Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
5
datasets available to search
ShareScore release 0.9.0
Dataset results
5 results for “high-risk stroke population”
Polymorphisms in genes related to inflammation and endothelial function in the high-risk stroke population
<p><span><strong>Aim</strong>:</span><span> T</span><span>o investigate </span><span>incidence of ischemic stroke and other vascular events during a 4.7-year follow-up </span><span>in the </span><span>high-risk stroke population</span><span>, and to identify </span><span>the associations of </span><span>the 19 single nucleotide polymorphisms (SNPs)</span> <span>in genes related to inflammation and endothelial function</span><span> and </span><span>interaction among these</span> <span>SNPs</span><span> with outcomes. </span><span> </span></p> <p><span><strong>Methods</strong>: </span><span>According to </span><span>the China National Stroke Screening Survey programme, we performed this multi-center </span><span>community</span><span>-based sectional survey and prospective cohort</span> <span>study in the Sichuan of southwestern China </span><span>from May 2015 to January 2020</span><span>. Eight communities were randomly selected in </span><span>Sichuan, </span><span>and the </span><span>residents in each community volunteered to participate in a face-to-face survey. </span><span>The 19 SNPs</span><span> in </span><span>genes related to </span><span>endothelial function and inflammation </span><span>were measured in </span><span>the high-risk stroke population</span><span>. </span><span>All subjects in high-risk stroke populations were followed-up for 4.7 years after the face-to-face survey. The primary outcome was a new ischemic stroke; the secondary outcome was a composite of new vascular events. </span></p> <p><span><strong>Results</strong>: </span><span>A total of</span><span> 2893 high-risk stroke population, </span><span>2698 (93.3%) completed a 4.7-year follow-up. Outcomes occurred in 192 (7.1%) subjects (</span><span>118 [4.4%] new </span><span>ischemic stroke</span><span>, 24 [0.9%] </span><span>hemorrhagic stroke, </span><span>53 [2.0%] </span><span>myocardial infarction</span><span>, and 33[1.2%]</span><span> death) in </span><span>the </span><span>2698</span><span> high-risk stroke population. </span><span>There were significant differences in </span><span>genotype distribution</span> <span>of</span><span> <em>TNF</em></span><span> rs3093662,</span><span> <em>IL6R</em> rs4845625 and <em>TLR4</em> rs752998</span> <span>between s</span><span>ubjects with and without outcomes</span><span> by </span><span>univariate analyses. </span><span>Generalized multifactor dimensionality reduction (GMDR) </span><span>analysis showed that </span><span>there was a significant gene-gene interaction among the </span><span>19 SNPs, the best model for outcomes was interaction among </span><em><span>IL6R</span></em><span> rs4845625, </span><span><em>TLR4</em> </span><span>rs1927911 and</span> <em><span>HABP2</span></em><span> rs932650</span> <span>(<em>P</em> = </span><span>0.004</span><span>).</span><span> The high-risk </span><span>interactive genotypes</span><span> among the 3 SNPs were independently associated with a higher risk for new ischemic stroke </span><span> (OR = 2.187, 95% CI: 1.256–5.374, <em>P</em></span><<span>0.001</span><span>) </span><span>and total vascular events </span><span>(OR = 2.382, 95% CI: 1.423–5.894, <em>P</em></span><<span>0.001</span><span>) </span><span>after adjustment with covariates. </span></p> <p><span><strong>Conclusion</strong>: </span><span>The </span><span>incidence of ischemic stroke and other vascular events was </span><span>found to be very high in the </span><span>high-risk stroke population. </span><span>There were associations of specific SNPs</span> <span>in genes related to inflammation and endothelial function</span><span> with outcomes. The high-risk </span><span>interactive genotypes among </span><em><span>IL6R</span></em><span> rs4845625, </span><span><em>TLR4</em> </span><span>rs1927911 and</span> <em><span>HABP2</span></em><span> rs932650 were in</span><span>dependently associated with a higher risk </span><span>for </span><span>new ischemic stroke and other vascular events.</span><span> These findings are expected to</span> <span>provide</span> <span>new strategies for prevention of </span><span>ischemic stroke and other vascular events.</span> </p>
Comprehensive Management of High-risk PopuLatIon of Stroke Based on Social Network
ClinicalTrials.gov study NCT05963828. IPD Sharing: NO. Countries: 1. Publications: 0.
Polymorphisms in genes related to inflammation and endothelial function in the high-risk stroke population
Open the record for dataset details and reuse information.
Screening and Management of High-risk Populations of Stroke in Dehui City
ClinicalTrials.gov study NCT05039034. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Wearable Devices Empowering Active Health Initiatives for High-Risk Stroke Populations
ClinicalTrials.gov study NCT06935513. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.