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ShareScore release 0.9.0
Dataset results
48 results for “high risk activity”
Health Education Materials With/Out a Physical Activity Program for Patients Who Have Undergone Treatment for High-Risk Stage II or Stage III Colon Cancer
ClinicalTrials.gov study NCT00819208. IPD Sharing: NO. Countries: 6. Publications: 5.
A Study of Subcutaneous Daratumumab Versus Active Monitoring in Participants With High-Risk Smoldering Multiple Myeloma
ClinicalTrials.gov study NCT03301220. IPD Sharing: Not stated. Countries: 24. Publications: 1.
Study to Evaluate Activity of 2 Dose Levels of Imetelstat in Participants With Intermediate-2 or High-Risk Myelofibrosis (MF) Previously Treated With Janus Kinase (JAK) Inhibitor
ClinicalTrials.gov study NCT02426086. IPD Sharing: Not stated. Countries: 11. Publications: 1.
A Study of Atezolizumab Plus Bevacizumab Versus Active Surveillance as Adjuvant Therapy in Patients With Hepatocellular Carcinoma at High Risk of Recurrence After Surgical Resection or Ablation
ClinicalTrials.gov study NCT04102098. IPD Sharing: YES. Countries: 26. Publications: 2.
Dataset for "Activation of the mPFC-NAc pathway reduces motor impulsivity but does not affect risk-related decision-making in innately high-impulsive male rats"
<p><span>Attention-deficit/hyperactivity disorder (ADHD) and substance use disorders</span><span> (SUD) are characterized by exacerbated motor and risk-related impulsivities, which are associated with decreased cortical activity. In rodents, the medial prefrontal cortex (mPFC) and nucleus accumbens (NAc) have been separately implicated in impulsive behaviors, but studies on the specific role of the mPFC-NAc pathway in these behaviors are limited. Here, we investigated whether heightened impulsive behaviors are associated with reduced mPFC activity in rodents, and determined the involvement of the mPFC-NAc pathway in motor and risk-related impulsivities. We used the Roman High- (RHA) and Low-Avoidance (RLA) rat lines, which display divergent phenotypes in impulsivity. To investigate alterations in cortical activity in relation to impulsivity, regional brain glucose metabolism was measured using positron emission tomography and [<sup>18</sup>F]-fluorodeoxyglucose ([<sup>18</sup>F]FDG). Using chemogenetics, the activity of the mPFC-NAc pathway was either selectively activated in high-impulsive RHA rats or inhibited in low-impulsive RLA rats, and the effects of these manipulations on motor and risk-related impulsivity were concurrently assessed using the rat gambling task. We showed that basal [<sup>18</sup>F]FDG uptake was lower in the mPFC and NAc of RHA compared to RLA rats. Activation of the mPFC-NAc pathway in RHA rats reduced motor impulsivity, without affecting risk-related decision-making. Conversely, inhibition of the mPFC-NAc pathway had no effect in RLA rats. Our results suggest that the mPFC-NAc pathway controls motor impulsivity, but has limited involvement in risk-related decision-making. Our findings suggest that reducing fronto-striatal activity may help attenuate motor impulsivity in patients with impulse control dysregulation like ADHD or SUD.</span></p>
Data from: Type 1 interferon-inducible gene expression in QuantiFERON Gold TB-positive uveitis: a tool to stratify a high versus low risk of active tuberculosis?
QuantiFERON-Gold TB (QFT)-positive patients with undetermined cause of uveitis are problematic in terms of whether to diagnose and treat them for tuberculosis (TB). Here, we investigated whether peripheral blood expression of type 1 interferon (IFN)-inducible genes may be of use to stratify QFT-positive patients with uveitis into groups of high versus low risk of having active TB-associated uveitis. We recruited all new uveitis patients in Cipto Mangunkusumo Hospital, Jakarta, Indonesia for one year. We included 12 patients with uveitis and clinically diagnosed active pulmonary TB, 58 QFT-positive patients with uveitis of unknown cause, 10 newly diagnosed sputum-positive active pulmonary TB patients without uveitis and 23 QFT-negative healthy controls. Expression of 35 type 1 IFN-inducible genes was measured in peripheral blood cells from active pulmonary TB patients without uveitis and healthy controls. Differentially expressed genes were identified and used for further clustering analyses of the uveitis groups. A type-1 IFN gene signature score was calculated and the optimal cut-off value for this score to differentiate active pulmonary TB from healthy controls was determined and applied to QFT-positive patients with uveitis of unknown cause. Ten type 1 IFN-inducible genes were differentially expressed between active pulmonary TB and healthy controls. Expression of these 10 genes in QFT-positive patients with uveitis of unknown cause revealed three groups: 1); patients resembling active pulmonary TB, 2); patients resembling healthy controls, and 3); patients displaying an in-between gene expression pattern. A type 1 IFN gene signature score ≥5.61 displayed high sensitivity (100%) and specificity (91%) for identification of active TB. Application of this score to QFT-positive patients with uveitis of unknown cause yielded two groups with expected different likelihood (high vs. low) of having active-TB uveitis, and therefore may be useful in clinical management decisions.
Patient Activation in High-Risk Patients With Heart Failure
ClinicalTrials.gov study NCT00260650. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Pacifier Activated Device and Mother's Voice in Infants at High-risk for Cerebral Palsy
ClinicalTrials.gov study NCT03230032. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Diet & Activity Community Trial: High-Risk Inflammation
ClinicalTrials.gov study NCT01760902. IPD Sharing: Not stated. Countries: 1. Publications: 1.
High Physical Activity During a Weight Loss Intervention for Breast Cancer Survivors and High Risk Women
ClinicalTrials.gov study NCT03270111. IPD Sharing: NO. Countries: 1. Publications: 1.
Analysis of Natural Killer Cell Activity (NKA) in Whole Blood in High Risk Subjects Undergoing Colonoscopy
ClinicalTrials.gov study NCT03249727. IPD Sharing: NO. Countries: 1. Publications: 1.
Energy Balance Interventions in Increasing Physical Activity in Breast Cancer Gene Positive Patients, Lynch Syndrome-Positive Patients, CLL Survivors or High-Risk Family Members
ClinicalTrials.gov study NCT02194387. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Active Detection of the Extension of Atherothrombosis in High Risk Coronary Patients
ClinicalTrials.gov study NCT00445835. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effect of Paint-by-Numbers Activity on Stress and Prenatal Attachment in High-Risk Pregnancies
ClinicalTrials.gov study NCT06955312. IPD Sharing: NO. Countries: 0. Publications: 1.
Targeted Active Case Detection Among High Risk Populations in Southern Lao Peoples Democratic Republic
ClinicalTrials.gov study NCT03783299. IPD Sharing: NO. Countries: 1. Publications: 8.
First-in-human Study Aiming to Characterize the Safety, Tolerability, Pharmacokinetic and Preliminary Signs of Activity of ABD-3001 in Refractory or Relapsed AML and High Risk MDS Adult Patients
ClinicalTrials.gov study NCT05601726. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: Type 1 interferon-inducible gene expression in QuantiFERON Gold TB-positive uveitis: a tool to stratify a high versus low risk of active tuberculosis?
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Evaluation of an Active Decision Support System for Hemodynamic Optimization During High Risk Vascular Surgery
ClinicalTrials.gov study NCT03012919. IPD Sharing: Not stated. Countries: 0. Publications: 4.
Safety, Clinical Activity, Pharmacokinetics (PK) and Pharmacodynamics Study of GSK2879552, Alone or With Azacitidine, in Subjects With High Risk Myelodysplastic Syndromes (MDS)
ClinicalTrials.gov study NCT02929498. IPD Sharing: Not stated. Countries: 2. Publications: 0.
A Study of Immediate 9 Months Adjuvant Hormone Therapy With Triptorelin 11.25 mg Versus Active Surveillance After Radical Prostatectomy in High Risk Prostate Cancer Patients.
ClinicalTrials.gov study NCT01753297. IPD Sharing: Not stated. Countries: 2. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.