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186 results for “hemostasis”
Hemostasis defects underlying the hemorrhagic syndrome caused by Mammarenaviruses in a cynomolgus macaque model
<p>Abstract: Viral hemorrhagic fevers (HF) are a group of acute febrile diseases with high mortality rates. While hemostatic dysfunction appears to be a major determinant of the severity of the disease, it is still unclear what pathogenic mechanisms lead to it. In clinical studies, arenaviruses such as Lassa, Machupo and Guanarito viruses caused HF that vary in symptoms and biological alterations.</p> <p>In this study we aimed to characterize the hemostatic dysfunction induced by arenaviral HF to determine its implication in the severity of the disease and to elucidate the origin of this syndrome.</p> <p>We found that lethal infection with Machupo, Guanarito and Lassa viruses is associated with cutaneo-mucosal, cerebral, digestive and pulmonary hemorrhages. The affected animals developed a severe alteration of the coagulation system, which was concomitant with acute hepatitis, minor deficit of hepatic factor synthesis, presence of a plasmatic inhibitor of coagulation and dysfunction of the fibrinolytic system. Despite signs of increased vascular permeability, endothelial cell infection was not a determinant factor of the hemorrhagic syndrome. There were also alterations of the primary hemostasis during lethal infection, with moderate to severe thrombocytopenia and platelet dysfunction. Finally, we show that lethal infection is accompanied by a reduced hematopoietic potential of the bone marrow. This study provides an unprecedented characterization of the hemostasis defects induced by several highly pathogenic Arenaviruses.</p> <p>Transcriptomics data presented in Figure 3 and in Supp Figure 2</p>
Safety and Efficacy of Topical Thrombin (Human) Grifols as an Adjunct to Hemostasis During Surgery
ClinicalTrials.gov study NCT02014402. IPD Sharing: Not stated. Countries: 1. Publications: 1.
BEACH Trial: Bovine Early Access, Compatibility and Hemostasis Trial
ClinicalTrials.gov study NCT04146012. IPD Sharing: NO. Countries: 1. Publications: 3.
Thulium Beam Coagulation Versus Suture Renorrhaphy for Hemostasis of Tumor Bed in Laparoscopic Partial Nephrectomy
ClinicalTrials.gov study NCT06322745. IPD Sharing: YES. Countries: 1. Publications: 0.
Immunogenicity and Safety Study of Topical Recombinant Thrombin in Surgical Hemostasis
ClinicalTrials.gov study NCT00491608. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Hemostasis in Kocher-Langenbeck Approaches for Acetabular Surgery Using a Topical Surgical Hemostat (Vitagel)
ClinicalTrials.gov study NCT01230931. IPD Sharing: Not stated. Countries: 1. Publications: 12.
Bone Wax Use for Hemostasis During Primary Unilateral Total Knee Arthroplasty
ClinicalTrials.gov study NCT04992052. IPD Sharing: NO. Countries: 1. Publications: 3.
Safety and Efficacy Study of Fibrin Sealant Grifols as an Adjunct to Hemostasis During Peripheral Vascular Surgery
ClinicalTrials.gov study NCT01662856. IPD Sharing: Not stated. Countries: 4. Publications: 1.
Comparison of A-PRF vs Bone Wax in Hemostasis, Pain Relief and Healing Following Exodontia
ClinicalTrials.gov study NCT05744726. IPD Sharing: NO. Countries: 1. Publications: 2.
Comparison of Percutaneous Closure to Manual Compression for Hemostasis
ClinicalTrials.gov study NCT04180540. IPD Sharing: NO. Countries: 1. Publications: 0.
A New Approach for Controlling Hemostasis During Canal Treatment
ClinicalTrials.gov study NCT03336853. IPD Sharing: NO. Countries: 1. Publications: 10.
U.S. Study of Fibrocaps in Surgical Hemostasis
ClinicalTrials.gov study NCT01256164. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety and Efficacy Study of Fibrin Sealant Grifols Evaluated as an Adjunct to Hemostasis
ClinicalTrials.gov study NCT00684047. IPD Sharing: Not stated. Countries: 3. Publications: 1.
sTErnAl heMostasiS Trial
ClinicalTrials.gov study NCT06511778. IPD Sharing: NO. Countries: 1. Publications: 2.
Seraseal for Endoscopic Hemostasis
ClinicalTrials.gov study NCT02349490. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Hypothermia and Hemostasis After Cardiac Arrest
ClinicalTrials.gov study NCT02258360. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Precise Delivery of Tranexamic Acid to Enhance Endoscopic Hemostasis for Peptic Ulcer Bleeding
ClinicalTrials.gov study NCT05248321. IPD Sharing: YES. Countries: 1. Publications: 12.
Effect of Patent Hemostatic Device (PHD) With Quantitative Pressure on Radial Artery Hemostasis After CAG/PCI
ClinicalTrials.gov study NCT05790603. IPD Sharing: NO. Countries: 1. Publications: 4.
The Impact of a Novel GnRH Antagonist With Add-back Therapy for Treatment of Uterine Fibroids and Endometriosis on Hemostasis Parameters
ClinicalTrials.gov study NCT07173127. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Hemostasis Alterations in Neurosurgical Patients
ClinicalTrials.gov study NCT02652897. IPD Sharing: NO. Countries: 1. Publications: 2.
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