls the<br> hemodynamic response much better as compared to magnesium sulphate.</p>
Raw Data for the article: Right vs left portal branch puncture in TIPS creation with controlled expansion covered stent: comparison of hemodynamic and clinical outcomes
<p><strong>Purpose: </strong>To retrospectively compare outcomes of TIPS performed by puncturing left portal vein (LPV) vs right portal vein (RPV) to access the portal system.</p> <p><strong>Materials and methods: </strong>One hundred ninety-three consecutive patients underwent TIPS with controlled expansion covered stent by using the LPV (37 patients) or the RPV (156 patients). Patients were followed until the last clinical evaluation, liver transplantation, or death.</p> <p><strong>Results: </strong>Demographics and clinical characteristics of the two groups were comparable. The median follow-up was 9.6 months (range 0.1-50.6). Portosystemic pressure gradient (PSG) before TIPS 15.7 mmHg ± 4.7 in RPV group (RPVG) vs 15.4 mmHg ± 4.5 in LPV group (LPVG) (p = 0.725). After TIPS, PSG 6.3 mmHg ± 2.8 in RPVG vs 6.2 mmHg ± 2.2 (p = 0.839). In LPVG, the stent was dilated to 8-mm in 95% of patients vs 77% of RPVG (p = 0.015). Two (5.4%) and 22 (14%) patients underwent TIPS revision in LPVG and RPVG (p = 0.15). The incidence of overt HE was 13% in LPVG and 24% in RPVG (p = 0.177). Rebleeding occurred in 3 of 49 patients (6%) with variceal bleeding as an indication: 2/41 patients (4.9%) in RPVG vs 1/8 patients (12.5%) in LPVG (p = 0.417). Among 126 patients with refractory ascites 20 patients (15.9%) needed paracentesis 3 months after the procedure: 18/101 patients (17.8%) in RPVG vs 2/25 patients (8%) in LPVG (p = 0.231). Thirty-seven patients (19%) died: 32 (21%) in RPVG and 5 (14%) in LPVG (p = 0.337).</p> <p><strong>Conclusion: </strong>Compared with RPV puncture, in TIPS created through the LPV, the targeted PSG was reached with a smaller stent diameter. However, no significant difference in clinical outcomes was observed.</p>
Lumped parameter liver simulation to predict acute hemodynamic alterations following partial resections (simulation data)
<p>This repository contains MATLAB .mat files containing simulation data reported in the manuscript "Lumped parameter liver simulation to predict acute hemodynamic alterations following partial resections" by Jeffrey Tithof, Timothy L. Pruett, and Joseph Sushil Rao (University of Minnesota). See the README file for details of which data set corresponds to which figure.</p>
DATA SET: In vivo characterization of the optical and hemodynamic properties of the human sternocleidomastoid muscle through ultrasound-guided hybrid near-infrared spectroscopies.
<p>This repository contains the data sets of the article:</p><p>L. Cortese et al., "In vivo characterization of the optical and hemodynamic properties of the human sternocleidomastoid muscle through ultrasound-guided hybrid near-infrared spectroscopies."</p>
Randomized Trial of Early Hemodynamic Management of Patients Following Acute Spinal Cord Injury
ClinicalTrials.gov study NCT02878850. IPD Sharing: NO. Countries: 1. Publications: 2.
Closed-Loop Fluid Administration System Using Hemodynamic Monitors
ClinicalTrials.gov study NCT02020863. IPD Sharing: UNDECIDED. Countries: 1. Publications: 15.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.