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ShareScore release 0.9.0
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143 results for “hepatic steatosis”
Functional multispectral optoacoustic tomography imaging of hepatic steatosis development in mice_image analysis
<p>This dataset contains the HE staining/anti-CD31 staining/ICG fluorescence images and the image quantification data produced for publication "Functional multispectral optoacoustic tomography imaging of hepatic steatosis development in mice"</p>
Functional multispectral optoacoustic tomography imaging of hepatic steatosis development in mice
<p>This dataset contains primary data produced for pulication named 'Functional multispectral optoacoustic tomography imaging of hepatic steatosis development in mice'</p>
Astaxanthin from Haematococcus pluvialis prevents high-fat diet-induced hepatic steatosis and oxidative stress in mice by gut-liver axis modulating properties
<p><strong><span>Scope:</span></strong><span> Evidence is mounting that astaxanthin (ATX), a xanthophyll carotenoid, used as a nutritional supplement to prevent chronic metabolic diseases. The present study aims to identify the potential function of ATX supplementation in preventing steatohepatitis and hepatic oxidative stress in diet-induced obese mice.</span></p> <p><strong><span>Methods and Results:</span></strong><span> In this study, ATX as dose of 0.25%, 0.5% and 0.75% have orally administered to mice along with a high-fat diet (HFD) to investigate the role of ATX in regulating liver lipid metabolism and gut microbiota. The study showed that ATX dose-dependently reduces body weight, lipid droplet formation, hepatic triglycerides and ameliorated hepatic steatosis and oxidative stress. 0.75% ATX altered the levels of 34 lipid metabolites related to hepatic cholesterol and fatty acid metabolism which might be associated with downregulation of lipogenesis-related genes and upregulation of bile acid biosynthesis-related genes. The result also revealed that ATX alleviates HFD-induced gut microbiota dysbiosis by significantly inhibiting the growth of obesity-related <em>Parabacteroides</em> and <em>Desulfovibrio</em> while promoting the growth of <em>Allobaculum</em> and <em>Akkermansia</em>. </span></p> <p><span><strong>Conclusion:</strong> The study results suggested that dietary ATX may prevent the development of hepatic steatosis and oxidative stress with the risk of metabolic disease by gut-liver axis modulating properties.</span></p>
Data from: Hepatic steatosis induced by nicotine plus Coca-Cola™ is prevented by nicotinamide riboside (NR)
<p><strong>Introduction.</strong> Cigarettes containing nicotine (Nic) are a risk factor for the development of cardiovascular and metabolic diseases. We reported that Nic delivered via injections or e-cigarette vapor led to hepatic steatosis in mice fed with a high-fat diet. High-fructose corn syrup (HFCS) is the main sweetener in sugar-sweetened beverages (SSBs) in the US. Increased consumption of SSBs with HFCS is associated with increased risks of non-alcoholic fatty liver disease (NAFLD). Nicotinamide riboside (NR) increases mitochondrial nicotinamide adenine dinucleotide (NAD<sup>+</sup>) and protects mice against hepatic steatosis. This study evaluated if Nic plus Coca-Cola™ (Coke) with HFCS can cause hepatic steatosis and that can be protected by NR.</p> <p><strong>Methods.</strong> C57BL6 mice received twice daily intraperitoneal (IP) injections of Nic or saline and were given Coke (HFCS), or Coke with sugar, and NR supplementation for 10 weeks.</p> <p><strong>Results.</strong> Our results show that Nic+Coke caused increased caloric intake and induced hepatic steatosis, and the addition of NR prevented these changes. Western blot analysis showed lipogenesis markers were activated (increased cleavage of the sterol regulatory element-binding protein 1 [SREBP1c] and reduction of phospho-Acetyl-CoA Carboxylase [p-ACC]) in the Nic+Coke compared to the Sal+Water group. The hepatic detrimental effects of Nic+Coke were mediated by decreased NAD<sup>+</sup> signaling, increased oxidative stress, and mitochondrial damage. NR reduced oxidative stress and prevented mitochondrial damage by restoring protein levels of Sirtuin1 (Sirt1) and peroxisome proliferator-activated receptor coactivator 1-alpha (PGC1a) signaling.</p> <p><strong>Discussion.</strong> We conclude that Nic+Coke has an additive effect on producing hepatic steatosis, and NR is protective. This study suggests concern for the development of NAFLD in subjects who consume nicotine and drink SSBs with HFCS.</p>
Cholic Acid for Hepatic Steatosis in Lipodystrophy
ClinicalTrials.gov study NCT00457639. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Astaxanthin from Haematococcus pluvialis prevents high-fat diet-induced hepatic steatosis and oxidative stress in mice by gut-liver axis modulating properties
Open the record for dataset details and reuse information.
Data from: Hepatic steatosis induced by nicotine plus Coca-Cola™ is prevented by nicotinamide riboside (NR)
Open the record for dataset details and reuse information.
Aerobic Exercise Training in Patients With Chronic Hepatitis B and Hepatic Steatosis
ClinicalTrials.gov study NCT05265026. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Quantitative US for Hepatic Steatosis
ClinicalTrials.gov study NCT04180631. IPD Sharing: NO. Countries: 1. Publications: 1.
Febuxostat Versus Allopurinol on Hepatic Steatosis in MAFLD Patients
ClinicalTrials.gov study NCT05474560. IPD Sharing: NO. Countries: 1. Publications: 10.
Effect of Polyphenol Supplementation on Hepatic Steatosis and Vascular Compliance
ClinicalTrials.gov study NCT03994029. IPD Sharing: NO. Countries: 1. Publications: 1.
Effect of a GnRH Analog on Hepatic Steatosis
ClinicalTrials.gov study NCT06523530. IPD Sharing: YES. Countries: 1. Publications: 13.
Quantitative US for Evaluation of Hepatic Steatosis in NAFLD
ClinicalTrials.gov study NCT04462562. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Phase IV Study to Evaluate the Effects of Statin Monotherapy or Statin / Ezetimibe Combination Therapy on Hepatic Steatosis in Patients With Hyperlipidemia and Nonalcoholic Fatty Liver Disease
ClinicalTrials.gov study NCT03434613. IPD Sharing: NO. Countries: 1. Publications: 2.
The Effects of Coffee Main Constituents (Caffeine and Chlorogenic Acid) Supplementation on Inflammatory, Metabolic Factors, Hepatic Steatosis and Fibrosis in None- Alcoholic Fatty Liver Patients With
ClinicalTrials.gov study NCT02929901. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Hepatic Steatosis and Chronic Hepatitis B Virus
ClinicalTrials.gov study NCT05678582. IPD Sharing: NO. Countries: 1. Publications: 2.
Comparison of Acoustic Attenuation Parameter Using FibroTouch With Liver Biopsy for Diagnosis of Hepatic Steatosis
ClinicalTrials.gov study NCT02456766. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of Coffee on Hepatic Steatosis Induced by a High Fructose Diet
ClinicalTrials.gov study NCT00827450. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Relationship of Metabolic Abnormalities to Hepatic Steatosis in HIV
ClinicalTrials.gov study NCT00575757. IPD Sharing: Not stated. Countries: 1. Publications: 1.
An Observational Study Evaluating Patients With Chronic Liver Diseases Associated With Hepatic Steatosis
ClinicalTrials.gov study NCT05335603. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.